Re: new study- potential treatment for CD

February 23, 2011

Thanks. Interesting research. As you say, it's probably quite a number of years before reaching Phase 3 human trials. Currently, the greatest hopes seem to be the drugs or enzymes being developed to ameliorate the effects of inadvertent gluttening: AT1001, ALV003, STAN1 enzyme, and CCX282-B. HogleFreelance academic librarianInstructor, online researchEmail: jjhogle@...Web: (under de- and re-construction) www.blueroom.comReality ain't what you think it isArt Graphics & Photographs[http://www.blueroom.com/realityaint.htm]From: alisonjhughes25 <alison.j.hughes@...>To:

Sent: Wed, February 23, 2011 9:09:55 AMSubject: [ ] new study- potential treatment for CD

has anyone seen this?

http://www.triumphdining.com/blog/gluten-free/2011/02/good-news-for-celiac-treatment-comes-in-a-small-package/?utm_source=Triumph+Dining+List & utm_campaign=060d3eeddd-Newsletter_Feb22_Stickers_Intro2_23_2011 & utm_medium=email

The results are of course preliminary (in a mouse model) and would need further research, and IF this could be an effective treatment we would still be about 10-15 years away from being able to have this, but it's still exciting that they are getting closer.

February 24, 2011

Thanks for the fascinating article. I posted on the blog and have copied it

here (I highly recommend people who are interested in this subject to read other

posts on the blog; a very good dialogue):

As an internist and new celiac, all of your concerns and hopes are valid. Yes,

inflammatory blockers are exciting, but they can have multiple side-effects, not

to mention prohibitive costs. Most of the research is in a treatment or a cure,

b/c that is where the money is-- it's sexy and innovative. Pharmaceuticals are

great when you *really * need them and it is the last resort; but oftentimes,

they can make our bodies even more imbalanced. What is so much more healthful

and sustainable, as many above have mentioned, is to allow our bodies to heal

themselves naturally with whole foods and lifestyle changes (I mean these on a

cultural level, not just having the individual deal with it in a blameworthy

fashion, which happens all too often).

Below is an article I find incredibly promising-- the idea behind it is that

these researchers in The Netherlands have compared our modern wheat varieties

with varieties from up to 100 years ago. They tested one of the specific gluten

epitopes known to trigger inflammatory T-cells in CD and found that it is much

higher in content in modern wheat varieties than in those pre-industrialization.

On top of that, they found much less genetic variation in gluten epitopes used

today, which again, can help explain why CD and gluten sensitivity is exploding

these days. They go on to suggest that not only could switching back to older

varieties likely prevent those w/ genetic susceptibility to CD from developing

the active disease, but that it could help reduce symptoms of current CD

patients.

This is exciting b/c this truly goes back to the etiology of why CD/gluten

problems are becoming more prevalent. This is the direction we ought to be

looking in, since a new pill or treatment can so often times lead to further

unforeseen problems. The problem with this approach, of course, is that it is

not a new sexy man-made solution that can be packaged and marketed. But does

anyone out there know of ways in which we can promote this kind of research?

Comments welcome!

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APCsVuk & sadssc=1

>

> Thanks. Interesting research. As you say, it's probably quite a number of

> years before reaching Phase 3 human trials.

>

> Currently, the greatest hopes seem to be the drugs or enzymes being developed

to

> ameliorate the effects of inadvertent gluttening: AT1001, ALV003, STAN1

enzyme,

> and CCX282-B.

>

> Hogle

> Freelance academic librarian

> Instructor, online research

> Email: jjhogle@...

> Web: (under de- and re-construction) www.blueroom.com

>

> Reality ain't what you think it is

> Art Graphics & Photographs

> [http://www.blueroom.com/realityaint.htm]

>

> ________________________________

> From: alisonjhughes25 <alison.j.hughes@...>

>

> Sent: Wed, February 23, 2011 9:09:55 AM

> Subject: [ ] new study- potential treatment for CD

>

> has anyone seen this?

>

http://www.triumphdining.com/blog/gluten-free/2011/02/good-news-for-celiac-treat\

ment-comes-in-a-small-package/?utm_source=Triumph+Dining+List & utm_campaign=060d3\

eeddd-Newsletter_Feb22_Stickers_Intro2_23_2011 & utm_medium=email

>

> The results are of course preliminary (in a mouse model) and would need

further

> research, and IF this could be an effective treatment we would still be about

> 10-15 years away from being able to have this, but it's still exciting that

they

> are getting closer.

>

February 26, 2011

Very interesting blog article -- especially the part about Accutane as a

possible trigger. It just so happens that I took Accutane in my teens (as well

as years of antibiotics) for acne. If I could roll back time...

, do let us know when you are well enough to practice again. I, for one,

would love to have a good doctor informed on the complexities of celiac.

Lynn

>

> Thanks for the fascinating article. I posted on the blog and have copied it

here (I highly recommend people who are interested in this subject to read other

posts on the blog; a very good dialogue):

>

> As an internist and new celiac, all of your concerns and hopes are valid. Yes,