Article regarding celiac disease developing later in life study

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Celiac disease can develop later in life: Study

By Caroline -, 28-Sep-2010

Related topics: Science & Nutrition

The incidence of celiac disease has doubled every 15 years since 1974 and is

becoming more prevalent in the elderly, claims new research from the University

of land's Center for Celiac Research.

Celiac disease, an autoimmune disorder triggered by gluten – the protein in

wheat, barley, rye and spelt – is estimated to affect about one in every 133

Americans. This latest study followed 3,511 subjects who gave blood samples in

1974, 1989 and then every two to three years to 2007. It tested blood serum for

celiac disease autoimmunity, and found that the incidence of celiac disease in

the sample group rose from one in 501 in 1974, to one in 219 in 1989.

It adds to the theory that celiac disease can emerge at any time, rather than

predominantly in childhood, the researchers wrote.

Lead author of the paper and co-director of the Center for Celiac Research,

Carlo Catassi, of the Universita Politecnica delle Marche in Italy, said:

" You're not necessarily born with celiac disease. Our findings show that some

people develop celiac disease quite late in life. "

However, the authors wrote that the reasons for celiac disease emerging later in

life are currently unclear.

" The amount and the quality of ingested gluten, type and duration of wheat dough

fermentation, the spectrum of intestinal microbiota and its changes over time,

enteric infections, and stressors in general are all possible switches of the

tolerance/immune response balance. However, further studies are required to

clarify the relevance of these factors in causing loss of gluten tolerance, "

they wrote.

The researchers added that if it is possible to pinpoint the reason why

increasing numbers of adults appear to be developing celiac disease, it may be

possible to prevent its onset. At present, the only available treatment for the

autoimmune disorder is avoidance of gluten-containing foods.

Source: ls of Medicine

Published online ahead of print

" Natural history of celiac disease autoimmunity in a USA cohort followed since

1974 "

Authors: Carlo Catassi, Debby Kryszak, Bushra Bhatti, Craig Sturgeon, Kathy

Helzlsouer, L. Clipp, Gelfond, Elaine Puppa, Sferruzza and

Alessio Fasano.

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Joe

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