Report Questions FDA's Conclusions on Suicide Risk

[Guest guest]

Some great quotes from this:

Report Questions FDA's Conclusions on Suicide Risk

http://pn.psychiatryonline.org/cgi/content/full/41/1/29?etoc

Highlights from the article:

The American College of Neuropsychopharmacology (ACNP) has determined that

" SSRIs and other new-generation antidepressant drugs, in aggregate, are

associated with a small increase in the risk of [adverse event] reports

(AEs) of suicidal thinking or suicide attempts in youth. "

Both citalopram (Celexa) and nefazodone (Serzone) have demonstrated

significant efficacy in one clinical trial of youth with depression, but

each drug was separately found to be no different from placebo in a second

clinical trial.

Paroxetine (Paxil) and sertraline (Zoloft) each demonstrated significant

efficacy compared with placebo in one trial; however, two other trials of

each drug found no difference between drug and placebo.

Venlafaxine (Effexor) and mirtazapine (Remeron) were no better than placebo

in two clinical trials each.

Still another large meta-analysis, which included more than 700 randomized

clinical trials involving 87,650 patients, found more suicide attempts in

the SSRI group compared with placebo,

This means 402 patients would have to be given antidepressant medications

before one experienced an AE (adverse event) involving suicidal thoughts or

behaviors.

[Guest guest]

Some great quotes from this:

Report Questions FDA's Conclusions on Suicide Risk

http://pn.psychiatryonline.org/cgi/content/full/41/1/29?etoc

Highlights from the article:

The American College of Neuropsychopharmacology (ACNP) has determined that

" SSRIs and other new-generation antidepressant drugs, in aggregate, are

associated with a small increase in the risk of [adverse event] reports

(AEs) of suicidal thinking or suicide attempts in youth. "

Both citalopram (Celexa) and nefazodone (Serzone) have demonstrated

significant efficacy in one clinical trial of youth with depression, but

each drug was separately found to be no different from placebo in a second

clinical trial.

Paroxetine (Paxil) and sertraline (Zoloft) each demonstrated significant

efficacy compared with placebo in one trial; however, two other trials of

each drug found no difference between drug and placebo.

Venlafaxine (Effexor) and mirtazapine (Remeron) were no better than placebo

in two clinical trials each.

Still another large meta-analysis, which included more than 700 randomized

clinical trials involving 87,650 patients, found more suicide attempts in

the SSRI group compared with placebo,

This means 402 patients would have to be given antidepressant medications

before one experienced an AE (adverse event) involving suicidal thoughts or

behaviors.

[Guest guest]

Some great quotes from this:

Report Questions FDA's Conclusions on Suicide Risk

http://pn.psychiatryonline.org/cgi/content/full/41/1/29?etoc

Highlights from the article:

The American College of Neuropsychopharmacology (ACNP) has determined that

" SSRIs and other new-generation antidepressant drugs, in aggregate, are

associated with a small increase in the risk of [adverse event] reports

(AEs) of suicidal thinking or suicide attempts in youth. "

Both citalopram (Celexa) and nefazodone (Serzone) have demonstrated

significant efficacy in one clinical trial of youth with depression, but

each drug was separately found to be no different from placebo in a second

clinical trial.

Paroxetine (Paxil) and sertraline (Zoloft) each demonstrated significant

efficacy compared with placebo in one trial; however, two other trials of

each drug found no difference between drug and placebo.

Venlafaxine (Effexor) and mirtazapine (Remeron) were no better than placebo

in two clinical trials each.

Still another large meta-analysis, which included more than 700 randomized

clinical trials involving 87,650 patients, found more suicide attempts in

the SSRI group compared with placebo,

This means 402 patients would have to be given antidepressant medications

before one experienced an AE (adverse event) involving suicidal thoughts or

behaviors.

[Guest guest]

Some great quotes from this:

Report Questions FDA's Conclusions on Suicide Risk

http://pn.psychiatryonline.org/cgi/content/full/41/1/29?etoc

Highlights from the article:

The American College of Neuropsychopharmacology (ACNP) has determined that

" SSRIs and other new-generation antidepressant drugs, in aggregate, are

associated with a small increase in the risk of [adverse event] reports

(AEs) of suicidal thinking or suicide attempts in youth. "

Both citalopram (Celexa) and nefazodone (Serzone) have demonstrated

significant efficacy in one clinical trial of youth with depression, but

each drug was separately found to be no different from placebo in a second

clinical trial.

Paroxetine (Paxil) and sertraline (Zoloft) each demonstrated significant

efficacy compared with placebo in one trial; however, two other trials of

each drug found no difference between drug and placebo.

Venlafaxine (Effexor) and mirtazapine (Remeron) were no better than placebo

in two clinical trials each.

Still another large meta-analysis, which included more than 700 randomized

clinical trials involving 87,650 patients, found more suicide attempts in

the SSRI group compared with placebo,

This means 402 patients would have to be given antidepressant medications

before one experienced an AE (adverse event) involving suicidal thoughts or

behaviors.