The liver-cytokine-brain circuit in interferon-based treatment of patients with chronic viral hepatitis

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Journal of Viral Hepatitis, Volume 18, Number 8

The liver-cytokine-brain circuit in interferon-based treatment of patients with

chronic viral hepatitis

Authors: Stasi, C.; Zignego, A. L.; Laffi, G.; Rosselli, M.

Source: Journal of Viral Hepatitis, Volume 18, Number 8, 1 August 2011 , pp.

525-532(8)

Publisher: Wiley-Blackwell

Abstract:

Summary.  Psychiatric symptoms are commonly identified in patients with viral

hepatitis. They may have been present prior to the onset of disease and may

include symptoms related to addiction issues. Furthermore, the virus and

antiviral therapy, in particular interferon, may induce or modify psychiatric

symptoms. Recent data support chronic hepatitis C replication in the brain and

subsequent changes of cerebral metabolite spectra and magnetic resonance

alterations. In chronic viral hepatitis and in other chronic inflammatory

diseases, an alteration of the neuro-endocrine-immune system response has been

observed. Catecholamines and glucocorticoids modulate this immune/inflammatory

reaction. Psychiatric assessment and monitoring before, during and after

antiviral therapy can identify patients whose psychiatric symptoms preclude

therapy, and those who may benefit from psychopharmacological therapy and

counselling, thereby improving therapeutic results. This review will discuss

current insights into the complex interplay between cytokines, liver and brain

in chronic viral hepatitis closely associated with psychiatric issues,

especially in the case of antiviral therapy, with the aim of indicating future

research and possible treatments.

Document Type: Review article

DOI: 10.1111/j.1365-2893.2010.01418.x

Affiliations:1: Department of Internal Medicine, University of Florence,

Florence, Italy

Publication date: 2011-08-01

[Guest guest]

http://www.ingentaconnect.com/content/bsc/jvh/2011/00000018/00000008/art00001#ex\

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Journal of Viral Hepatitis, Volume 18, Number 8

The liver-cytokine-brain circuit in interferon-based treatment of patients with

chronic viral hepatitis

Authors: Stasi, C.; Zignego, A. L.; Laffi, G.; Rosselli, M.

Source: Journal of Viral Hepatitis, Volume 18, Number 8, 1 August 2011 , pp.

525-532(8)

Publisher: Wiley-Blackwell

Abstract:

Summary.  Psychiatric symptoms are commonly identified in patients with viral

hepatitis. They may have been present prior to the onset of disease and may

include symptoms related to addiction issues. Furthermore, the virus and

antiviral therapy, in particular interferon, may induce or modify psychiatric

symptoms. Recent data support chronic hepatitis C replication in the brain and

subsequent changes of cerebral metabolite spectra and magnetic resonance

alterations. In chronic viral hepatitis and in other chronic inflammatory

diseases, an alteration of the neuro-endocrine-immune system response has been

observed. Catecholamines and glucocorticoids modulate this immune/inflammatory

reaction. Psychiatric assessment and monitoring before, during and after

antiviral therapy can identify patients whose psychiatric symptoms preclude

therapy, and those who may benefit from psychopharmacological therapy and

counselling, thereby improving therapeutic results. This review will discuss

current insights into the complex interplay between cytokines, liver and brain

in chronic viral hepatitis closely associated with psychiatric issues,

especially in the case of antiviral therapy, with the aim of indicating future

research and possible treatments.

Document Type: Review article

DOI: 10.1111/j.1365-2893.2010.01418.x

Affiliations:1: Department of Internal Medicine, University of Florence,

Florence, Italy

Publication date: 2011-08-01

[Guest guest]

http://www.ingentaconnect.com/content/bsc/jvh/2011/00000018/00000008/art00001#ex\

pand/collapse

Journal of Viral Hepatitis, Volume 18, Number 8

The liver-cytokine-brain circuit in interferon-based treatment of patients with

chronic viral hepatitis

Authors: Stasi, C.; Zignego, A. L.; Laffi, G.; Rosselli, M.

Source: Journal of Viral Hepatitis, Volume 18, Number 8, 1 August 2011 , pp.

525-532(8)

Publisher: Wiley-Blackwell

Abstract:

Summary.  Psychiatric symptoms are commonly identified in patients with viral

hepatitis. They may have been present prior to the onset of disease and may

include symptoms related to addiction issues. Furthermore, the virus and

antiviral therapy, in particular interferon, may induce or modify psychiatric

symptoms. Recent data support chronic hepatitis C replication in the brain and

subsequent changes of cerebral metabolite spectra and magnetic resonance

alterations. In chronic viral hepatitis and in other chronic inflammatory

diseases, an alteration of the neuro-endocrine-immune system response has been

observed. Catecholamines and glucocorticoids modulate this immune/inflammatory

reaction. Psychiatric assessment and monitoring before, during and after

antiviral therapy can identify patients whose psychiatric symptoms preclude

therapy, and those who may benefit from psychopharmacological therapy and

counselling, thereby improving therapeutic results. This review will discuss

current insights into the complex interplay between cytokines, liver and brain

in chronic viral hepatitis closely associated with psychiatric issues,

especially in the case of antiviral therapy, with the aim of indicating future

research and possible treatments.

Document Type: Review article

DOI: 10.1111/j.1365-2893.2010.01418.x

Affiliations:1: Department of Internal Medicine, University of Florence,

Florence, Italy

Publication date: 2011-08-01

[Guest guest]

http://www.ingentaconnect.com/content/bsc/jvh/2011/00000018/00000008/art00001#ex\

pand/collapse

Journal of Viral Hepatitis, Volume 18, Number 8

The liver-cytokine-brain circuit in interferon-based treatment of patients with

chronic viral hepatitis

Authors: Stasi, C.; Zignego, A. L.; Laffi, G.; Rosselli, M.

Source: Journal of Viral Hepatitis, Volume 18, Number 8, 1 August 2011 , pp.

525-532(8)

Publisher: Wiley-Blackwell

Abstract:

Summary.  Psychiatric symptoms are commonly identified in patients with viral

hepatitis. They may have been present prior to the onset of disease and may

include symptoms related to addiction issues. Furthermore, the virus and

antiviral therapy, in particular interferon, may induce or modify psychiatric

symptoms. Recent data support chronic hepatitis C replication in the brain and

subsequent changes of cerebral metabolite spectra and magnetic resonance

alterations. In chronic viral hepatitis and in other chronic inflammatory

diseases, an alteration of the neuro-endocrine-immune system response has been

observed. Catecholamines and glucocorticoids modulate this immune/inflammatory

reaction. Psychiatric assessment and monitoring before, during and after

antiviral therapy can identify patients whose psychiatric symptoms preclude

therapy, and those who may benefit from psychopharmacological therapy and

counselling, thereby improving therapeutic results. This review will discuss

current insights into the complex interplay between cytokines, liver and brain

in chronic viral hepatitis closely associated with psychiatric issues,

especially in the case of antiviral therapy, with the aim of indicating future

research and possible treatments.

Document Type: Review article

DOI: 10.1111/j.1365-2893.2010.01418.x

Affiliations:1: Department of Internal Medicine, University of Florence,

Florence, Italy

Publication date: 2011-08-01