Tricyclic Antidepressants May Increase the Incidence of Non-Hodgkin Lymphoma

[Guest guest]

Tricyclic Antidepressants May Increase the Incidence of Non-Hodgkin Lymphoma

http://professional.cancerconsultants.com/oncology_main_news.aspx?id=42253

Researchers from Denmark reported that patients who are long-term takers of tricyclic antidepressant medications have a 53% increased incidence of non-Hodgkin lymphoma (NHL).1 These data were also published in the July issue of Epidemiology.2

The incidence of NHL has been increasing over the past several decades. The reasons for this increase are unknown. In fact, the causes of most lymphomas are unknown, except for the relatively few that are associated with specific bacteria (Helicobacter pylori in gastric lymphoma) or with viruses, such as the Epstein-Barr virus (Burkitt's lymphoma) as well as HIV-related lymphomas, body cavity lymphomas (human herpes virus-8) or T-cell lymphoma (HTLV-1). However, none of these specific causes explain the increased incidence of lymphomas observed in recent years. There is speculation that exposure to chemicals, such as certain solvents, pesticides, herbicides, and water contaminated with nitrate, is responsible for the increased incidence of NHL. A recent report suggests that agricultural exposure to insecticides, herbicides, and fumigants was associated with an increased incidence of t(14;18)-positive but not t(14;18)-negative non-Hodgkin's lymphoma (NHL) (see related news). Another report suggests that occupational exposure to solvents, such as benzene, xylene, and toluene, may increase the risk of developing NHL and Hodgkin's lymphoma.

These researchers determined the incidence of NHL in 43,932 users of any antidepressant medication in North Jutland, Denmark, from 1989 through 2003. They reported that the use of tricyclic antidepressants was associated with an overall 53% increased incidence of NHL compared with nonuse. The risk was higher in users who had >10 prescriptions and more than five years of follow-up (IRR=2.50). The use of other types of antidepressants did not increase the risk of developing NHL.

Comments: These are very interesting results and if confirmed with other studies, would warrant investigation into the mechanism of this effect

[Guest guest]

Tricyclic Antidepressants May Increase the Incidence of Non-Hodgkin Lymphoma

http://professional.cancerconsultants.com/oncology_main_news.aspx?id=42253

Researchers from Denmark reported that patients who are long-term takers of tricyclic antidepressant medications have a 53% increased incidence of non-Hodgkin lymphoma (NHL).1 These data were also published in the July issue of Epidemiology.2

The incidence of NHL has been increasing over the past several decades. The reasons for this increase are unknown. In fact, the causes of most lymphomas are unknown, except for the relatively few that are associated with specific bacteria (Helicobacter pylori in gastric lymphoma) or with viruses, such as the Epstein-Barr virus (Burkitt's lymphoma) as well as HIV-related lymphomas, body cavity lymphomas (human herpes virus-8) or T-cell lymphoma (HTLV-1). However, none of these specific causes explain the increased incidence of lymphomas observed in recent years. There is speculation that exposure to chemicals, such as certain solvents, pesticides, herbicides, and water contaminated with nitrate, is responsible for the increased incidence of NHL. A recent report suggests that agricultural exposure to insecticides, herbicides, and fumigants was associated with an increased incidence of t(14;18)-positive but not t(14;18)-negative non-Hodgkin's lymphoma (NHL) (see related news). Another report suggests that occupational exposure to solvents, such as benzene, xylene, and toluene, may increase the risk of developing NHL and Hodgkin's lymphoma.

These researchers determined the incidence of NHL in 43,932 users of any antidepressant medication in North Jutland, Denmark, from 1989 through 2003. They reported that the use of tricyclic antidepressants was associated with an overall 53% increased incidence of NHL compared with nonuse. The risk was higher in users who had >10 prescriptions and more than five years of follow-up (IRR=2.50). The use of other types of antidepressants did not increase the risk of developing NHL.

Comments: These are very interesting results and if confirmed with other studies, would warrant investigation into the mechanism of this effect

[Guest guest]

Tricyclic Antidepressants May Increase the Incidence of Non-Hodgkin Lymphoma

http://professional.cancerconsultants.com/oncology_main_news.aspx?id=42253

Researchers from Denmark reported that patients who are long-term takers of tricyclic antidepressant medications have a 53% increased incidence of non-Hodgkin lymphoma (NHL).1 These data were also published in the July issue of Epidemiology.2

The incidence of NHL has been increasing over the past several decades. The reasons for this increase are unknown. In fact, the causes of most lymphomas are unknown, except for the relatively few that are associated with specific bacteria (Helicobacter pylori in gastric lymphoma) or with viruses, such as the Epstein-Barr virus (Burkitt's lymphoma) as well as HIV-related lymphomas, body cavity lymphomas (human herpes virus-8) or T-cell lymphoma (HTLV-1). However, none of these specific causes explain the increased incidence of lymphomas observed in recent years. There is speculation that exposure to chemicals, such as certain solvents, pesticides, herbicides, and water contaminated with nitrate, is responsible for the increased incidence of NHL. A recent report suggests that agricultural exposure to insecticides, herbicides, and fumigants was associated with an increased incidence of t(14;18)-positive but not t(14;18)-negative non-Hodgkin's lymphoma (NHL) (see related news). Another report suggests that occupational exposure to solvents, such as benzene, xylene, and toluene, may increase the risk of developing NHL and Hodgkin's lymphoma.

These researchers determined the incidence of NHL in 43,932 users of any antidepressant medication in North Jutland, Denmark, from 1989 through 2003. They reported that the use of tricyclic antidepressants was associated with an overall 53% increased incidence of NHL compared with nonuse. The risk was higher in users who had >10 prescriptions and more than five years of follow-up (IRR=2.50). The use of other types of antidepressants did not increase the risk of developing NHL.

Comments: These are very interesting results and if confirmed with other studies, would warrant investigation into the mechanism of this effect

[Guest guest]

Tricyclic Antidepressants May Increase the Incidence of Non-Hodgkin Lymphoma

http://professional.cancerconsultants.com/oncology_main_news.aspx?id=42253

Researchers from Denmark reported that patients who are long-term takers of tricyclic antidepressant medications have a 53% increased incidence of non-Hodgkin lymphoma (NHL).1 These data were also published in the July issue of Epidemiology.2

The incidence of NHL has been increasing over the past several decades. The reasons for this increase are unknown. In fact, the causes of most lymphomas are unknown, except for the relatively few that are associated with specific bacteria (Helicobacter pylori in gastric lymphoma) or with viruses, such as the Epstein-Barr virus (Burkitt's lymphoma) as well as HIV-related lymphomas, body cavity lymphomas (human herpes virus-8) or T-cell lymphoma (HTLV-1). However, none of these specific causes explain the increased incidence of lymphomas observed in recent years. There is speculation that exposure to chemicals, such as certain solvents, pesticides, herbicides, and water contaminated with nitrate, is responsible for the increased incidence of NHL. A recent report suggests that agricultural exposure to insecticides, herbicides, and fumigants was associated with an increased incidence of t(14;18)-positive but not t(14;18)-negative non-Hodgkin's lymphoma (NHL) (see related news). Another report suggests that occupational exposure to solvents, such as benzene, xylene, and toluene, may increase the risk of developing NHL and Hodgkin's lymphoma.

These researchers determined the incidence of NHL in 43,932 users of any antidepressant medication in North Jutland, Denmark, from 1989 through 2003. They reported that the use of tricyclic antidepressants was associated with an overall 53% increased incidence of NHL compared with nonuse. The risk was higher in users who had >10 prescriptions and more than five years of follow-up (IRR=2.50). The use of other types of antidepressants did not increase the risk of developing NHL.

Comments: These are very interesting results and if confirmed with other studies, would warrant investigation into the mechanism of this effect