Response to hepatitis B vaccine differs by birthweight among neonates.

[Guest guest]

Vaccine. 2011 Mar 5. [Epub ahead of print]

Response to hepatitis B vaccine differs by birthweight among neonates.

Cekmez F, Canpolat FE, Erdinç K, Cetinkaya M, Akýn O, Pamuk U, Sarýcý SU.

Neonatology Unit, Department of Pediatrics, School of Medicine, Gülhane Military

Academy of Medicine, Ankara, Turkey.

Abstract

OBJECTIVES: To assess the immunogenicity of same needle length of hepatitis B

vaccine for infants with different birthweights. Previous studies have focused

on obese adolescents and adults that have lower titers of antibody response to

hepatitis B vaccine. The aim of this study was to compare antibody titers of

macrosomic and other neonates for hepatitis B antibody with the same needle

length.

METHODS: 96 healthy infants were vaccinated at birth, 1, and 6 months of age

with hepatitis B vaccine, with follow-up to 7 months of age. Cord blood and

seventh month hepatitis B antibody titer were repeated. Infants were divided

into three groups, according to their birthweight, as macrosomic, appropriate

for gestational age and small for gestational age. The same needle with 26G and

16mm length was used for all infants.

RESULTS: Macrosomic infants with a birthweight over 4000g had lower antibody

levels than small and appropriate for gestational age infants.

CONCLUSIONS: These data support the hypothesis that birthweight has an effect on

response to HBV vaccine. Using the same needle length for immunization of

macrosomic infants for hepatitis B reveals significantly reduced antibody

titers, this can be related also to possible endogenous factors. Further studies

are needed to assess appropriate needle length and effects of other factors on

vaccine reactogenicity for macrosomic infants.Copyright © 2011. Published by

Elsevier Ltd.

PMID: 21385636 [PubMed - as supplied by publisher]

[Guest guest]

Vaccine. 2011 Mar 5. [Epub ahead of print]

Response to hepatitis B vaccine differs by birthweight among neonates.

Cekmez F, Canpolat FE, Erdinç K, Cetinkaya M, Akýn O, Pamuk U, Sarýcý SU.

Neonatology Unit, Department of Pediatrics, School of Medicine, Gülhane Military

Academy of Medicine, Ankara, Turkey.

Abstract

OBJECTIVES: To assess the immunogenicity of same needle length of hepatitis B

vaccine for infants with different birthweights. Previous studies have focused

on obese adolescents and adults that have lower titers of antibody response to

hepatitis B vaccine. The aim of this study was to compare antibody titers of

macrosomic and other neonates for hepatitis B antibody with the same needle

length.

METHODS: 96 healthy infants were vaccinated at birth, 1, and 6 months of age

with hepatitis B vaccine, with follow-up to 7 months of age. Cord blood and

seventh month hepatitis B antibody titer were repeated. Infants were divided

into three groups, according to their birthweight, as macrosomic, appropriate

for gestational age and small for gestational age. The same needle with 26G and

16mm length was used for all infants.

RESULTS: Macrosomic infants with a birthweight over 4000g had lower antibody

levels than small and appropriate for gestational age infants.

CONCLUSIONS: These data support the hypothesis that birthweight has an effect on

response to HBV vaccine. Using the same needle length for immunization of

macrosomic infants for hepatitis B reveals significantly reduced antibody

titers, this can be related also to possible endogenous factors. Further studies

are needed to assess appropriate needle length and effects of other factors on

vaccine reactogenicity for macrosomic infants.Copyright © 2011. Published by

Elsevier Ltd.

PMID: 21385636 [PubMed - as supplied by publisher]

[Guest guest]

Vaccine. 2011 Mar 5. [Epub ahead of print]

Response to hepatitis B vaccine differs by birthweight among neonates.

Cekmez F, Canpolat FE, Erdinç K, Cetinkaya M, Akýn O, Pamuk U, Sarýcý SU.

Neonatology Unit, Department of Pediatrics, School of Medicine, Gülhane Military

Academy of Medicine, Ankara, Turkey.

Abstract

OBJECTIVES: To assess the immunogenicity of same needle length of hepatitis B

vaccine for infants with different birthweights. Previous studies have focused

on obese adolescents and adults that have lower titers of antibody response to

hepatitis B vaccine. The aim of this study was to compare antibody titers of

macrosomic and other neonates for hepatitis B antibody with the same needle

length.

METHODS: 96 healthy infants were vaccinated at birth, 1, and 6 months of age

with hepatitis B vaccine, with follow-up to 7 months of age. Cord blood and

seventh month hepatitis B antibody titer were repeated. Infants were divided

into three groups, according to their birthweight, as macrosomic, appropriate

for gestational age and small for gestational age. The same needle with 26G and

16mm length was used for all infants.

RESULTS: Macrosomic infants with a birthweight over 4000g had lower antibody

levels than small and appropriate for gestational age infants.

CONCLUSIONS: These data support the hypothesis that birthweight has an effect on

response to HBV vaccine. Using the same needle length for immunization of

macrosomic infants for hepatitis B reveals significantly reduced antibody

titers, this can be related also to possible endogenous factors. Further studies

are needed to assess appropriate needle length and effects of other factors on

vaccine reactogenicity for macrosomic infants.Copyright © 2011. Published by

Elsevier Ltd.

PMID: 21385636 [PubMed - as supplied by publisher]

[Guest guest]

Vaccine. 2011 Mar 5. [Epub ahead of print]

Response to hepatitis B vaccine differs by birthweight among neonates.

Cekmez F, Canpolat FE, Erdinç K, Cetinkaya M, Akýn O, Pamuk U, Sarýcý SU.

Neonatology Unit, Department of Pediatrics, School of Medicine, Gülhane Military

Academy of Medicine, Ankara, Turkey.

Abstract

OBJECTIVES: To assess the immunogenicity of same needle length of hepatitis B

vaccine for infants with different birthweights. Previous studies have focused

on obese adolescents and adults that have lower titers of antibody response to

hepatitis B vaccine. The aim of this study was to compare antibody titers of

macrosomic and other neonates for hepatitis B antibody with the same needle

length.

METHODS: 96 healthy infants were vaccinated at birth, 1, and 6 months of age

with hepatitis B vaccine, with follow-up to 7 months of age. Cord blood and

seventh month hepatitis B antibody titer were repeated. Infants were divided

into three groups, according to their birthweight, as macrosomic, appropriate

for gestational age and small for gestational age. The same needle with 26G and

16mm length was used for all infants.

RESULTS: Macrosomic infants with a birthweight over 4000g had lower antibody

levels than small and appropriate for gestational age infants.

CONCLUSIONS: These data support the hypothesis that birthweight has an effect on

response to HBV vaccine. Using the same needle length for immunization of

macrosomic infants for hepatitis B reveals significantly reduced antibody

titers, this can be related also to possible endogenous factors. Further studies

are needed to assess appropriate needle length and effects of other factors on

vaccine reactogenicity for macrosomic infants.Copyright © 2011. Published by

Elsevier Ltd.

PMID: 21385636 [PubMed - as supplied by publisher]