Re: Fat is a Direct Route to Aging

[Guest guest]

Warren: once I'm dead, I don't give a rat's ass how young I

appear......sorry couldn't resist :-)))))

on 3/1/2004 11:28 AM, Warren at warren.taylor@... wrote:

> Even after calorie-restricted

> animals die, they appear young physically.

[Guest guest]

hear! hear!

now you spic my language.

regards.

----- Original Message -----

From: Francesca Skelton

Sent: Monday, March 01, 2004 10:41 AM

Subject: Re: [ ] Fat is a Direct Route to Aging

Warren: once I'm dead, I don't give a rat's ass how young Iappear......sorry couldn't resist :-)))))on 3/1/2004 11:28 AM, Warren at warren.taylor@... wrote:> Even after calorie-restricted> animals die, they appear young physically.

[Guest guest]

Hi All,

See:

Cell. 2004 Feb 20;116(4):551-63.

Mammalian SIRT1 Represses Forkhead Transcription Factors.

Motta MC, Divecha N, Lemieux M, Kamel C, Chen D, Gu W, Bultsma Y,

McBurney M,Guarente L.

We speculate how downregulating these two classes of damage-

responsive mammalian factors may favor long lifespan under certain

environmental conditions, such as calorie restriction.

PMID: 14980222 [PubMed - in process]

Cheers, Al Pater.

> http://www.wired.com/news/business/0,1367,62169,00.html

>

> See Bottom part of page ...

>

> People who practice calorie restriction are betting that's

> the case [that they will stay young; live longer], although

> it's never been proven in a study to be true for humans.

> But worms, mice and primates all have been shown to appear

> to be younger on severe diets. Even after calorie-restricted

> animals die, they appear young physically.

>

> " They [CR Animals] blow right past maximum number of months

> or years they're supposed to live, " said. " When they

> finally die, researchers can barely find out reasons why

> they died. Their systems and all of their physical aspects

> appear to be that of a much, much younger animal. "

> The effects of calorie restriction are remarkable,

> researchers say, because the process protects all of the

> cells in the body.

>

> " A major point about calorie restriction is that it should

> simply be viewed as something that makes you live longer

> but also an antidote of many diseases associated with

> aging, " including Alzheimer's, diabetes, cardiovascular

> disease and osteoporosis, Guarente said.

>

> The whole-body, or systemic, effect of calorie restriction

> led the MIT researchers directly to their next project.

> Guarente's lab will study the relationship between diet,

> fat and aging. A key outcome of calorie restriction, the

> researchers figure, is the disappearance of fat. And fat

> cells make hormones, which act systemically.

>

> " Fat is a direct route connecting diet to the rate of aging

> of all cells, " Guarente said.

>

> Message: Stay CR skinny.

>

> -- Warren