Re: Biomarkers of Longevity

[Guest guest]

Dunno 'bout Warren's statement, but the recent primate CR study:

Science. 2002 Aug 2;297(5582):811. Related Articles, Links

Biomarkers of caloric restriction may predict longevity in humans.

Roth GS, Lane MA, Ingram DK, Mattison JA, Elahi D, Tobin JD, Muller D,

Metter EJ.

National Institute on Aging, 5600 Shock Drive, Baltimore, MD 21224,

USA.

PMID: 12161648 [PubMed - indexed for MEDLINE]

appears to show HIGHER DHEA-S levels correlate with increased longevity:

http://www.sciencemag.org/content/vol297/issue5582/images/large/se3020741001.jpe\

g

http://snipurl.com/4svg

The study in full:

http://www.sciencemag.org/cgi/content/full/297/5582/811

http://snipurl.com/4svh

>From: " Rodney " <perspect1111@...>

>Reply-

>

>Subject: [ ] Biomarkers of Longevity

>Date: Sun, 29 Feb 2004 21:41:34 -0000

>

>Hi folks:

>

>I am confused. (Not for the first time). Do the following two posts

>say the same thing? Or the opposite? If the same thing then why do

>I have the impression they are the opposite? If they are the

>opposite, which should we accept?

>

> " ......... low levels of DHEAS (which is related to low

>testosterone levels) showed the most remarkable and distinct

>predictive correlation with longevity. " - Warren # 10410

>

> " ................. " CR attenuated the age-associated decline in both

>dehydroepiandrosterone (DHEA) ...in males. ... PMID: 12543259

>[PubMed - indexed for MEDLINE] " - Al # 10423

>

>This seems like it may be an important detail for some.

>

>Rodney.

>

[Guest guest]

Dis study also appears to show retained higher levels of DHEA = increased

longevity (i.e. keep the DHEA up!):

Exp Gerontol. 2003 Jan-Feb;38(1-2):35-46. Related Articles, Links

Calorie restriction in rhesus monkeys.

Mattison JA, Lane MA, Roth GS, Ingram DK.

Intramural Research Program, Gerontology Research Center, National Institute

on Aging, NIH, 5600 Shock Drive, Baltimore, MD 21224, USA.

mattisonj@...

Calorie restriction (CR) extends lifespan and reduces the incidence and age

of onset of age-related disease in several animal models. To determine if

this nutritional intervention has similar actions in a long-lived primate

species, the National Institute on Aging (NIA) initiated a study in 1987 to

investigate the effects of a 30% CR in male and female rhesus macaques

(Macaca mulatta) of a broad age range. We have observed physiological

effects of CR that parallel rodent studies and may be predictive of an

increased lifespan. Specifically, results from the NIA study have

demonstrated that CR decreases body weight and fat mass, improves

glucoregulatory function, decreases blood pressure and blood lipids, and

decreases body temperature. Juvenile males exhibited delayed skeletal and

sexual maturation. Adult bone mass was not affected by CR in females nor

were several reproductive hormones or menstrual cycling. CR attenuated the

age-associated decline in both dehydroepiandrosterone (DHEA) and melatonin

in males. Although 81% of the monkeys in the study are still alive,

preliminary evidence suggests that CR will have beneficial effects on

morbidity and mortality. We are now preparing a battery of measures to

provide a thorough and relevant analysis of the effectiveness of CR at

delaying the onset of age-related disease and maintaining function later

into life.

PMID: 12543259 [PubMed - indexed for MEDLINE]

>From: " Rodney " <perspect1111@...>

>Reply-

>

>Subject: [ ] Biomarkers of Longevity

>Date: Sun, 29 Feb 2004 21:41:34 -0000

>

>Hi folks:

>

>I am confused. (Not for the first time). Do the following two posts

>say the same thing? Or the opposite? If the same thing then why do

>I have the impression they are the opposite? If they are the

>opposite, which should we accept?

>

> " ......... low levels of DHEAS (which is related to low

>testosterone levels) showed the most remarkable and distinct

>predictive correlation with longevity. " - Warren # 10410

>

> " ................. " CR attenuated the age-associated decline in both

>dehydroepiandrosterone (DHEA) ...in males. ... PMID: 12543259

>[PubMed - indexed for MEDLINE] " - Al # 10423

>

>This seems like it may be an important detail for some.

>

>Rodney.

>

[Guest guest]

Those wacky, persisting Okinawans also have high DHEA:

Asia Pac J Clin Nutr. 2001;10(2):165-71. Related Articles, Links

Implications from and for food cultures for cardiovascular disease:

longevity.

Suzuki M, Wilcox BJ, Wilcox CD.

Okinawa Research Center for Longevity Science, Naha. Mksuzuki@...

A healthy cardiovascular system, with minimal arteriosclerosis, good

endothelial function and well-compensated ventricular function has been

observed at advanced ages, and linked to a healthy lifestyle. This has

consisted of a plant-based diet, low in salt and fat, with monounsaturates

as the principal fat. Other healthy lifestyle factors include regular

physical activity (farming and traditional dance) and minimal tobacco use.

The associated negative risk factors are low homocysteine, healthy

cholesterol profile (Total:HDL ratio less than 3.5) and reasonable blood

pressures throughout the life cycle. Hormone-dependent cancers including

breast, ovary, prostate and colon and osteoporotic complications, such as

hip fracture rates, are also less frequent compared to the west. Protective

factors may include high anti-oxidant consumption, mainly flavonoids and

carotenoids, through a high vegetable (e.g., onions) and soy intake. Related

biological observations include low lipid peroxide, high superoxide

dismutase activity and high serum hydroxyproline, a marker of bone

formation. Dehydroepiandrosterone (DHEA) and its hormonal byproducts

testosterone and oestrogen appear to be high in Okinawan serum compared with

age-matched Americans, possibly reflecting a slower age-associated decline

in the sex hormone axis in Okinawans. This may be linked to better

cardiovascular and overall health. Further study is needed to delineate the

reasons behind the impressive cardiovascular and overall health of the

Okinawans.

Publication Types:

Review

Review, Tutorial

PMID: 11710359 [PubMed - indexed for MEDLINE]

>From: " Rodney " <perspect1111@...>

>Reply-

>

>Subject: [ ] Biomarkers of Longevity

>Date: Sun, 29 Feb 2004 21:41:34 -0000

>

>Hi folks:

>

>I am confused. (Not for the first time). Do the following two posts

>say the same thing? Or the opposite? If the same thing then why do

>I have the impression they are the opposite? If they are the

>opposite, which should we accept?

>

> " ......... low levels of DHEAS (which is related to low

>testosterone levels) showed the most remarkable and distinct

>predictive correlation with longevity. " - Warren # 10410

>

> " ................. " CR attenuated the age-associated decline in both

>dehydroepiandrosterone (DHEA) ...in males. ... PMID: 12543259

>[PubMed - indexed for MEDLINE] " - Al # 10423

>

>This seems like it may be an important detail for some.

>

>Rodney.

>

[Guest guest]

Hi All,

High DHAE-S was found in CRers in files that I am aware of from

person information and the Western University of St. Louis experiment

of CRers.

> Dunno 'bout Warren's statement, but the recent primate CR study:

>

> Science. 2002 Aug 2;297(5582):811. Related Articles, Links

>

>

> Biomarkers of caloric restriction may predict longevity in humans.

>

> Roth GS, Lane MA, Ingram DK, Mattison JA, Elahi D, Tobin JD, Muller

D,

> Metter EJ.

>

> National Institute on Aging, 5600 Shock Drive, Baltimore, MD

21224,

> USA.

>

> PMID: 12161648 [PubMed - indexed for MEDLINE]

>

>

>

> appears to show HIGHER DHEA-S levels correlate with increased

longevity:

>

>

http://www.sciencemag.org/content/vol297/issue5582/images/large/se3020

741001.jpeg

>

> http://snipurl.com/4svg

>

> The study in full:

>

> http://www.sciencemag.org/cgi/content/full/297/5582/811

>

>

> http://snipurl.com/4svh

>

>

> >From: " Rodney " <perspect1111@y...>

> >Reply-

> >

> >Subject: [ ] Biomarkers of Longevity

> >Date: Sun, 29 Feb 2004 21:41:34 -0000

> >

> >Hi folks:

> >

> >I am confused. (Not for the first time). Do the following two

posts

> >say the same thing? Or the opposite? If the same thing then why

do

> >I have the impression they are the opposite? If they are the

> >opposite, which should we accept?

> >

> > " ......... low levels of DHEAS (which is related to low

> >testosterone levels) showed the most remarkable and distinct

> >predictive correlation with longevity. " - Warren # 10410

> >

> > " ................. " CR attenuated the age-associated decline in

both

> >dehydroepiandrosterone (DHEA) ...in males. ... PMID: 12543259

> >[PubMed - indexed for MEDLINE] " - Al # 10423

> >

> >This seems like it may be an important detail for some.

[Guest guest]

Hi :

Thanks for those links. The temperature and insulin charts are

pretty much self explanatory. But I don't quite understand the third

(left side) chart below. And it seems to be the most important of

the three as it clearly has by far the best survival curve.

What does it mean when they label the left axis " Percent of initial

DHEAS value " ??? (I cannot access the full study. Just the charts.)

In other words, why do the CR and control monkeys both show

an 'increase' from the 'initial values'? And in what way were the

initial conditions different from the later conditions? Do you see

why I am having difficulty figuring out that third chart?

(I don't want to put you to a lot of trouble over this, but if there

is a simple answer ...........)

So it SEEMS to be saying that CR elevates testosterone? Which is the

opposite of what I had previously understood, and presumably good

news if it is correct?

Rodney.

> Dunno 'bout Warren's statement, but the recent primate CR study:

>

> Science. 2002 Aug 2;297(5582):811. Related Articles, Links

>

>

> Biomarkers of caloric restriction may predict longevity in humans.

>

> Roth GS, Lane MA, Ingram DK, Mattison JA, Elahi D, Tobin JD, Muller

D,

> Metter EJ.

>

> National Institute on Aging, 5600 Shock Drive, Baltimore, MD

21224,

> USA.

>

> PMID: 12161648 [PubMed - indexed for MEDLINE]

>

> appears to show HIGHER DHEA-S levels correlate with increased

longevity:

> http://snipurl.com/4svh

[Guest guest]

Hi :

DUH!!! Forget that last post. Now I understand it. For those on CR

there was a negligible decline in DHEAS over the 25 year period

(compared with a sizeable decline for those fully fed). And

longevity was much more closely associated with maintaining a high

level of DHEA than it was with reduced temperature or insulin.

Thanks again. Great stuff!

Rodney.

> > Dunno 'bout Warren's statement, but the recent primate CR study:

> >

> > Science. 2002 Aug 2;297(5582):811. Related Articles, Links

> >

> >

> > Biomarkers of caloric restriction may predict longevity in humans.

> >

> > Roth GS, Lane MA, Ingram DK, Mattison JA, Elahi D, Tobin JD,

Muller

> D,

> > Metter EJ.

> >

> > National Institute on Aging, 5600 Shock Drive, Baltimore,

MD

> 21224,

> > USA.

> >

> > PMID: 12161648 [PubMed - indexed for MEDLINE]

> >

> > appears to show HIGHER DHEA-S levels correlate with increased

> longevity:

>

> > http://snipurl.com/4svh

[Guest guest]

--- In , " Rodney " <perspect1111@y...>

wrote:

> Hi :

[snip]

>

> So it SEEMS to be saying that CR elevates testosterone? Which is

the

> opposite of what I had previously understood, and presumably good

> news if it is correct?

Hi All,

As I understand it, CR results in higher late life testosterone.

Cheers, Al Pater

[Guest guest]

Dunno:

Horm Metab Res. 2004 Jan;36(1):27-33. Related Articles, Links

Effects of undernutrition on serum and testicular testosterone levels and

sexual function in adult rats.

Marcelly De Souza Santos A, Ferraz MR, Teixeira CV, Sampaio FJ, Da Fonte

Ramos C.

Urogenital Research Unit, State University of Rio de Janeiro, Rio de

Janeiro, Brazil.

The aim of this study was to evaluate testosterone concentrations, sexual

behavior, and androgen receptor protein level in the testes of rats

submitted to protein- and energy-restricted diets during 30 days. Adult male

Wistar rats were assigned to one of the following groups: © control, diet

with 23 % of protein; (PR) protein-restricted, diet with 8 % of protein;

(ER) energy-restricted, diet with 23 % of protein in restricted quantities.

Mount number, ejaculation latencies and copulatory efficiency were evaluated

to determine sexual behavior. At the end of the experiment, the animals were

sacrificed to determine serum and testicular testosterone concentrations as

well as testicular androgen receptor protein level. Compared to the C group,

the ER group presented a significant decrease in body (36 %), testis (20 %)

and epididymis (14 %) weights in serum (78 %) and testicular (68 %)

testosterone concentrations as well as in copulatory efficiency (26 %). On

the other hand, the ER group presented a significant increase in mount

number (114 %) and ejaculatory latency (62 %). The androgen receptor protein

levels were significantly reduced in both PR and ER groups (41 % and 74 %,

respectively). This is the first paper to demonstrate that the effect of

undernutrition on reproduction is not related to reduced protein intake but

caloric restriction. Also, in caloric restriction, there is a relationship

between sex behavior, androgen receptors, and testosterone concentration.

PMID: 14983403 [PubMed - in process]

Also, a number of CR practitioners have reported decreased libido, which may

correlate with lower T.

>From: " old542000 " <apater@...>

>Reply-

>

>Subject: [ ] Re: Biomarkers of Longevity

>Date: Mon, 01 Mar 2004 14:38:22 -0000

>

>--- In , " Rodney " <perspect1111@y...>

>wrote:

> > Hi :

> [snip]

> >

> > So it SEEMS to be saying that CR elevates testosterone? Which is

>the

> > opposite of what I had previously understood, and presumably good

> > news if it is correct?

>

>Hi All,

>

>As I understand it, CR results in higher late life testosterone.

>

>Cheers, Al Pater

>

[Guest guest]

Hi ROdney,

Hope I do not respond if the reponse was made by someone earlier.

Getting less than the RDA of protein may not be good.

Cheers, Al Pater.

> Dunno:

>

>

> Horm Metab Res. 2004 Jan;36(1):27-33. Related Articles, Links

>

>

> Effects of undernutrition on serum and testicular testosterone

levels and

> sexual function in adult rats.

>

> Marcelly De Souza Santos A, Ferraz MR, Teixeira CV, Sampaio FJ, Da

Fonte

> Ramos C.

>

[snip]

> Adult male

> Wistar rats were assigned to one of the following groups: ©

control, diet

> with 23 % of protein; (PR) protein-restricted, diet with 8 % of

protein;

> (ER) energy-restricted, diet with 23 % of protein in restricted

quantities.

[snip]

>

> PMID: 14983403 [PubMed - in process]

>

>

> Also, a number of CR practitioners have reported decreased libido,

which may

> correlate with lower T.

[Guest guest]

BUT that subject of RDA is not an easy one, especially at lower caloric intakes.

Regards.

----- Original Message -----

From: old542000

Sent: Tuesday, March 02, 2004 1:23 PM

Subject: [ ] Re: Biomarkers of Longevity

Hi ROdney,Hope I do not respond if the reponse was made by someone earlier.Getting less than the RDA of protein may not be good.Cheers, Al Pater.> Dunno:> > > Horm Metab Res. 2004 Jan;36(1):27-33. Related Articles, Links> > > Effects of undernutrition on serum and testicular testosterone levels and > sexual function in adult rats.> > Marcelly De Souza Santos A, Ferraz MR, Teixeira CV, Sampaio FJ, Da Fonte > Ramos C.> [snip]> Adult male > Wistar rats were assigned to one of the following groups: © control, diet > with 23 % of protein; (PR) protein-restricted, diet with 8 % of protein; > (ER) energy-restricted, diet with 23 % of protein in restricted quantities. [snip]