Guest guest Posted February 16, 1999 Report Share Posted February 16, 1999 In a message dated 2/16/99 2:48:25 AM, vilik@... writes: << the Christy's insist on getting the urine quite alkaline before starting. Are you aware of this? >> Yes, this is implied in their book " Your Own Perfect Medicine. " It's good advice. However, getting started is more important than getting ready to get started. I look for signs and listen to myself on matters like this; I tend to be more accurate than not. All my signs were indicating that it was time to start. By the way, there is a new moon today in the sign of Aquarius, emphasizing friendships and the sharing of information. New moons are a good time to begin projects as they tend to culminate two weeks later at the full moon. The parts of the body ruled by Aquarius are the nervous system, the circulatory system, and the calves and ankles. I think this fast has something to do with my circulatory system; there's a problem in the blood that I'm seeking to heal. Armstrong didn't care too much about the pH factor in the urine when he recommend urine fasting. He was dealing with people who either drank their urine or died; when your choices are those, urine pH is secondary. " Insisting " on alkaline urine seems to me to be gilding the lily; one's urine is the very best medicine one can take, anytime. The body works it all out, anyway; I'm constantly amused by our arrogance that we can outthink our bodies because we have a small piece of the truth. <<One thought I've had about Armstrong. As you know he did a very long urine fast. He felt very healthy after, but he died a relatively young man (50's) the story being_that he was lifting weights and " his heart burst. " I have wondered if, in fact, his heart was weakened by the long fast. Long fasts tend to cause muscle lose, and the heart is a muscle.>> Many of Armstrong's patients were elderly and, with his help, lived on to a very ripe old age. He tells the story of an elderly man who fasted six months safely. To judge the therapy solely on the basis of Armstrong's outcome may be missing the point. It would be just as easy (and as inconclusive) to fault weight lifting for his early death; ergo, no one should lift weights because someone's heart burst while doing so. It could also have been that Armstrong's heart was weak from birth, strengthened by fasting, but not enough to withstand the exertion from weight training. This is all quite speculative and there's simply not enough hard information to draw reasonable conclusions from it. It may also be that it was Armstrong's time to go, programmed into his heart from the moment of his birth, regardless of how he spent his life, fasting or no. I've seen enough astrological charts with death indicators to know that, for most of us, the number of breaths we will take was decided before we arrived here, and it is hubris on our part to think our pathetic efforts can extend that (shorten, perhaps). What we do seem to have a say in is the quality of our lives while we are using up those breaths; we can do it in a state of health or from a sick bed. Besides, ultimately I don't listen to Armstrong or Christy, I listen to myself; I'll know when it is time to conclude the fast, and I don't foresee 45 days like Armstrong did. Although, if it took that long to rid my body of these pesky creatures who've invaded, I'd certainly do it. However, my hope is that by combining ozone with the fast, I can shorten the fasting period. Physiological results will tell me if I'm on track on this one. The address for the gallbladder list is: <gallstonesonelist>. I'll forward some related addresses to you as well. Glad to hear from you. With much affection, Jack Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 20, 1999 Report Share Posted February 20, 1999 Dear , What are your signs & symptoms? Regards, Noel. Noel 89 Royal Parade P O Box 137 Parkville VIC 3052 Australia Telephone 03 9347 8444 International 613 9347 8444 Fax 03 9347 8850 International 613 9347 850 Email noelc@... Sapere Aude: Dare to be wise. Urine Therapy From: Jules <jules@...> Hi, I'm , 31 in NYC & just joined this list. I have been very ill for many years, with many different confirmed & unconfirmed diagnosis - for the past month I have felt quite near death. Recently have a diagnosis of Candida Tropicalis and also likely Lyme disease, they do more Lyme disease tests on Monday, I only hope I am well enough to get to the Dr.s office! Does anyone here have helpful info on Lyme disease & / or it's treatment? Would urine therapy possibly help? I thought urine was waste that our body wants to get rid of! I also likely have some as yet unidentified parasites, they did a urine test and said I had a lot of proteins that are waste products of parasites, that indicate parasitic infection. Do I want to reingest that?? I am so glad for the internet, I am so ill and no one to help me, Dr.s here in NYC are very busy and hard to see. jules@ tuna.net -- @..@ (----) ( >==< ) Ribbit Note: emails to me are occasionally lost in transit. You may think that I have received a message that you've sent when, in fact, I have not. If you don't get a response, please try again. ------------------------------------------------------------------------ Suggestions on how we can improve ONElist? Go to the 'Suggestion' box on our new web site. ------------------------------------------------------------------------ OxyPLUS is an unmoderated e-ring dealing with oxidative therapies, and other alternative self- help subjects. THERE IS NO MEDICAL ADVICE HERE! This list is the 1st Amendment in action. The things you will find here are for information and research purposes only. We are people sharing information we believe in. If you act on ideas found here, you do so at your own risk. Self-help requires intelligence, common sense, and the ability to take responsibility for your own actions. By joining the list you agree to hold yourself FULLY responsible FOR yourself. Do not use any ideas found here without consulting a medical professional, unless you are a researcher or health care provider. You can subscribe/unsubscribe via e-mail by sending AN e-mail to the following address DO NOT PUT THIS IN THE SUBJECT LINE oxyplus-subscribeonelist - subscribe to a list. oxyplus-unsubscribeonelist - unsubscribe from a list. oxyplus-digestonelist - switch your subscription to digest mode. oxyplus-normalonelist - switch your subscription to normal mode. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 20, 1999 Report Share Posted February 20, 1999 In a message dated 2/19/99 11:18:19 PM, bobratliff@... writes: <<If urine is so pure why does it stink and kill plants? >> My urine doesn't stink. Yours probably does because of what you put into your body that must be processed out. You would find that if you drank only your urine all day, at the end of the day, it wouldn't stink, it would be pure. That was Armstrong's point. Remember that before urine leaves the body it has been filtered by the kidneys, an elaborate filtration system. Expensive kidney dialysis machines attempt to duplicate the function of the kidneys. It is commonly agreed that when urine leaves the body, it is sterile. As to why urine kills plants, I don't really know for sure, but I'm sure the answer is easily available. I would guess it's the uric acid or ammonia. Maybe one of our chemistry/biology friends on the list can answer this. I'm not sure it's entirely relevant, however. If you have sincere questions about urine therapy, you may wish to begin researching the subject. No one can do this for you. I began over three years ago and am only now discussing it publicly. Besides, the information you uncover on your own will have more value to you than anything I, or anyone else, could spoon-feed to you. For a starting point, I will repeat the URL that I gave in my earlier message about this: http://www.magna.com.au/~jglasgow/urine.htm I note that someone else on our e-ring has cited some other websites for urine therapy. You may wish to include them in your exploration of the subject. I am not selling urine therapy. I only wish to call attention to it for those who have eyes to see it. As Armstrong writes in his introduction " I have no secret remedy or patent medicine to sell. Indeed, although a layman, I am only following the policy required from all reputable members of the Medical Profession themselves, viz., to make not secret of any discovery which may prove useful in curing mankind: the more so as in many cases the treatment can be carried out at home without any financial outlay whatever. " Jack Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 20, 1999 Report Share Posted February 20, 1999 To , I've been dealing with candida and other related health issues for about a year. I've just learned about urine therapy through the oxy web ring. I'm on my fourth day and feeling and looking better and better. Far from being the disgusting waste product we've all been told it is, I am amazed to learn that urine is full of minerals, enzymes, hormones, and any where from 200 to 2000 different properties. Of the 100,000 cases of urine therapy that have been recorded in this century, there isn't a single case of a toxic reaction (the only possible exception might be if you have serious kidney problems) and the success rate for every imaginable condition appears to be phenomenal. This may truly be one of the great health secrets of the ages. Check out the following... Good Luck, Louis M http://www.all-natural.com/urine.html http://www.jesus-diet.com/ Jules wrote: > From: Jules <jules@...> > > Hi, > > I'm , 31 in NYC & just joined this list. I have been very ill > for many years, with many different confirmed & unconfirmed diagnosis > - for the past month I have felt quite near death. Recently have a > diagnosis of Candida Tropicalis and also likely Lyme disease, they do > more Lyme disease tests on Monday, I only hope I am well enough to get > to the Dr.s office! Does anyone here have helpful info on Lyme > disease & / or it's treatment? Would urine therapy possibly help? I > thought urine was waste that our body wants to get rid of! I also > likely have some as yet unidentified parasites, they did a urine test > and said I had a lot of proteins that are waste products of parasites, > that indicate parasitic infection. Do I want to reingest that?? I am > so glad for the internet, I am so ill and no one to help me, Dr.s here > in NYC are very busy and hard to see. > > > jules@ tuna.net > > -- > @..@ > (----) > ( >==< ) Ribbit > > Note: emails to me are occasionally lost in transit. You may think > that I have received a message that you've sent when, in fact, I have > not. If you don't get a response, please try again. > > ------------------------------------------------------------------------ > Suggestions on how we can improve ONElist? Go to the 'Suggestion' > box on our new web site. > ------------------------------------------------------------------------ > OxyPLUS is an unmoderated e-ring dealing with oxidative therapies, and other alternative self- help subjects. > > THERE IS NO MEDICAL ADVICE HERE! > > This list is the 1st Amendment in action. The things you will find here are for information and research purposes only. We are people sharing information we believe in. If you act on ideas found here, you do so at your own risk. Self-help requires intelligence, common sense, and the ability to take responsibility for your own actions. By joining the list you agree to hold yourself FULLY responsible FOR yourself. Do not use any ideas found here without consulting a medical professional, unless you are a researcher or health care provider. > > You can subscribe/unsubscribe via e-mail by sending AN e-mail to the following address > DO NOT PUT THIS IN THE SUBJECT LINE > oxyplus-subscribeonelist - subscribe to a list. > oxyplus-unsubscribeonelist - unsubscribe from a list. > oxyplus-digestonelist - switch your subscription to digest mode. > oxyplus-normalonelist - switch your subscription to normal mode. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 28, 1999 Report Share Posted July 28, 1999 In a message dated 7/28/99 6:32:34 PM Pacific Daylight Time, bobratliff@... writes: << his most recent statement by a western allopath seems to be additional authority for the opinion you have formed. Is this it? You are not taking a visible position on this. If you have done some serious research and are taking a position, please state it. Taking pot shots from behind someone else's learning or opinion, or resorting to ridicule, is not a mature way to approach this. >> Jack, Please tell us what is your position on this is and what research do you have to back this up? Would appreciate the info, thank you. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 28, 1999 Report Share Posted July 28, 1999 I'm not taking any position. Sorry to disappoint you. I am just sending some information contrair to what has been presented here. To use FYI, and for everyone's learning experience. My url was not from a western allopath, it was from a medical professor of an American university. Re read my original post. Just so this won't be a total waste. The university Prof. said urine contained waste produces from the body. All the url's I read from this group were from non professionals stating the urine was pure and clean. Best Regards, Ratliff SE Tenn. bobratliff@... So , I take it from your two previous posts (the other was a cite to the 10 worst medical URLs, #2 of which was a Urine Therapy site) that you are expressing your disapproval of the notion of urine therapy. This most recent statement by a western allopath seems to be additional authority for the opinion you have formed. Is this it? You are not taking a visible position on this. If you have done some serious research and are taking a position, please state it. Taking pot shots from behind someone else's learning or opinion, or resorting to ridicule, is not a mature way to approach this. If you have some facts to state, please state them; if you have formed an opinion, please tell us how you did that; if you have a question, please ask it. I look forward to what you have to say about this subject. Best regards, Jack --------------------------- Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 28, 1999 Report Share Posted July 28, 1999 , OK, but that still is misleading. Your liver has waste products. What blod passes to the kidney has already supposedly been cleaned by the liver. The kidney then figures out how much of each chemical in the urine get to stay there, custom dosing you. So, it would be more accurate to say that the urine has excesses of hormones, vitamins, etc. And, it is because it has excesses of these things that it can be beneficial. Further, IMO, if one doesn't investigate any therapy that has sprung up in unconnected cultures all over the globe for millennia, then one is a fool. Things do not become common in unconnected cultures for no reason. jim Ratliff wrote: > From: " Ratliff " <bobratliff@...> > > Those were my words. There words were urine contained > waste products. > > Best Regards, Ratliff > SE Tenn. > bobratliff@... > > Re: Re: Urine Therapy > > From: Jim Lambert <jlambert@...> > > > >From: " Ratliff " <bobratliff@...> > > > > >The biology faculty at Missouri Western State College > > > Urine may or may not be good for you to drink. But this indicates there > are > > >waste products there, not just purified water. > > , please notice they say, " Urine may or may not be good ... " which > means they have given an opinion based on opinion. I ignore anyting > including the word may, waiting instead for an informed opinion. > > jim > -- > jim@... http://www.entrance.to/madscience > http://www.entrance.to/poetry > > The biggest difference between genius & stupidity is that genius has its > limits. -- anony > > amicus certus in re incerta > > --------------------------- Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 28, 1999 Report Share Posted July 28, 1999 I'm not going to crack a whip as moderator, but it seems to me there is more ad hominem attack in this thread -- from different parties -- than is healthy for an intelligent discussion. Let's discuss issues, folks, and do our best to be polite in the process. This one appears to me to be escalating. the moderator SanteeNo1@... wrote: > From: SanteeNo1@... > > In a message dated 7/28/99 6:32:34 PM Pacific Daylight Time, > bobratliff@... writes: > > << his most recent statement > by a western allopath seems to be additional authority for the opinion you > have formed. Is this it? You are not taking a visible position on this. If > you have done some serious research and are taking a position, please state > it. Taking pot shots from behind someone else's learning or opinion, or > resorting to ridicule, is not a mature way to approach this. >> > > Jack, > > Please tell us what is your position on this is and what research do you have > to back this up? Would appreciate the info, thank you. > > > > --------------------------- Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 28, 1999 Report Share Posted July 28, 1999 Read this for an explanation. http://www.mwsc.edu/~rachow/Urinary.html Urinary System -The urinary system consists of the: -kidneys -ureters -urinary bladder -urethra Functions of the kidneys -The kidneys remove metabolic wastes from the blood and excrete them to the outside. -They also help regulate red blood cell production, blood pressure, calcium ion absorption, and the volume, composition, and pH of the blood. Best Regards, Ratliff SE Tenn. bobratliff@... Re: Re: Urine Therapy > > From: Jim Lambert <jlambert@...> > > > >From: " Ratliff " <bobratliff@...> > > > > >The biology faculty at Missouri Western State College > > > Urine may or may not be good for you to drink. But this indicates there > are > > >waste products there, not just purified water. > > , please notice they say, " Urine may or may not be good ... " which > means they have given an opinion based on opinion. I ignore anyting > including the word may, waiting instead for an informed opinion. > > jim > -- > jim@... http://www.entrance.to/madscience > http://www.entrance.to/poetry > > The biggest difference between genius & stupidity is that genius has its > limits. -- anony > > amicus certus in re incerta > > --------------------------- Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 28, 1999 Report Share Posted July 28, 1999 I was framed. That is not my quote. Re read my msgs. Best Regards, Ratliff SE Tenn. bobratliff@... Re: Re: Urine Therapy From: Jim Lambert <jlambert@...> I'm not going to crack a whip as moderator, but it seems to me there is more ad hominem attack in this thread -- from different parties -- than is healthy for an intelligent discussion. Let's discuss issues, folks, and do our best to be polite in the process. This one appears to me to be escalating. the moderator SanteeNo1@... wrote: > From: SanteeNo1@... > > In a message dated 7/28/99 6:32:34 PM Pacific Daylight Time, > bobratliff@... writes: > > << his most recent statement > by a western allopath seems to be additional authority for the opinion you > have formed. Is this it? You are not taking a visible position on this. If > you have done some serious research and are taking a position, please state > it. Taking pot shots from behind someone else's learning or opinion, or > resorting to ridicule, is not a mature way to approach this. >> > > Jack, > > Please tell us what is your position on this is and what research do you have > to back this up? Would appreciate the info, thank you. > > > > --------------------------- Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 29, 1999 Report Share Posted July 29, 1999 Dear , Thanks very much for posting that information on the kidneys. Dr. says that you can get 90% of the benefits of urine therapy by just peeing on your feet when in the shower. Beats drinking it ! Best of Health! Saul Pressman URL: http://www.plasmafire.com email: saul@... Join our mailing list and learn about ozone therapy at: /subscribe/ozonetherapy ---------------------------------------------------------------------------- ----- Re: Re: Urine Therapy >> >> From: Jim Lambert <jlambert@...> >> >> > >From: " Ratliff " <bobratliff@...> >> > >> > >The biology faculty at Missouri Western State College >> > > Urine may or may not be good for you to drink. But this indicates >there >> are >> > >waste products there, not just purified water. >> >> , please notice they say, " Urine may or may not be good ... " which >> means they have given an opinion based on opinion. I ignore anyting >> including the word may, waiting instead for an informed opinion. >> >> jim >> -- >> jim@... http://www.entrance.to/madscience >> http://www.entrance.to/poetry >> >> The biggest difference between genius & stupidity is that genius has its >> limits. -- anony >> >> amicus certus in re incerta >> >> --------------------------- Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 16, 2000 Report Share Posted June 16, 2000 Marie If you have a kidney or bladder infection there is a definite risk. The bacteria often present is E coli which can effect many areas of the body and cause serious problems, even death. Other kidney problems would alter the content of the urine, and would certainly effect urine therapy. If I had kidney problems and felt strongly about trying urine therapy (not saying I do, mind you) I would find a sympathetic medical doctor with training in the alternative therapies and discuss it fully before trying it Just my two cents Clea Urine therapy |Hi everyone! I also read that you cannot try urine therapy if |you have problems with your kidneys. | |Any comments? | |Bye for now, Marie | | |------------------------------------------------------------------------ |Remember four years of good friends, bad clothes, explosive chemistry |experiments. |1/5532/10/_/378/_/961124044/ |------------------------------------------------------------------------ | |Get HUGE info at http://www.cures for cancer.ws, and post your own links there. Unsubscribe by sending email to cures for cancer-unsubscribeegroups or by visiting http://www.bobhurt.com/subunsub.mv | | Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 28, 2000 Report Share Posted September 28, 2000 ---------------------------------------------------------------------------- ---- United States Patent 5,504,065 Hattori , et al. April 2, 1996 ---------------------------------------------------------------------------- ---- Agent for treating or preventing AIDS using human urine trypsin inhibitor Abstract Human urine trypsin inhibitor is provided as an agent for treating acquired immunodeficiency syndrome (AIDS), preventing the infection with AIDS or preventing the onset of AIDS after such infection. It can be administered intravenously for the treatment and externally for the prevention. ---------------------------------------------------------------------------- ---- Inventors: Hattori; Toshio (Kumamoto, JP); Takatsuki; Kiyoshi (Kumamoto, JP); Yuki; Yoshikazu (Kobe, JP) Assignee: JCR Pharmaceuticals Co., Ltd. (Hyogo, JP) Appl. No.: 261746 Filed: June 17, 1994 U.S. Class: 514/8; 530/395; 530/397; 530/834 Intern'l Class: A61K 038/14; A61K 038/57 Field of Search: 514/8 500/395,397,834 ---------------------------------------------------------------------------- ---- 4780209 Oct., 1988 Yuki et al. 210/635. Other References Proksch et al, J. Lab. Clin. Med. pp. 491-499 (1972). Primary Examiner: Schain; E. Attorney, Agent or Firm: Burgess, and Wayne ---------------------------------------------------------------------------- ---- Parent Case Text ---------------------------------------------------------------------------- ---- This application is a continuation of application Ser. No. 08/158,819, filed Nov. 26, 1993, now abandoned, which is a continuation of application Ser. No. 07/960,199, filed Oct. 9, 1992, now abandoned, which is a continuation of application Ser. No. 831,080, filed Feb. 5, 1992, now abandoned, which is a continuation of application Ser. No. 436,830, filed Nov. 15, 1989, now abandoned. ---------------------------------------------------------------------------- ---- Claims ---------------------------------------------------------------------------- ---- 1. A method for inhibiting syncytium formation in infection-free cells which come in contact with HIV-infected cells, said method comprising contacting said cells with unit doses of an inhibitory agent comprised of from 10 to 500 mg of human urine trypsin inhibitor. 2. A method for inhibiting the development of the AIDS virus as evidenced by an inhibition of syncytium formation in a subject which comprises administering to said subject unit doses containing 10 to 500 mg of an inhibitory agent comprised of human urine trypsin inhibitor. ---------------------------------------------------------------------------- ---- Description ---------------------------------------------------------------------------- ---- BACKGROUND OF THE INVENTION 1. Field of the Invention This invention relates to an agent for treating acquired immunodeficiency syndrome (AIDS), preventing AIDS virus infection and preventing the onset of AIDS after such infection. 2. Description of the Prior Art AIDS is now a focus of worldwide attention as a disease induced by human immunodeficiency virus (HIV, or AIDS virus) and characterized by bad prognosis. When infected with HIV, helper T cells, among others, are destroyed. Insufficiency of immunological competence thus results and this leads to such clinical features as serious opportunistic infection, carinii pneumonia, Kaposi sarcoma and AIDS-related encephalopathy. The disease is highly fatal. HIV infection-associated states or illnesses include a symptomatic carrier state, progressive or persistent generalized lymphoadenophathy (PGL), lymphoadenophathy syndrome (LAD), AIDS-related complex (ARC) and AIDS. No effective therapy for AIDS has been established as yet. The only agent known to be effective is 3'-azidothymidine that has been shown to have obvious life-prolonging effect in patients with AIDS who are suffering from carinii pneumonia. AZT is an HIV reverse transcriptase inhibitor and this effect brings about improvements in clinical symptoms and neurologic symptoms and temporary restoration of certain immune functions [H. Mitsuya et al.; Nature, 325, 773 (1987)]. Therefore, AZT is highly toxic to bone marrow and about 50% of patients treated with AZT require blood transfusion. No virucidal agent capable of specifically killing HIV without causing any serious adverse reactions in humans has not been discovered as yet. Reverse transcriptase inhibitors, such as AZT, cannot be considered to be potent therapeutic agents since they produce adverse effects and are effective only in the postponing of death. Accordingly, it is an object of the invention to provide an agent for treating AIDS and preventing HIV infection or the onset of AIDS after HIV infection. The present inventors made investigations into the interactions between AIDS virus and T cells or, in other words, the sites of infection. AIDS virus has an envelope glycoprotein (gp-120). Investigations have shown that gp-120 has a T cell receptor (CD-4)-binding site within the amino acid sequence from the 397th (from the N terminus of gp-120) to the 439th amino acid thereof [A. L. Lawrence et al.: Cell, 50, 975 (1987)]. According to more recent findings, the 24 amino acids (called epitope ..beta.) from the 308th (from the N terminus) to the 332th amino acid of gp-120 plays an important role in HIV infection [T. J. Palker: Proc. Natl. Acad. Sci. U.S.A., 85, 1932 (1988); S. Matsushita: J. Virol., 62 (6), 2107 (1988)]. That is to say, researchers, inclusive of the present inventors, have revealed that monoclonal antibodies to epitope .beta. of gp-120 can inhibit HIV infection. Accordingly, the present inventors searched for proteins having an amino acid sequence homologous to epitope .beta. using the National Biomedical Research Foundation data base. As a result, 90 proteins were listed, 11 of which were proteases or protease inhibitors. Among them, inter-.alpha.-trypsin inhibitors (ITIs), not only human ITI but also ITIs derived from various animals, showed that highest degree of homology to epitope .beta.. The arginine residue (Arg) in the homologous region was the protease activity inhibiting site of ITIs. While epitope .beta. is the variable region of gp-120, the amino acid sequence comprising several amino acids with Arg as the central figure was preserved in various HIV-1 strains. Therefore, the present inventors synthesized a peptide having 33 amino acids in its amino acid sequence, including the 54 amino acids of epitope .beta. and evaluated it for trypsin activity inhibition by it. As a result, it was found that said peptide could inhibit trypsin activity by 30% when BOC-Phe-Ser-Arg-MCA was used as a synthetic substrate. It was thus suggested that epitope .beta. might have protease inhibitor activity or be a very good substrate for protease. Human ITI is a glycoprotein occurring in human serum. It is a single-chain glycoprotein having an apparent molecular weight of about 180,000 as determined by SDS-PAGE (sodium dodecyl sulfate-polyacrylamide gel electrophoresis) and a carbohydrate content of about 8%. It is stable to acids and heat. On the other hand, human urine trypsin inhibitor (hereinafter referred to as " UTI " ) purified from human urine is a single-chain glycoprotein having an apparent molecular weight of about 45,000 as determined by SDS-PAGE. It is stable to heat and acids. Since both have the identical amino acid sequence on the N-terminal side, the ITI is presumably a precursor to UTI ( " Proteinase Inhibitors " , edited by A. J. Barrett et al., pages 389-398, Elsevier, 1986). UTI has two kunitz type domains closely resembling each other within its molecule. Nothing is known at all about what action, if any, said ITI and/or UTI can exert upon AIDS virus, however. In Japan, human UTI, also called urinastatin by generic name, is currently in wide clinical use as a drug for the treatment of acute pancreatitis and acute ventricular failure (hemorrhagic shock, septic shock, traumatic shock, burn shock). Since it is a glycoprotein derived from human urine, UTI is a very highly safe drug, scarcely presenting antigenicity, toxicity and other problems to humans. For these reasons, the present inventors performed an in vitro infection neutralization test to see whether UTI might be actually effective against HIV infection. The inhibition of HIV infection was assessed by the syncytium formation inhibition method, namely using, as an index, the syncytium formation inhibition in a mixed cell culture system containing LAV-1-infected CCRF-CEM cells and AIDS infection-free MOLT-4 clone 8 cells. In this way, UTI was found to inhibit, in a serum-free culture system, syncytium formation strongly at concentrations not lower than 300 .mu.M, moderately at a concentration of 100 .mu.M, and weakly at 30 .mu.M. Soybean trypsin inhibitor (SBTI) was also tested by the above method since epitope ..beta. shows homology, though weak, to the active site of SBTI. SBTI inhibited syncytium formation in a concentration-dependent manner at concentrations of 300 .mu.M to 3 mM, although its inhibitory activity was weaker than that of UTI. On the contrary, aprotinin, which is a bovine lung-derived trypsin inhibitor, did not inhibit syncytium formation. SBTI and aprotinin, which are heterologous proteins other than human-derived proteins, offer the antigenicity problem when they are repeatedly administered to humans. On the other hand, UTI can be considered to be an agent having very low toxicity. In fact, in acute toxicity testing in mice, rats and dogs, an intravenous dose of 150.times.10.sup.4 IU/kg body weight (i.e. about 600 mg/kg body weight) gave no deaths. In subacute toxicity testing, where a maximum daily dose of 60.times.10.sup.4 IU/kg body weight (i.e. about 240 mg/kg body weight) was intravenously administered to rats and a maximum daily dose of 30.times.10.sup.4 IU/kg body weight (i.e. about 120 mg/kg body weight) to dogs for consecutive 4 weeks, no serious adverse reactions were noted. SUMMARY OF THE INVENTION The present invention, that has been completed on the above findings, provides a therapeutic or prophylactic composition for the treatment of AIDS, the prevention of AIDS virus (HIV) infection or the prevention of the onset of AIDS after such infection which contains human urine trypsin inhibitor (UTI). BRIEF DESCRIPTION OF THE DRAWING FIG. 1 is a photographic representation of the conditions under which syncytium formation was inhibited in the test performed in Example 1. Picture a is for a negative control where HIV infection-free cells alone were cultured; picture b is for a positive control where infection-free cells and infected cells were mixedly cultured; pictures c and d are for the cases where infection-free cells and infected cells were mixedly cultured in the presence of human urinary trypsin inhibitor (UTI) at concentrations of 1 mM and 100 .mu.M, respectively. DETAILED DESCRIPTION OF THE INVENTION For treating AIDS or preventing the development of AIDS after HIV infection, UTI is preferably administered by the intravenous route, for example by intravenous injection or intravenous drip infusion. Injections for such purposes can be prepared by a per se known method. A preferred intravenous dose for each administration is within the range of 100 to 1,000 mg. For preventing HIV infection, the use of a UTI-containing preparation suited for topical application to the skin or mucosa portions susceptible to invasion of HIV is recommendable. Said skin or mucosa portions susceptible to HIV invasion include openings of the human body, such as mouth, throat, nostril, earhole, eyelid, anus, rectum, urethra and vagina, and injured portions, and vicinities thereof. The infection-inhibiting preparation is generally an external preparation and can be administered in the form of suppository, jelly, cream, cataplasma, ointment, plaster, inunction, liquid, spray, aerosol, powder for external use, etc., as the case may be. These external preparations can be prepared by a per se known method. For preventing decomposition of UTI in aqueous solution during storage, it is desirable, for example, to dissolve lyophilized UTI in water just prior to use. The UTI concentration in the infection inhibiting preparation should recommendably be adjusted depending on the dosage form so that a unit dose of 1 to 100 mg can be administered. Compositions can also be in the form of dosage units each containing 10 to 500 mg of human urine trypsin. When used in accordance with the present invention, human urine trypsin inhibitor (UTI) inhibits the binding of AIDS virus with T cells and thereby prevent the infection with said virus and/or the development of AIDS. UTI also inhibits the proliferation of said virus in the patient's body. EXAMPLE 1 UTI purified from normal human male-derived urine by Nippon Chemical Research Kabushiki Kaisha was used in this example. Its physico-chemical properties are shown below in Table 1. TABLE 1 ______________________________________ Test item Specification Test result ______________________________________ Appearance Colorless to Colorless and light yellow transparent Identification Trypsin activity To be Confirmed inhibition confirmed Confirmation To be Confirmed of human origin confirmed pH 5.0-7.5 6.54 Purity testing Specific activity .gtoreq.2,000 2,978 units/mg-p units/mg-p Heavy metals .ltoreq.10 ppm Requirement met Arsenic .ltoreq.2 ppm Requirement met Blood group Negative Negative substance Blood coagulating Not detectable Not detectable substance Urokinase activity Not detectable Not detectable Kallikrein activity .ltoreq.0.12 Ku/ml Requirement met Other proteins Not detectable Not detectable Blood pressure Negative Negative lowering substance Pyrogen test JP* Negative Sterility test JP* Negative Safety test No No abnormality abnormality HBs antigen test Negative Negative Molecular weigh 67,000 .+-. 5,000 Requirement met measurement Assay (potency) 140,056 IU/ml ______________________________________ JP = Japanese Pharmacopeia, 11th edition The process of purification includes a step of heat treatment in solution form (60.degree. C., 10 hours). Therefore, various viruses had been completely inactivated. The purity of the UTI used was very high. As shown under some of the purity test items, no proteins other than UTI was detected upon electrophoresis etc. The above UTI was used in the experiment mentioned below. LAV-1-infected CEM cells (CEM/LAV-1; 2.times.10.sup.4 cells) were used as HIV-infected cells and MOLT-4 clone 8 cells (1.times.10.sup.5 cells) as infection-free cells. When these two kinds of cells were mixedly cultured in a serum-free medium (ASF104) at 37.degree. C. in a 5% CO.sub.2 incubator, distinct syncytium formation was found after 18 hours of culture. Addition of UTI to the medium at concentrations of 30 .mu.M, 100 .mu.M, 300 .mu.M and 1 mM resulted in concentration-dependent inhibition of syncytium formation. The pictures shown in FIG. 1 show some of the results obtained. In FIG. 1, picture a for a negative control where infection-free cells (MOLT-4 clone 8) alone were cultured shows that no syncytium formation occurred. Picture b for a positive control where infection-free cells (MOLT-4 clone 8) and infected cells (CEM/LAV-1) were mixedly cultured shows that distinct syncytium formation took place. Pictures c and d are for the cases where the above-mentioned infection-free cells and infected cells were mixedly cultured with UTI added to the medium at concentrations of 1 mM and 100 .mu.M, respectively, and show that syncytium formation was inhibited in proportion to the UTI concentration. EXAMPLE 2 A solution (5,000 ml) of purified human urine trypsin inhibitor (150,000 units/ml; protein concentration 54 mg/ml) in 0.025 M phosphate buffer (pH 6.6) containing 0.9% (w/v) sodium chloride was subjected to bacterial filtration, then distributed in 2-ml portions into vials and lyophilized to give preparations for injection. EXAMPLE 3 Physiological saline (10 ml) was added to 1 g of purified, powdery human urine trypsin inhibitor (lyophilization product). After dissolution, a hydrophilic ointment base was added portionwise to the solution with kneading to give a total weight of 100 g of an ointment. As detailedly described hereinabove, the present invention provides a composition which can prevent the infection with AIDS virus and the onset of AIDS and thus can be used in the treatment of AIDS patients. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 28, 2000 Report Share Posted September 28, 2000 ---------------------------------------------------------------------------- ---- United States Patent 4,745,099 Akamatsu, et. al. May 17, 1988 ---------------------------------------------------------------------------- ---- Pharmaceutical composition for the treatment of the anemia of malignant tumors Abstract A pharmaceutical composition for the treatment of the anemia of malignant tumors comprising a therapeutically effective amount of human erythropoietin (EPO) in a parenterally acceptable vehicle is disclosed. Human EPO may be extracted from human urine or also be prepared by expressing in a host cell the gene coding for the amino acid sequence of human EPO. ---------------------------------------------------------------------------- ---- Inventors: Akamatsu; Ken-ichi (Tokyo, JP); Ono; Masayoshi (Saitama, JP). Assignee: Chugai Seiyaku Kabushiki Kaisha (Tokyo, JP). Appl. No.: 825,223 Filed: Feb. 3, 1986 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 28, 2000 Report Share Posted September 28, 2000 United States Patent 4,595,588 Baron, et. al. Jun. 17, 1986 ---------------------------------------------------------------------------- ---- Natural inhibitor that protects against viral infections Abstract A treatment and prophylaxis of viral infections in mammals is provided. The method involves administering an amount of a contact-blocking viral inhibitor (CVI) sufficient to elevate the concentration of the viral inhibitor in the mammal's tissue above the naturally occurring concentration in that same tissue. Methods for purifying and concentrating CVI are presented. The cellular viral inhibitor is characterized by broad antiviral activity, potency, reversible inhibition of viral attachment, cross species activity and molecular size. Natural levels of CVI range from 6 U/0.1 ml in tears to 400 U/0.1 ml in gastric secretions, with titers between these ranges found in colostrum, milk, plasma, saliva and urine. Biochemical characterization of the CVI indicates that it resists denaturation by heat, acid and alkali, and it exhibits a molecular size on the order of 2500 daltons. ---------------------------------------------------------------------------- ---- Inventors: Baron; (Dickinson, TX); McKerlie; M. Louese (Galveston, TX). Assignee: Board of Regents, The University of Texas System (Austin, TX). Appl. No.: 613,640 Filed: May 24, 1984 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 18, 2004 Report Share Posted April 18, 2004 - HI Corny, Well, I found it did help draw out the ooz from the sores, but it didn't do anything for the itch. After applying urine all day the smell got to me and I felt dirty so I havn't done it again. What I am using now is vitamin E and emu oil also aveeno and if that doesn't get the itch under control, I've even taken some benadryl. I know Saul told me not to, but I'm just not that tough I guess. Personally, the thought of drinking it turns my stomach. Guess I really am a westerner at heart! Gail -- In oxyplus , " ragnar redbeard " <corny100@m...> wrote: > From the absence of response to my last post re Urine Therapy, I gather it is an unpalatable subject for most. Understandable considering the misconceptions. What I have learned though, is that urine is NOT a waste product of the body. It is actually a collection of valuable elements into the kidneys that the body cannot make use of at that time. Urine is sterile and totally non-toxic. > > The kidneys are tasked with the chore of keeping the various elements in the body in balance. When an element is not needed at any one moment, it is excreted thru the kidneys. Not because it is a waste product or toxic, but because the body cannot use it at that time and there is no place to store it. > > Many elements in blood that are also found in urine have enormous medicinal value, and when reintroduced to the body, boost the body's immune defenses and stimulate healing in a way that nothing else does. There are literally thousands of beneficial compounds in urine: from Alanine to Zinc, and everything in between. This is why drug companies pay for the collection of urine. They gross billions from the sale of drugs made with urine constituents. Examples: Pergonal is a fertility drug made from human urine. 1992 sales were $855 million. Urokinase, a urine ingredient, is used in drug form as a blood clot dissolver, especially for coronary arteries. BIG $$. Urea is one of the best things to treat skin conditions, as Gail has recently experienced. It is packaged in expensive creams and lotions. Take the M out of Murine eye drops and what do you have? Yep, it's made from carbamide- another name for synthetic urea. > > Urine therapy is the ultimate in do it yourself treatment. But don't take it lightly! There are reports and double blind studies going back 100 years re it's efficacy. Urine is antibacterial, antifungal, antiviral, antineoplastic (anticancer), anticonvulsive and antispasmodic. > > With research that could fill volumes, you may be wondering why you haven't heard of Urine Therapy before. Well, urine is free and abundant and everyone has their own supply. It can't be controlled by the FDA. Reason enough? > > Corny > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 18, 2004 Report Share Posted April 18, 2004 Re: urine therapy > - > HI Corny, > > Well, I found it did help draw out the ooz from the sores, but it > didn't do anything for the itch. After applying urine all day the > smell got to me and I felt dirty so I havn't done it again. What I > am using now is vitamin E and emu oil also aveeno and if that doesn't > get the itch under control, I've even taken some benadryl. I know > Saul told me not to, but I'm just not that tough I guess. > Personally, the thought of drinking it turns my stomach. Guess I > really am a westerner at heart! > > Gail Gail, A naturopath told me that you can make a HOMEOPATHIC preparation from your urine that works as well as a concentrated dose of the original stuff. Put a few drops of your clean-catch urine into a jar of spring water and shake it. Then put a few drops of THAT batch into another jar full of clean water and shake that. Then take a few drops of THAT batch and ...well, you get the idea. I'm told this works very well. I understand your aversion to using urine. I drank my own a few years ago for a short time, and couldn't stand it. Blessings, Nenah Nenah Sylver, PhD *Information, products, and services related to healing* ========================================= THE HOLISTIC HANDBOOK OF SAUNA THERAPY is now available. Order this and also THE HANDBOOK OF RIFE FREQUENCY HEALING, at http://www.nenahsylver.com Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 18, 2004 Report Share Posted April 18, 2004 Hi Angie, What benefits are you getting from it? What do you take it for? Thanks, gail -- In oxyplus , Angie Mendez <mariposa4249@y...> wrote: > For whatever it's worth, I'm on urine therapy and drink a tablespoon or so every day! > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 19, 2004 Report Share Posted April 19, 2004 I disagree with, 1. " Urine is sterile and totally non-toxic. " and 2. " Not because it is a waste product or toxic, but because the body cannot use it at that time and there is no place to store it. " Someone please explain, because to me. 1. heavy metals are often excreted through the urine. and 2. If that were true, then your saying the body only stores things that are bad and not any of the good things. So ex: it will store PCB's and mercury, but not calcium and zinc. I believe the body to be much smarter than that. Ron urine therapy From the absence of response to my last post re Urine Therapy, I gather it is an unpalatable subject for most. Understandable considering the misconceptions. What I have learned though, is that urine is NOT a waste product of the body. It is actually a collection of valuable elements into the kidneys that the body cannot make use of at that time. Urine is sterile and totally non-toxic. The kidneys are tasked with the chore of keeping the various elements in the body in balance. When an element is not needed at any one moment, it is excreted thru the kidneys. Not because it is a waste product or toxic, but because the body cannot use it at that time and there is no place to store it. Many elements in blood that are also found in urine have enormous medicinal value, and when reintroduced to the body, boost the body's immune defenses and stimulate healing in a way that nothing else does. There are literally thousands of beneficial compounds in urine: from Alanine to Zinc, and everything in between. This is why drug companies pay for the collection of urine. They gross billions from the sale of drugs made with urine constituents. Examples: Pergonal is a fertility drug made from human urine. 1992 sales were $855 million. Urokinase, a urine ingredient, is used in drug form as a blood clot dissolver, especially for coronary arteries. BIG $$. Urea is one of the best things to treat skin conditions, as Gail has recently experienced. It is packaged in expensive creams and lotions. Take the M out of Murine eye drops and what do you have? Yep, it's made from carbamide- another name for syntheti! c urea. Urine therapy is the ultimate in do it yourself treatment. But don't take it lightly! There are reports and double blind studies going back 100 years re it's efficacy. Urine is antibacterial, antifungal, antiviral, antineoplastic (anticancer), anticonvulsive and antispasmodic. With research that could fill volumes, you may be wondering why you haven't heard of Urine Therapy before. Well, urine is free and abundant and everyone has their own supply. It can't be controlled by the FDA. Reason enough? Corny Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 10, 2004 Report Share Posted December 10, 2004 Hmmm, I was taught that urine contains the stuff our bodies cannot use, i.e. waste! > Has anyone ever heard of or practiced urine therapy and if so will you > share experiences, health benefits, procedure and any info you have. I > have Hashimoto's disease (thyroid disease) and have been told by a woman > who does reflexology to research this procedure as she has seen GREAT > health benefits from drinking 1/3 cup of her own urine per day. She says > that our own urine contains the antibodies we need for our system to heal > itself. > > Thanks for any advice. > > > mama to Beth no vax EVER Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 10, 2004 Report Share Posted December 10, 2004 Oh, dear, I just sent a post mentioning this. I've done a lot of stuff through the years but this is one that I'm holding off on until I'm dying and even then, I might choose death. I'd want to talk to someone personally who has used it. Can your reflexologist put you in touch with them? I'm presuming you've tried homeopathy and it didn't work for you? I would consider this therapy but only if I'd tried everything else which you probably have. Please let us know how you do with it if you do use it. I don't know anyone personally that's done it. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 10, 2004 Report Share Posted December 10, 2004 LOL @ anna! i feel the same way! but i do know someone personally who swears by it. i only met the person about 8 months ago and both him and his wife do it on a daily basis. he got rid of his arthritis (by the time he tried urine therapy he was unable to walk - he now goes running on a daily basis), she got rid of her ME symptoms. so there's bound to be some truth about it. i don't know whether they tried homeopathy, but i do know they tried all kinds of alternative therapies and finally hit on urine therapy and got stuck with it because it worked for both of them. it is, apparently, a matter of getting accustomed to it. but definitely beneficial from what i was told. to be honest, i'd certainly try that before resorting to pharmanazi measures! drinking your own urine can't possibly be as bad as taking government sanctioned drugs... claudia --- DrCrandall <drcrandall@...> wrote: > Oh, dear, I just sent a post mentioning this. > I've done a lot of stuff through the years but > this is one that I'm holding off on until I'm > dying and even then, I might choose death. I'd > want to talk to someone personally who has used > it. Can your reflexologist put you in touch with > them? I'm presuming you've tried homeopathy and > it didn't work for you? I would consider this > therapy but only if I'd tried everything else > which you probably have. Please let us know how > you do with it if you do use it. I don't know > anyone personally that's done it. > > > > [Non-text portions of this message have been > removed] > > ===== http://www.himalayasalt.co.uk http://www.he-ed.org.uk " We shall no longer hang on to the tails of public opinion or to a non- existent authority on matters utterly unknown and strange. We shall gradually become experts ourselves in the mastery of the knowledge of the Future. " Wilhelm Reich Send instant messages to your online friends http://uk.messenger. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 11, 2004 Report Share Posted December 11, 2004 I have heard of a monk that has done this most of his life and he is like 100+ years and that is why it was mentioned, he swears it is his secret to long healthy life. I would only do it as a LAST measure too. My husband said as I just mentioned it, and he said when Ghandi was imprisoned by the British, that is how he lived through the prison sentence, I didn't know that, but he heard that. Western NY RE: Urine Therapy > > LOL @ anna! i feel the same way! but i do know someone > personally who swears by it. i only met the person > about 8 months ago and both him and his wife do it on > a daily basis. he got rid of his arthritis (by the > time he tried urine therapy he was unable to walk - he > now goes running on a daily basis), she got rid of her > ME symptoms. so there's bound to be some truth about > it. i don't know whether they tried homeopathy, but i > do know they tried all kinds of alternative therapies > and finally hit on urine therapy and got stuck with it > because it worked for both of them. it is, apparently, > a matter of getting accustomed to it. but definitely > beneficial from what i was told. to be honest, i'd > certainly try that before resorting to pharmanazi > measures! drinking your own urine can't possibly be as > bad as taking government sanctioned drugs... > claudia > > > --- DrCrandall <drcrandall@...> wrote: > > Oh, dear, I just sent a post mentioning this. > > I've done a lot of stuff through the years but > > this is one that I'm holding off on until I'm > > dying and even then, I might choose death. I'd > > want to talk to someone personally who has used > > it. Can your reflexologist put you in touch with > > them? I'm presuming you've tried homeopathy and > > it didn't work for you? I would consider this > > therapy but only if I'd tried everything else > > which you probably have. Please let us know how > > you do with it if you do use it. I don't know > > anyone personally that's done it. > > > > > > > > [Non-text portions of this message have been > > removed] > > > > > > ===== > http://www.himalayasalt.co.uk > http://www.he-ed.org.uk > > " We shall no longer hang on to the tails of public opinion or to a non- existent authority on matters utterly unknown and strange. We shall gradually become experts ourselves in the mastery of the knowledge of the Future. " Wilhelm Reich > > Send instant messages to your online friends http://uk.messenger. > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 11, 2004 Report Share Posted December 11, 2004 Wow! I guess I'm learning something new here!!! It just doesn't make sense to me though....why would the body get rid of something so valuable????? > I have heard of a monk that has done this most of his life and he is like > 100+ years and that is why it was mentioned, he swears it is his secret to > long healthy life. > > I would only do it as a LAST measure too. > > My husband said as I just mentioned it, and he said when > Ghandi was imprisoned by the British, that is how he lived through the > prison sentence, I didn't know that, but he heard that. > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 11, 2004 Report Share Posted December 11, 2004 Here's a link with more information than you probably ever wanted to know about urine therapy! LOL http://www.shirleys-wellness-cafe.com/urine.htm I'd be interested in hearing what Sheri's opinion of it is... Kay **************** LOL @ anna! i feel the same way! but i do know someone personally who swears by it. i only met the person about 8 months ago and both him and his wife do it on a daily basis. he got rid of his arthritis (by the time he tried urine therapy he was unable to walk - he now goes running on a daily basis), she got rid of her ME symptoms. so there's bound to be some truth about it. i don't know whether they tried homeopathy, but i do know they tried all kinds of alternative therapies and finally hit on urine therapy and got stuck with it because it worked for both of them. it is, apparently, a matter of getting accustomed to it. but definitely beneficial from what i was told. to be honest, i'd certainly try that before resorting to pharmanazi measures! drinking your own urine can't possibly be as bad as taking government sanctioned drugs... claudia Quote Link to comment Share on other sites More sharing options...
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