Association of Hepatitis B Virus Pre-S Deletions with the Development of Hepatocellular Carcinoma in Chronic Hepatitis B

[Guest guest]

J Infect Dis. 2011 Jan 12. [Epub ahead of print]

Association of Hepatitis B Virus Pre-S Deletions with the Development of

Hepatocellular Carcinoma in Chronic Hepatitis B.

Yeung P, Wong DK, Lai CL, Fung J, Seto WK, Yuen MF.

Department of Medicine, The University of Hong Kong, Queen Hospital, Hong

Kong.

Abstract

Background. We aimed to determine whether hepatitis B virus (HBV) pre-S deletion

was an independent factor for the development of hepatocellular carcinoma (HCC).

Methods. Pre-S deletions were determined in HBV isolates from 115 chronic

hepatitis B (CHB) patients with HCC. Sixty-nine patients were further matched

with 69 CHB patients without HCC for age, sex, hepatitis B e antigen (HBeAg)

status, and HBV genotype. Results. HBV pre-S deletions were clustered mainly in

the 3' end of pre-S1 and 5' end of pre-S2 regions. Adjusted for confounding risk

factors, patients with HCC had a higher prevalence of HBV with pre-S deletions

than did patients without HCC (23 [33.3%] of 69 vs 11 [15.9%] of 69; P = .018;

odds ratio [OR], 2.64). In particular, only pre-S2 deletions but not pre-S1

deletions were significantly associated with the development of HCC (P = .020).

A higher prevalence of pre-S deletions was observed in HBV isolates from HCC

patients under the age of 50 years than from those older than 50 years (10

[62.5%] of 16 vs 13 [24.5%] of 53; P = .012; OR, 5.13). Emergence of de novo

pre-S deletions was documented before the development of HCC. Conclusions. HBV

pre-S2 deletions were an independent factor associated with the development of

HCC. Its oncogenic role may be more important in young patients with HCC.

PMID: 21227916 [PubMed - as supplied by publisher

[Guest guest]

J Infect Dis. 2011 Jan 12. [Epub ahead of print]

Association of Hepatitis B Virus Pre-S Deletions with the Development of

Hepatocellular Carcinoma in Chronic Hepatitis B.

Yeung P, Wong DK, Lai CL, Fung J, Seto WK, Yuen MF.

Department of Medicine, The University of Hong Kong, Queen Hospital, Hong

Kong.

Abstract

Background. We aimed to determine whether hepatitis B virus (HBV) pre-S deletion

was an independent factor for the development of hepatocellular carcinoma (HCC).

Methods. Pre-S deletions were determined in HBV isolates from 115 chronic

hepatitis B (CHB) patients with HCC. Sixty-nine patients were further matched

with 69 CHB patients without HCC for age, sex, hepatitis B e antigen (HBeAg)

status, and HBV genotype. Results. HBV pre-S deletions were clustered mainly in

the 3' end of pre-S1 and 5' end of pre-S2 regions. Adjusted for confounding risk

factors, patients with HCC had a higher prevalence of HBV with pre-S deletions

than did patients without HCC (23 [33.3%] of 69 vs 11 [15.9%] of 69; P = .018;

odds ratio [OR], 2.64). In particular, only pre-S2 deletions but not pre-S1

deletions were significantly associated with the development of HCC (P = .020).

A higher prevalence of pre-S deletions was observed in HBV isolates from HCC

patients under the age of 50 years than from those older than 50 years (10

[62.5%] of 16 vs 13 [24.5%] of 53; P = .012; OR, 5.13). Emergence of de novo

pre-S deletions was documented before the development of HCC. Conclusions. HBV

pre-S2 deletions were an independent factor associated with the development of

HCC. Its oncogenic role may be more important in young patients with HCC.

PMID: 21227916 [PubMed - as supplied by publisher

[Guest guest]

J Infect Dis. 2011 Jan 12. [Epub ahead of print]

Association of Hepatitis B Virus Pre-S Deletions with the Development of

Hepatocellular Carcinoma in Chronic Hepatitis B.

Yeung P, Wong DK, Lai CL, Fung J, Seto WK, Yuen MF.

Department of Medicine, The University of Hong Kong, Queen Hospital, Hong

Kong.

Abstract

Background. We aimed to determine whether hepatitis B virus (HBV) pre-S deletion

was an independent factor for the development of hepatocellular carcinoma (HCC).

Methods. Pre-S deletions were determined in HBV isolates from 115 chronic

hepatitis B (CHB) patients with HCC. Sixty-nine patients were further matched

with 69 CHB patients without HCC for age, sex, hepatitis B e antigen (HBeAg)

status, and HBV genotype. Results. HBV pre-S deletions were clustered mainly in

the 3' end of pre-S1 and 5' end of pre-S2 regions. Adjusted for confounding risk

factors, patients with HCC had a higher prevalence of HBV with pre-S deletions

than did patients without HCC (23 [33.3%] of 69 vs 11 [15.9%] of 69; P = .018;

odds ratio [OR], 2.64). In particular, only pre-S2 deletions but not pre-S1

deletions were significantly associated with the development of HCC (P = .020).

A higher prevalence of pre-S deletions was observed in HBV isolates from HCC

patients under the age of 50 years than from those older than 50 years (10

[62.5%] of 16 vs 13 [24.5%] of 53; P = .012; OR, 5.13). Emergence of de novo

pre-S deletions was documented before the development of HCC. Conclusions. HBV

pre-S2 deletions were an independent factor associated with the development of

HCC. Its oncogenic role may be more important in young patients with HCC.

PMID: 21227916 [PubMed - as supplied by publisher

[Guest guest]

J Infect Dis. 2011 Jan 12. [Epub ahead of print]

Association of Hepatitis B Virus Pre-S Deletions with the Development of

Hepatocellular Carcinoma in Chronic Hepatitis B.

Yeung P, Wong DK, Lai CL, Fung J, Seto WK, Yuen MF.

Department of Medicine, The University of Hong Kong, Queen Hospital, Hong

Kong.

Abstract

Background. We aimed to determine whether hepatitis B virus (HBV) pre-S deletion

was an independent factor for the development of hepatocellular carcinoma (HCC).

Methods. Pre-S deletions were determined in HBV isolates from 115 chronic

hepatitis B (CHB) patients with HCC. Sixty-nine patients were further matched

with 69 CHB patients without HCC for age, sex, hepatitis B e antigen (HBeAg)

status, and HBV genotype. Results. HBV pre-S deletions were clustered mainly in

the 3' end of pre-S1 and 5' end of pre-S2 regions. Adjusted for confounding risk

factors, patients with HCC had a higher prevalence of HBV with pre-S deletions

than did patients without HCC (23 [33.3%] of 69 vs 11 [15.9%] of 69; P = .018;

odds ratio [OR], 2.64). In particular, only pre-S2 deletions but not pre-S1

deletions were significantly associated with the development of HCC (P = .020).

A higher prevalence of pre-S deletions was observed in HBV isolates from HCC

patients under the age of 50 years than from those older than 50 years (10

[62.5%] of 16 vs 13 [24.5%] of 53; P = .012; OR, 5.13). Emergence of de novo

pre-S deletions was documented before the development of HCC. Conclusions. HBV

pre-S2 deletions were an independent factor associated with the development of

HCC. Its oncogenic role may be more important in young patients with HCC.

PMID: 21227916 [PubMed - as supplied by publisher