Re: book suggestion for thyroid/gluten connection

February 3, 2011

While I have reservations about the appropriate expertise of naturopaths in serious disease issues, the correlations between thyroid problems and celiac have been extensively researched, as is exemplified by the below abstract from pubmed.gov. I think two important things must be considered for those with celiac and thyroid problems: assiduously follow a gluten free diet and realize that there are other conditions that could cause the thyroiditis.Thyroid. 2008 Nov;18(11):1171-8.Tissue

transglutaminase antibodies in individuals with celiac disease bind to thyroid follicles and extracellular matrix and may contribute to thyroid

dysfunction.Naiyer AJ, Shah J, L, Kim SY, Ciaccio EJ, Cheng J, Manavalan S, Bhagat G, Green PH.Department

of Medicine, Celiac Disease Center at Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA.Comment in:Nat Rev Endocrinol. 2009 Apr;5(4):190-1. AbstractBACKGROUND: Individuals

with active celiac disease (CD+) have an increased incidence of thyroid

dysfunction, which improves on a gluten-free diet (CD-). We investigated whether tissue transglutaminase-2 IgA antibodies (anti-TGase II) present in sera of patients with celiac disease react with thyroid tissue and possibly contribute to thyroid disease.METHODS: Serum

from 40 active celiac patients taken before a gluten-free diet (CD+), 46 patients on a gluten-free diet (CD-), 40 normal controls (NC), and 25

with Crohn's disease (CROHN) was used. All sera were screened for antithyroperoxidase antibodies (TPO-AB) and thyroglobulin antibodies (TG-AB), and indirect immunofluorescence (IIF) was performed on primate thyroid tissue sections using TPO-AB- and TG-AB-negative sera.RESULTS: IIF

with thyroid seronegative, anti-TGase II-positive CD+ sera (n = 23) demonstrated staining of thyroid follicular cells and extracellular matrix, in an identical pattern with monoclonal anti-human TGase II antibody. Evidence of TGase II as the antigen in thyroid tissue was supported by elimination of the IIF pattern when sera were depleted of anti-TGase II by pretreatment with human recombinant TGase II. No staining of thyroid tissue was observed when sera from CD+ patients that

were negative for TGase II antibodies, or sera from NC subjects were used. Thyroid antibodies were found in 43% of CD+ patients, significantly higher than NC and CROHN patients (p < 0.0001). In addition, a positive correlation was observed between anti-TGase II and TPO-AB titers (p = 0.0001; r = 0.63).CONCLUSIONS: Anti-TGase

II antibodies bind to TGase II in thyroid tissue, and titers correlate with TPO antibody titers. These findings suggest that anti-TGase II antibodies could contribute to the development of thyroid disease in celiac disease.PMID: 19014325 [PubMed - indexed for MEDLINE] HogleFreelance academic librarianInstructor, online researchEmail: jjhogle@...Web: (under de- and re-construction) www.blueroom.comReality ain't what you think it isArt Graphics & Photographs[http://www.blueroom.com/realityaint.htm]From: li_cynthia <cynth.li@...> Sent: Thu, February 3, 2011 9:18:52 AMSubject: [ ] book suggestion for thyroid/gluten connection

I should add that a book that might be helpful to those of you still

with thyroid symptoms despite doctors telling you that you're fine is

Dr. Kharrazian's "Why Do I Still Have Thyroid Symptoms?" He is a

naturopath and explains in great detail the differences between

various thyroid test results and also about the inflammation that the

thyroid undergoes. He strongly recommends everyone with

autoimmune-type (Hashimoto's & /or postpartum) thyroiditis remove

gluten ( & possibly dairy) for life. Here is more info:http://www.thyroidbook.com/about-dr-kharrazian.html

And for those of you that said you are gluten free but still requiring

high & /or escalating doses of thyroid supplement, if you are not

already dairy free, you should think about either doing an elimination

test (2 weeks off dairy all together, then reintroduce gently and see

if there are any symptoms-- can be anything from GI symptoms to a

change in energy levels, or any noticeable difference, really) or get

tested for it. www.enterolab does stool sampling for dairy

sensitivity, which is a different test than a dairy "allergy" blood

test (the latter may not pick up the sensitivity). It is estimated

that 30% of celiacs have a concurrent cow milk allergy, and that up to

60% have a concurrent one with goat milk, so you would need to

eliminate all dairy, including butter. Goat milk sensitivity testing

is not available, to my knowledge, clinically, b/c its consumption is

not common enough to develop a commercial test for it. This is

information I have gathered through reading papers out of Europe where

they have conducted specific research to test for this.

Hope this is helpful to some of you!

February 3, 2011

Just wanted to mention that I recently (within the last few weeks) cut out dairy and I feel like I have TOO much energy now. It's really amazing to see the difference with no dairy. I had tried to cut it all out except butter and didn't have good results. This time got rid of butter too and I'm amazed. And I'm losing lots of weight (good thing, I really needed to lose weight) and just feel better.JasmineFrom: li_cynthia <cynth.li@...>Subject: [ ] book suggestion for thyroid/gluten connection Date: Thursday, February 3, 2011, 9:18 AM