Do young hepatocellular carcinoma patients have worse prognosis? The paradox of

[Guest guest]

Liver International

Volume 26 Page 766 - September 2006

doi:10.1111/j.1478-3231.2006.01309.x

Volume 26 Issue 7

Clinical Studies

Do young hepatocellular carcinoma patients have worse prognosis? The paradox

of age as a prognostic factor in the survival of hepatocellular carcinoma

patients

Chien-Hung Chen1, Ting-Tsung Chang2, Ken-Sheng Cheng3, Wei-Wen Su4,

Sheng-Shun Yang5, Hans Hsienhong Lin6, Shun-Sheng Wu4, Chuan-Mo Lee7,8,

Chi-Sin Changchien7,8, Chien-Jen Chen9, Jin-Chuan Sheu1, Ding-Shinn Chen1,10

and Sheng-Nan Lu7,8

Chen C-H, Chang T-T, Cheng K-S, Su W-W, Yang S-S, Lin HH, Wu S-S, Lee C-M,

Changchien C-S, Chen C-J, Sheu J-C, Chen D-S, Lu S-N. Do young

hepatocellular carcinoma patients have worse prognosis? The paradox of age

as prognostic factor on the survival of hepatocellular carcinoma patients.

Liver International 2006: 26: 766–773.

© 2006 The Authors. Journal compilation © 2006 Blackwell Munksgaard

Abstract: Background/Aims: Our previous study showed that male

hepatocellular carcinoma (HCC) patients below 40 years of age had the worst

survival in the initial several years, but had the best prognosis

thereafter. Thus, it seems that age has a paradoxical influence on the

prognosis. To further clarify the issue of age on HCC prognosis, we

initiated this study.

Methods: A total of 11 312 HCC cases from seven medical centers from 1986 to

2002 were included. We analyzed the 1-year survival and survival after 1

year.

Results: Male gender, age younger than 40 years old and hepatitis B virus

(HBV) were associated with worse 1-year survival. In contrast, male gender,

age younger than 40 years old and HBV were associated with better survival

after 1 year. Higher percentage of the young HCC patients had a tumor size

larger than 3 cm. 83.7% of HCC patients below 40 years of age were male and

89.8% of them were HBV carriers.

Conclusions: If we encountered a young HCC patient, the patient will

probably be a male HBV carrier. He would probably have larger tumor and is

more likely to expire within 1 year than the older HCC patients. However, if

the young HCC patient can survive for more than 1 year, he would probably

have better survival in the following years than the older patients.

_________________________________________________________________

On the road to retirement? Check out MSN Life Events for advice on how to

get there! http://lifeevents.msn.com/category.aspx?cid=Retirement

[Guest guest]

Liver International

Volume 26 Page 766 - September 2006

doi:10.1111/j.1478-3231.2006.01309.x

Volume 26 Issue 7

Clinical Studies

Do young hepatocellular carcinoma patients have worse prognosis? The paradox

of age as a prognostic factor in the survival of hepatocellular carcinoma

patients

Chien-Hung Chen1, Ting-Tsung Chang2, Ken-Sheng Cheng3, Wei-Wen Su4,

Sheng-Shun Yang5, Hans Hsienhong Lin6, Shun-Sheng Wu4, Chuan-Mo Lee7,8,

Chi-Sin Changchien7,8, Chien-Jen Chen9, Jin-Chuan Sheu1, Ding-Shinn Chen1,10

and Sheng-Nan Lu7,8

Chen C-H, Chang T-T, Cheng K-S, Su W-W, Yang S-S, Lin HH, Wu S-S, Lee C-M,

Changchien C-S, Chen C-J, Sheu J-C, Chen D-S, Lu S-N. Do young

hepatocellular carcinoma patients have worse prognosis? The paradox of age

as prognostic factor on the survival of hepatocellular carcinoma patients.

Liver International 2006: 26: 766–773.

© 2006 The Authors. Journal compilation © 2006 Blackwell Munksgaard

Abstract: Background/Aims: Our previous study showed that male

hepatocellular carcinoma (HCC) patients below 40 years of age had the worst

survival in the initial several years, but had the best prognosis

thereafter. Thus, it seems that age has a paradoxical influence on the

prognosis. To further clarify the issue of age on HCC prognosis, we

initiated this study.

Methods: A total of 11 312 HCC cases from seven medical centers from 1986 to

2002 were included. We analyzed the 1-year survival and survival after 1

year.

Results: Male gender, age younger than 40 years old and hepatitis B virus

(HBV) were associated with worse 1-year survival. In contrast, male gender,

age younger than 40 years old and HBV were associated with better survival

after 1 year. Higher percentage of the young HCC patients had a tumor size

larger than 3 cm. 83.7% of HCC patients below 40 years of age were male and

89.8% of them were HBV carriers.

Conclusions: If we encountered a young HCC patient, the patient will

probably be a male HBV carrier. He would probably have larger tumor and is

more likely to expire within 1 year than the older HCC patients. However, if

the young HCC patient can survive for more than 1 year, he would probably

have better survival in the following years than the older patients.

_________________________________________________________________

On the road to retirement? Check out MSN Life Events for advice on how to

get there! http://lifeevents.msn.com/category.aspx?cid=Retirement

[Guest guest]

Liver International

Volume 26 Page 766 - September 2006

doi:10.1111/j.1478-3231.2006.01309.x

Volume 26 Issue 7

Clinical Studies

Do young hepatocellular carcinoma patients have worse prognosis? The paradox

of age as a prognostic factor in the survival of hepatocellular carcinoma

patients

Chien-Hung Chen1, Ting-Tsung Chang2, Ken-Sheng Cheng3, Wei-Wen Su4,

Sheng-Shun Yang5, Hans Hsienhong Lin6, Shun-Sheng Wu4, Chuan-Mo Lee7,8,

Chi-Sin Changchien7,8, Chien-Jen Chen9, Jin-Chuan Sheu1, Ding-Shinn Chen1,10

and Sheng-Nan Lu7,8

Chen C-H, Chang T-T, Cheng K-S, Su W-W, Yang S-S, Lin HH, Wu S-S, Lee C-M,

Changchien C-S, Chen C-J, Sheu J-C, Chen D-S, Lu S-N. Do young

hepatocellular carcinoma patients have worse prognosis? The paradox of age

as prognostic factor on the survival of hepatocellular carcinoma patients.

Liver International 2006: 26: 766–773.

© 2006 The Authors. Journal compilation © 2006 Blackwell Munksgaard

Abstract: Background/Aims: Our previous study showed that male

hepatocellular carcinoma (HCC) patients below 40 years of age had the worst

survival in the initial several years, but had the best prognosis

thereafter. Thus, it seems that age has a paradoxical influence on the

prognosis. To further clarify the issue of age on HCC prognosis, we

initiated this study.

Methods: A total of 11 312 HCC cases from seven medical centers from 1986 to

2002 were included. We analyzed the 1-year survival and survival after 1

year.

Results: Male gender, age younger than 40 years old and hepatitis B virus

(HBV) were associated with worse 1-year survival. In contrast, male gender,

age younger than 40 years old and HBV were associated with better survival

after 1 year. Higher percentage of the young HCC patients had a tumor size

larger than 3 cm. 83.7% of HCC patients below 40 years of age were male and

89.8% of them were HBV carriers.

Conclusions: If we encountered a young HCC patient, the patient will

probably be a male HBV carrier. He would probably have larger tumor and is

more likely to expire within 1 year than the older HCC patients. However, if

the young HCC patient can survive for more than 1 year, he would probably

have better survival in the following years than the older patients.

_________________________________________________________________

On the road to retirement? Check out MSN Life Events for advice on how to

get there! http://lifeevents.msn.com/category.aspx?cid=Retirement

[Guest guest]

Liver International

Volume 26 Page 766 - September 2006

doi:10.1111/j.1478-3231.2006.01309.x

Volume 26 Issue 7

Clinical Studies

Do young hepatocellular carcinoma patients have worse prognosis? The paradox

of age as a prognostic factor in the survival of hepatocellular carcinoma

patients

Chien-Hung Chen1, Ting-Tsung Chang2, Ken-Sheng Cheng3, Wei-Wen Su4,

Sheng-Shun Yang5, Hans Hsienhong Lin6, Shun-Sheng Wu4, Chuan-Mo Lee7,8,

Chi-Sin Changchien7,8, Chien-Jen Chen9, Jin-Chuan Sheu1, Ding-Shinn Chen1,10

and Sheng-Nan Lu7,8

Chen C-H, Chang T-T, Cheng K-S, Su W-W, Yang S-S, Lin HH, Wu S-S, Lee C-M,

Changchien C-S, Chen C-J, Sheu J-C, Chen D-S, Lu S-N. Do young

hepatocellular carcinoma patients have worse prognosis? The paradox of age

as prognostic factor on the survival of hepatocellular carcinoma patients.

Liver International 2006: 26: 766–773.

© 2006 The Authors. Journal compilation © 2006 Blackwell Munksgaard

Abstract: Background/Aims: Our previous study showed that male

hepatocellular carcinoma (HCC) patients below 40 years of age had the worst

survival in the initial several years, but had the best prognosis

thereafter. Thus, it seems that age has a paradoxical influence on the

prognosis. To further clarify the issue of age on HCC prognosis, we

initiated this study.

Methods: A total of 11 312 HCC cases from seven medical centers from 1986 to

2002 were included. We analyzed the 1-year survival and survival after 1

year.

Results: Male gender, age younger than 40 years old and hepatitis B virus

(HBV) were associated with worse 1-year survival. In contrast, male gender,

age younger than 40 years old and HBV were associated with better survival

after 1 year. Higher percentage of the young HCC patients had a tumor size

larger than 3 cm. 83.7% of HCC patients below 40 years of age were male and

89.8% of them were HBV carriers.

Conclusions: If we encountered a young HCC patient, the patient will

probably be a male HBV carrier. He would probably have larger tumor and is

more likely to expire within 1 year than the older HCC patients. However, if

the young HCC patient can survive for more than 1 year, he would probably

have better survival in the following years than the older patients.

_________________________________________________________________

On the road to retirement? Check out MSN Life Events for advice on how to

get there! http://lifeevents.msn.com/category.aspx?cid=Retirement