Guest guest Posted February 21, 2004 Report Share Posted February 21, 2004 Hi again, a bit more de-lurking... I found the article linked below very interesting: http://www.jefallbright.net/node/view/1855 The very short version is that they did some experiments and found that CR activates the SIR2 gene (silenced information regulator gene). This gene makes Sir2 protein which is normally activated by Coenzyme NAD. Another Coenzyme NADH inhibits Sir2 protien by blocking NAD. I'm not clear on how the Sir2 protein fits in or what it does, but... During CR, NADH levels decline. In cells NADH stimulates production of ATP (Adenosine triphosphate) - the compound that represents chemical energy in cells. Less NADH in a cell = less ATP (stored energy) in the cell. ATP is one of the monomers used in the synthesis of RNA and, after conversion to deoxyATP (dATP), DNA. Is this making any sense re: how CR works? Just wanted to hear what others think of this line of reseach? One thought I had (and maybe I'm way off base here) but... calories = energy fewer calories = less NADH less NADH means less ATP less ATP = less energy burned in cells = longer life of cells This almost sounds like the cells act like batteries, the less power you use the longer it lasts? (cells can only process so much energy before they burn out?) But that sounds way to simplistic. Any comments/discussion? Quote Link to comment Share on other sites More sharing options...
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