Adequacy of Endoscopic Ultrasound Core Needle Biopsy Specimen of Nonmalignant Hepatic Parenchymal Disease

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Clinical Gastroenterology and Hepatology

Volume 6, Issue 12, December 2008, Pages 1437-1440

Brief communication

Adequacy of Endoscopic Ultrasound Core Needle Biopsy Specimen of Nonmalignant

Hepatic Parenchymal Disease

References and further reading may be available for this article. To view

references and further reading you must purchase this article.

Ferga C. Gleeson, Amy C. Clayton‡, Lizhi Zhang‡, E. Clain, J.

Gores, Rajan, Tom C. Smyrk‡, Mark D. Topazian, K. Wang,

Maurits J. Wiersema and J. Levy, ,

‡Department of Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota

Fiterman Centre for Digestive Disease, Division of Gastroenterology and

Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota

Available online 26 July 2008.

Background & Aims

The adequacy and diagnostic yield of hepatic parenchymal disease Trucut biopsy

have not been determined. Therefore, our aim was to determine the adequacy of

endoscopic ultrasound (EUS)–guided Trucut liver biopsy for histopathologic

evaluation to include the number of complete portal tracts contained per

millimeter of acquired tissue.

Methods

A single institution retrospective review was made of 9 prospectively identified

patients who underwent a transgastric left liver lobe EUS-guided Trucut biopsy

during a 36-month period.

Results

Adequate diagnostic material, to include complete portal tract number evaluation

(median, 7) and connective tissue staining, was acquired to establish a

histopathologic diagnosis in all 9 cases. Sixty-three complete portal tracts

were established, resulting in 0.4 portal tracts per millimeter of tissue

acquired. Findings established by EUS Trucut left liver lobe biopsy included

mild steatosis (n = 4), cryptogenic cirrhosis (n = 2), chronic ductopenic

biliary tract disease (n = 1), portal fibrosis with ductular proliferation (n =

1), and alcoholic cirrhosis with hemosiderosis (n = 1).

Conclusions

EUS-guided Trucut left liver lobe biopsy yields suitable aggregate tissue for

diagnostic purposes to establish the presence of chronic liver disease.

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3cdf77586acc8771dbe3dabd784f0f9

Clinical Gastroenterology and Hepatology

Volume 6, Issue 12, December 2008, Pages 1437-1440

Brief communication

Adequacy of Endoscopic Ultrasound Core Needle Biopsy Specimen of Nonmalignant

Hepatic Parenchymal Disease

References and further reading may be available for this article. To view

references and further reading you must purchase this article.

Ferga C. Gleeson, Amy C. Clayton‡, Lizhi Zhang‡, E. Clain, J.

Gores, Rajan, Tom C. Smyrk‡, Mark D. Topazian, K. Wang,

Maurits J. Wiersema and J. Levy, ,

‡Department of Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota

Fiterman Centre for Digestive Disease, Division of Gastroenterology and

Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota

Available online 26 July 2008.

Background & Aims

The adequacy and diagnostic yield of hepatic parenchymal disease Trucut biopsy

have not been determined. Therefore, our aim was to determine the adequacy of

endoscopic ultrasound (EUS)–guided Trucut liver biopsy for histopathologic

evaluation to include the number of complete portal tracts contained per

millimeter of acquired tissue.

Methods

A single institution retrospective review was made of 9 prospectively identified

patients who underwent a transgastric left liver lobe EUS-guided Trucut biopsy

during a 36-month period.

Results

Adequate diagnostic material, to include complete portal tract number evaluation

(median, 7) and connective tissue staining, was acquired to establish a

histopathologic diagnosis in all 9 cases. Sixty-three complete portal tracts

were established, resulting in 0.4 portal tracts per millimeter of tissue

acquired. Findings established by EUS Trucut left liver lobe biopsy included

mild steatosis (n = 4), cryptogenic cirrhosis (n = 2), chronic ductopenic

biliary tract disease (n = 1), portal fibrosis with ductular proliferation (n =

1), and alcoholic cirrhosis with hemosiderosis (n = 1).

Conclusions

EUS-guided Trucut left liver lobe biopsy yields suitable aggregate tissue for

diagnostic purposes to establish the presence of chronic liver disease.

[Guest guest]

http://www.sciencedirect.com/science?_ob=ArticleURL & _udi=B7GGW-4T2S8SF-3 & _user=1\

0 & _coverDate=12%2F31%2F2008 & _rdoc=28 & _fmt=high & _orig=browse & _srch=doc-info(%23to\

c%2320161%232008%23999939987%23752137%23FLA%23display%23Volume) & _cdi=20161 & _sort\

=d & _docanchor= & _ct=36 & _acct=C000050221 & _version=1 & _urlVersion=0 & _userid=10 & md5=e\

3cdf77586acc8771dbe3dabd784f0f9

Clinical Gastroenterology and Hepatology

Volume 6, Issue 12, December 2008, Pages 1437-1440

Brief communication

Adequacy of Endoscopic Ultrasound Core Needle Biopsy Specimen of Nonmalignant

Hepatic Parenchymal Disease

References and further reading may be available for this article. To view

references and further reading you must purchase this article.

Ferga C. Gleeson, Amy C. Clayton‡, Lizhi Zhang‡, E. Clain, J.

Gores, Rajan, Tom C. Smyrk‡, Mark D. Topazian, K. Wang,

Maurits J. Wiersema and J. Levy, ,

‡Department of Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota

Fiterman Centre for Digestive Disease, Division of Gastroenterology and

Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota

Available online 26 July 2008.

Background & Aims

The adequacy and diagnostic yield of hepatic parenchymal disease Trucut biopsy

have not been determined. Therefore, our aim was to determine the adequacy of

endoscopic ultrasound (EUS)–guided Trucut liver biopsy for histopathologic

evaluation to include the number of complete portal tracts contained per

millimeter of acquired tissue.

Methods

A single institution retrospective review was made of 9 prospectively identified

patients who underwent a transgastric left liver lobe EUS-guided Trucut biopsy

during a 36-month period.

Results

Adequate diagnostic material, to include complete portal tract number evaluation

(median, 7) and connective tissue staining, was acquired to establish a

histopathologic diagnosis in all 9 cases. Sixty-three complete portal tracts

were established, resulting in 0.4 portal tracts per millimeter of tissue

acquired. Findings established by EUS Trucut left liver lobe biopsy included

mild steatosis (n = 4), cryptogenic cirrhosis (n = 2), chronic ductopenic

biliary tract disease (n = 1), portal fibrosis with ductular proliferation (n =

1), and alcoholic cirrhosis with hemosiderosis (n = 1).

Conclusions

EUS-guided Trucut left liver lobe biopsy yields suitable aggregate tissue for

diagnostic purposes to establish the presence of chronic liver disease.

[Guest guest]

http://www.sciencedirect.com/science?_ob=ArticleURL & _udi=B7GGW-4T2S8SF-3 & _user=1\

0 & _coverDate=12%2F31%2F2008 & _rdoc=28 & _fmt=high & _orig=browse & _srch=doc-info(%23to\

c%2320161%232008%23999939987%23752137%23FLA%23display%23Volume) & _cdi=20161 & _sort\

=d & _docanchor= & _ct=36 & _acct=C000050221 & _version=1 & _urlVersion=0 & _userid=10 & md5=e\

3cdf77586acc8771dbe3dabd784f0f9

Clinical Gastroenterology and Hepatology

Volume 6, Issue 12, December 2008, Pages 1437-1440

Brief communication

Adequacy of Endoscopic Ultrasound Core Needle Biopsy Specimen of Nonmalignant

Hepatic Parenchymal Disease

References and further reading may be available for this article. To view

references and further reading you must purchase this article.

Ferga C. Gleeson, Amy C. Clayton‡, Lizhi Zhang‡, E. Clain, J.

Gores, Rajan, Tom C. Smyrk‡, Mark D. Topazian, K. Wang,

Maurits J. Wiersema and J. Levy, ,

‡Department of Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota

Fiterman Centre for Digestive Disease, Division of Gastroenterology and

Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota

Available online 26 July 2008.

Background & Aims

The adequacy and diagnostic yield of hepatic parenchymal disease Trucut biopsy

have not been determined. Therefore, our aim was to determine the adequacy of

endoscopic ultrasound (EUS)–guided Trucut liver biopsy for histopathologic

evaluation to include the number of complete portal tracts contained per

millimeter of acquired tissue.

Methods

A single institution retrospective review was made of 9 prospectively identified

patients who underwent a transgastric left liver lobe EUS-guided Trucut biopsy

during a 36-month period.

Results

Adequate diagnostic material, to include complete portal tract number evaluation

(median, 7) and connective tissue staining, was acquired to establish a

histopathologic diagnosis in all 9 cases. Sixty-three complete portal tracts

were established, resulting in 0.4 portal tracts per millimeter of tissue

acquired. Findings established by EUS Trucut left liver lobe biopsy included

mild steatosis (n = 4), cryptogenic cirrhosis (n = 2), chronic ductopenic

biliary tract disease (n = 1), portal fibrosis with ductular proliferation (n =

1), and alcoholic cirrhosis with hemosiderosis (n = 1).

Conclusions

EUS-guided Trucut left liver lobe biopsy yields suitable aggregate tissue for

diagnostic purposes to establish the presence of chronic liver disease.