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Serotonin-Enhancing Drugs Could Trigger Stroke

Combinations of drugs may constrict blood vessels in brain, says new research

Jan. 7, 2002 (HealthScoutNews) -- Combinations of certain drugs that enhance the body's serotonin levels, including antidepressants, migraine therapies and diet pills, can trigger a stroke by narrowing blood vessels in the brain, a new study says.

Boston researchers report that the combinations may lead to a rare condition known as Call-Fleming syndrome, which can cause sudden and excruciating headache, seizures and stroke.

The findings could lead to changes in how patients with sudden-onset, severe headaches are treated, say the researchers, because current therapies often involve drugs that enhance serotonin, a hormone that transmits signals between neurons and causes narrowing of blood vessels.

Many legal and illegal drugs -- including antidepressants, St. 's wort, migraine remedies, cold remedies and diet pills, along with ecstasy, cocaine and amphetamines -- affect serotonin levels, says the study's senior investigator, Dr. Walter Koroshetz, associate chief of neurology at Massachusetts General Hospital.

Koroshetz describes Call-Fleming syndrome as a rare syndrome in which the blood vessels in the brain go into spasm. It can cause stroke if the vessels get too narrow and block blood flow to an area of the brain.

In the latest study, whose findings appear in tomorrow's issue of the journal Neurology, the researchers describe three patients who developed Call-Fleming syndrome while taking combinations of serotonin-enhancing drugs.

The first patient, a 46-year-old woman with a history of migraine, depression and asthma, developed what doctors describe as a "thunderclap" headache coupled with nausea and blurred vision. Koroshetz says that such a headache comes on within the space of a second, and that patients describe it as the worst they've ever experienced.

The woman was taking two antidepressants, an antipsychotic drug, an anticonvulsant, an asthma inhaler and a common cold medication that she had started two days previously.

Her headache and visual loss worsened, although a battery of tests could find nothing wrong with her. On her sixth day in hospital, magnetic resonance imaging revealed a small stroke on the left side of her brain. Ten days later, her headache became even worse, and after imaging revealed more strokes caused by blood vessel constriction, her doctors diagnosed Call-Fleming syndrome. They stopped her cold medication and one of the antidepressants. Within a week, her symptoms improved and she went home.

The second patient, a 45-year-old woman with a similar medical history, went to the hospital complaining of the same kind of "explosive" headache and nausea. She had taken a common cold remedy about an hour before her symptoms started. Three weeks later, she suffered several strokes because of narrowed blood vessels.

The doctors also removed a tumor that they found in her lung. They then took her off an antidepressant, and within a few days her headache disappeared. Four months later, she started a different drug for severe depression. Her headache returned within two weeks, but disappeared when she stopped the drug.

In the final case, a 34-year-old man developed a severe headache, combined with nausea, exhaustion and sensitivity to light. He wasn't taking any medications and he said he he used no drugs, but his mother had a history of migraine and he had experienced mild headaches in the past. His tests were normal, and he received an injection of painkillers, antimigraine medication and a steroid.

Dear Glitter,

It is the combination of ssri drugs or drugs that increase the levels of seratonin; SSRI's do not.

Respectfully,

From: glitterari@... <glitterari@...>Subject: Re:Seratonin, dangerous or not? (Attn. Glitter etc.)SSRI medications Date: Saturday, July 19, 2008, 9:47 AM

said:

If a person were to take a ton of L-Tryptophan, which actually is converted into Seratonin, may cause a harmful effect because seratonin does constict the blood vesals to some degree, where as there is not a SSRI drug that can or will do this. These drugs only deplete the brain of needed seratonin.

Sorry, but you are not correct on this one. ALL SSRI drugs are vasoconstrictors, which is partly why they also list STROKE as a side effect.

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Serotonin-Enhancing Drugs Could Trigger Stroke

Combinations of drugs may constrict blood vessels in brain, says new research

Jan. 7, 2002 (HealthScoutNews) -- Combinations of certain drugs that enhance the body's serotonin levels, including antidepressants, migraine therapies and diet pills, can trigger a stroke by narrowing blood vessels in the brain, a new study says.

Boston researchers report that the combinations may lead to a rare condition known as Call-Fleming syndrome, which can cause sudden and excruciating headache, seizures and stroke.

The findings could lead to changes in how patients with sudden-onset, severe headaches are treated, say the researchers, because current therapies often involve drugs that enhance serotonin, a hormone that transmits signals between neurons and causes narrowing of blood vessels.

Many legal and illegal drugs -- including antidepressants, St. 's wort, migraine remedies, cold remedies and diet pills, along with ecstasy, cocaine and amphetamines -- affect serotonin levels, says the study's senior investigator, Dr. Walter Koroshetz, associate chief of neurology at Massachusetts General Hospital.

Koroshetz describes Call-Fleming syndrome as a rare syndrome in which the blood vessels in the brain go into spasm. It can cause stroke if the vessels get too narrow and block blood flow to an area of the brain.

In the latest study, whose findings appear in tomorrow's issue of the journal Neurology, the researchers describe three patients who developed Call-Fleming syndrome while taking combinations of serotonin-enhancing drugs.

The first patient, a 46-year-old woman with a history of migraine, depression and asthma, developed what doctors describe as a "thunderclap" headache coupled with nausea and blurred vision. Koroshetz says that such a headache comes on within the space of a second, and that patients describe it as the worst they've ever experienced.

The woman was taking two antidepressants, an antipsychotic drug, an anticonvulsant, an asthma inhaler and a common cold medication that she had started two days previously.

Her headache and visual loss worsened, although a battery of tests could find nothing wrong with her. On her sixth day in hospital, magnetic resonance imaging revealed a small stroke on the left side of her brain. Ten days later, her headache became even worse, and after imaging revealed more strokes caused by blood vessel constriction, her doctors diagnosed Call-Fleming syndrome. They stopped her cold medication and one of the antidepressants. Within a week, her symptoms improved and she went home.

The second patient, a 45-year-old woman with a similar medical history, went to the hospital complaining of the same kind of "explosive" headache and nausea. She had taken a common cold remedy about an hour before her symptoms started. Three weeks later, she suffered several strokes because of narrowed blood vessels.

The doctors also removed a tumor that they found in her lung. They then took her off an antidepressant, and within a few days her headache disappeared. Four months later, she started a different drug for severe depression. Her headache returned within two weeks, but disappeared when she stopped the drug.

In the final case, a 34-year-old man developed a severe headache, combined with nausea, exhaustion and sensitivity to light. He wasn't taking any medications and he said he he used no drugs, but his mother had a history of migraine and he had experienced mild headaches in the past. His tests were normal, and he received an injection of painkillers, antimigraine medication and a steroid.

Dear Glitter,

It is the combination of ssri drugs or drugs that increase the levels of seratonin; SSRI's do not.

Respectfully,

From: glitterari@... <glitterari@...>Subject: Re:Seratonin, dangerous or not? (Attn. Glitter etc.)SSRI medications Date: Saturday, July 19, 2008, 9:47 AM

said:

If a person were to take a ton of L-Tryptophan, which actually is converted into Seratonin, may cause a harmful effect because seratonin does constict the blood vesals to some degree, where as there is not a SSRI drug that can or will do this. These drugs only deplete the brain of needed seratonin.

Sorry, but you are not correct on this one. ALL SSRI drugs are vasoconstrictors, which is partly why they also list STROKE as a side effect.

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Serotonin-Enhancing Drugs Could Trigger Stroke

Combinations of drugs may constrict blood vessels in brain, says new research

Jan. 7, 2002 (HealthScoutNews) -- Combinations of certain drugs that enhance the body's serotonin levels, including antidepressants, migraine therapies and diet pills, can trigger a stroke by narrowing blood vessels in the brain, a new study says.

Boston researchers report that the combinations may lead to a rare condition known as Call-Fleming syndrome, which can cause sudden and excruciating headache, seizures and stroke.

The findings could lead to changes in how patients with sudden-onset, severe headaches are treated, say the researchers, because current therapies often involve drugs that enhance serotonin, a hormone that transmits signals between neurons and causes narrowing of blood vessels.

Many legal and illegal drugs -- including antidepressants, St. 's wort, migraine remedies, cold remedies and diet pills, along with ecstasy, cocaine and amphetamines -- affect serotonin levels, says the study's senior investigator, Dr. Walter Koroshetz, associate chief of neurology at Massachusetts General Hospital.

Koroshetz describes Call-Fleming syndrome as a rare syndrome in which the blood vessels in the brain go into spasm. It can cause stroke if the vessels get too narrow and block blood flow to an area of the brain.

In the latest study, whose findings appear in tomorrow's issue of the journal Neurology, the researchers describe three patients who developed Call-Fleming syndrome while taking combinations of serotonin-enhancing drugs.

The first patient, a 46-year-old woman with a history of migraine, depression and asthma, developed what doctors describe as a "thunderclap" headache coupled with nausea and blurred vision. Koroshetz says that such a headache comes on within the space of a second, and that patients describe it as the worst they've ever experienced.

The woman was taking two antidepressants, an antipsychotic drug, an anticonvulsant, an asthma inhaler and a common cold medication that she had started two days previously.

Her headache and visual loss worsened, although a battery of tests could find nothing wrong with her. On her sixth day in hospital, magnetic resonance imaging revealed a small stroke on the left side of her brain. Ten days later, her headache became even worse, and after imaging revealed more strokes caused by blood vessel constriction, her doctors diagnosed Call-Fleming syndrome. They stopped her cold medication and one of the antidepressants. Within a week, her symptoms improved and she went home.

The second patient, a 45-year-old woman with a similar medical history, went to the hospital complaining of the same kind of "explosive" headache and nausea. She had taken a common cold remedy about an hour before her symptoms started. Three weeks later, she suffered several strokes because of narrowed blood vessels.

The doctors also removed a tumor that they found in her lung. They then took her off an antidepressant, and within a few days her headache disappeared. Four months later, she started a different drug for severe depression. Her headache returned within two weeks, but disappeared when she stopped the drug.

In the final case, a 34-year-old man developed a severe headache, combined with nausea, exhaustion and sensitivity to light. He wasn't taking any medications and he said he he used no drugs, but his mother had a history of migraine and he had experienced mild headaches in the past. His tests were normal, and he received an injection of painkillers, antimigraine medication and a steroid.

Dear Glitter,

It is the combination of ssri drugs or drugs that increase the levels of seratonin; SSRI's do not.

Respectfully,

From: glitterari@... <glitterari@...>Subject: Re:Seratonin, dangerous or not? (Attn. Glitter etc.)SSRI medications Date: Saturday, July 19, 2008, 9:47 AM

said:

If a person were to take a ton of L-Tryptophan, which actually is converted into Seratonin, may cause a harmful effect because seratonin does constict the blood vesals to some degree, where as there is not a SSRI drug that can or will do this. These drugs only deplete the brain of needed seratonin.

Sorry, but you are not correct on this one. ALL SSRI drugs are vasoconstrictors, which is partly why they also list STROKE as a side effect.

Get fantasy football with free live scoring. Sign up for FanHouse Fantasy Football today.

Link to comment
Share on other sites

Guest guest

Serotonin-Enhancing Drugs Could Trigger Stroke

Combinations of drugs may constrict blood vessels in brain, says new research

Jan. 7, 2002 (HealthScoutNews) -- Combinations of certain drugs that enhance the body's serotonin levels, including antidepressants, migraine therapies and diet pills, can trigger a stroke by narrowing blood vessels in the brain, a new study says.

Boston researchers report that the combinations may lead to a rare condition known as Call-Fleming syndrome, which can cause sudden and excruciating headache, seizures and stroke.

The findings could lead to changes in how patients with sudden-onset, severe headaches are treated, say the researchers, because current therapies often involve drugs that enhance serotonin, a hormone that transmits signals between neurons and causes narrowing of blood vessels.

Many legal and illegal drugs -- including antidepressants, St. 's wort, migraine remedies, cold remedies and diet pills, along with ecstasy, cocaine and amphetamines -- affect serotonin levels, says the study's senior investigator, Dr. Walter Koroshetz, associate chief of neurology at Massachusetts General Hospital.

Koroshetz describes Call-Fleming syndrome as a rare syndrome in which the blood vessels in the brain go into spasm. It can cause stroke if the vessels get too narrow and block blood flow to an area of the brain.

In the latest study, whose findings appear in tomorrow's issue of the journal Neurology, the researchers describe three patients who developed Call-Fleming syndrome while taking combinations of serotonin-enhancing drugs.

The first patient, a 46-year-old woman with a history of migraine, depression and asthma, developed what doctors describe as a "thunderclap" headache coupled with nausea and blurred vision. Koroshetz says that such a headache comes on within the space of a second, and that patients describe it as the worst they've ever experienced.

The woman was taking two antidepressants, an antipsychotic drug, an anticonvulsant, an asthma inhaler and a common cold medication that she had started two days previously.

Her headache and visual loss worsened, although a battery of tests could find nothing wrong with her. On her sixth day in hospital, magnetic resonance imaging revealed a small stroke on the left side of her brain. Ten days later, her headache became even worse, and after imaging revealed more strokes caused by blood vessel constriction, her doctors diagnosed Call-Fleming syndrome. They stopped her cold medication and one of the antidepressants. Within a week, her symptoms improved and she went home.

The second patient, a 45-year-old woman with a similar medical history, went to the hospital complaining of the same kind of "explosive" headache and nausea. She had taken a common cold remedy about an hour before her symptoms started. Three weeks later, she suffered several strokes because of narrowed blood vessels.

The doctors also removed a tumor that they found in her lung. They then took her off an antidepressant, and within a few days her headache disappeared. Four months later, she started a different drug for severe depression. Her headache returned within two weeks, but disappeared when she stopped the drug.

In the final case, a 34-year-old man developed a severe headache, combined with nausea, exhaustion and sensitivity to light. He wasn't taking any medications and he said he he used no drugs, but his mother had a history of migraine and he had experienced mild headaches in the past. His tests were normal, and he received an injection of painkillers, antimigraine medication and a steroid.

Dear Glitter,

It is the combination of ssri drugs or drugs that increase the levels of seratonin; SSRI's do not.

Respectfully,

From: glitterari@... <glitterari@...>Subject: Re:Seratonin, dangerous or not? (Attn. Glitter etc.)SSRI medications Date: Saturday, July 19, 2008, 9:47 AM

said:

If a person were to take a ton of L-Tryptophan, which actually is converted into Seratonin, may cause a harmful effect because seratonin does constict the blood vesals to some degree, where as there is not a SSRI drug that can or will do this. These drugs only deplete the brain of needed seratonin.

Sorry, but you are not correct on this one. ALL SSRI drugs are vasoconstrictors, which is partly why they also list STROKE as a side effect.

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