Guest guest Posted February 19, 2004 Report Share Posted February 19, 2004 I don't believe so, & perhaps we may never know. The article(s) described a tight restriction on the plant and land that grows them ... and pfizer is making synthetic version. One author of an article tried the real plant & said it worked great. Francesca Skelton wrote: >did we ever come to a conclusion as to whether this (Hoodia) works? > > >on 2/18/2004 8:27 PM, apricot85 at apricot85@... wrote: > > >>Perhaps the DARPA folks were inspired by the all those articles about >>Hoodia cactus >> >> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 19, 2004 Report Share Posted February 19, 2004 Hard to know, although, apparently, the studies are in progress. Perhaps one might try to obtain some " real " hoodia? http://www.cybernewsnetwork.com/TrimSpa.htm If such is available..... >From: Francesca Skelton <fskelton@...> >Reply- >< > >Subject: [ ] Hoodia >Date: Wed, 18 Feb 2004 20:37:03 -0500 > >did we ever come to a conclusion as to whether this (Hoodia) works? > > >on 2/18/2004 8:27 PM, apricot85 at apricot85@... wrote: > > > Perhaps the DARPA folks were inspired by the all those articles about > > Hoodia cactus > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 22, 2004 Report Share Posted November 22, 2004 What about cultivating one's own hoodia crop? On Sun, 21 Nov 2004 20:07:18 -0500, Francesca Skelton <fskelton@...> wrote: > > " 60 Minutes " ran a segment about this plant in the cactus family which > depresses appetite. Apparently no side effects. But won't be available in > any usable form til about 2008. > > What's now available is a rip-off with not enough hoodia to cause any > appetite suppression. > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 22, 2004 Report Share Posted November 22, 2004 > > > > " 60 Minutes " ran a segment about this plant in the cactus family which > > depresses appetite. Apparently no side effects. But won't be available in > > any usable form til about 2008. > > > > What's now available is a rip-off with not enough hoodia to cause any > > appetite suppression. > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 22, 2004 Report Share Posted November 22, 2004 NOW Foods sells a hoodia containing supplement. They generally have a strong reputation for quality and I would be surprised if it did not contain what the labeling states. Perhaps there is just not enough hoodia in these supplements. On Mon, 22 Nov 2004 12:56:27 -0000, merlinspinnewin <joopes@...> wrote: > > > > > > > > > " 60 Minutes " ran a segment about this plant in the cactus family > which > > > depresses appetite. Apparently no side effects. But won't be > available in > > > any usable form til about 2008. > > > > > > What's now available is a rip-off with not enough hoodia to cause > any > > > appetite suppression. > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 22, 2004 Report Share Posted November 22, 2004 That was exactly the reason given that the supplements now on the market were ineffective. Not enough hoodia to do diddlysquat. Til now the FDA didn't have to regulate. Now that a company is actually going to market an amount which will actually work, the FDA is involved. Growing it is not easy. They showed the difficulty of finding it in the wild and the current " farming " of it. It's not like growing sprouts or some other easy plant. on 11/22/2004 8:38 AM, Dowling at christopher.a.dowling@... wrote: > NOW Foods sells a hoodia containing supplement. They generally have a > strong reputation for quality and I would be surprised if it did not > contain what the labeling states. Perhaps there is just not enough > hoodia in these supplements. > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 22, 2004 Report Share Posted November 22, 2004 Hoodia is an " old medicine " used by the Sans tribe in Africa to decrease appetite and enhance hydration. It is used on war marches or long hikes. A British company, PhytoPharm PLC has isolated a saponon from hoodia, it is labeled P57. Pfizer bought the commercial rights for this " extraxT " and the patents from PhytoPharm PLC for ~$35 million. Studies in animals and humans demonstrate efficacy for appetite decrease and weight loss. Human studies have only been Phase I. Pfizer has decided not to develop it further and has reverted back the full rights to Phytopharm PLC for the product (and all of its patents). It appears that all of the companies who sell it as a dietary supplement are both in violation of the patnts and FDA law as related to filing for a New Dietary Ingredient notification (similar to a GRAS filing with the FDA). Phytopharm is continuing to do clinical trials with P57 and just presented some data at NAASO last week. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 22, 2004 Report Share Posted November 22, 2004 And who needs an appetite suppressant anyway? We need fat storage suppressants and fat "burning" activators. Isn't anyone ever going to work the real problem? Regards ----- Original Message ----- From: Jeff Novick Sent: Monday, November 22, 2004 8:50 AM Subject: RE: [ ] Hoodia Hoodia is an "old medicine" used by the Sans tribe in Africa to decrease appetite and enhance hydration. It is used on war marches or long hikes. A Britishcompany, PhytoPharm PLC has isolated a saponon from hoodia, it is labeled P57. Pfizer bought the commercial rights for this "extraxT" and the patents from PhytoPharm PLC for ~$35 million. Studies in animals and humans demonstrate efficacy for appetite decrease and weight loss. Human studies have only been Phase I. Pfizer has decided not to develop it further and has reverted back the full rights to Phytopharm PLC for the product (and all of its patents). It appears that all of the companies who sell it as a dietary supplement are both in violation of the patnts and FDA law as related to filing for a New Dietary Ingredientnotification (similar to a GRAS filing with the FDA). Phytopharm is continuing to do clinical trials with P57 and just presented some data at NAASO lastweek. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 22, 2004 Report Share Posted November 22, 2004 What we really need is genomically based rejuvenation. On Mon, 22 Nov 2004 09:08:10 -0600, jwwright <jwwright@...> wrote: > > And who needs an appetite suppressant anyway? We need fat storage > suppressants and fat " burning " activators. Isn't anyone ever going to work > the real problem? > > Regards > > > > ----- Original Message ----- > From: Jeff Novick > > Sent: Monday, November 22, 2004 8:50 AM > Subject: RE: [ ] Hoodia > > Hoodia is an " old medicine " used by the Sans tribe in Africa to decrease > appetite and enhance hydration. It is used on war marches or long hikes. A > British > company, PhytoPharm PLC has isolated a saponon from hoodia, it is labeled > P57. Pfizer bought the commercial rights for this " extraxT " and the patents > from PhytoPharm PLC for ~$35 million. Studies in animals and humans > demonstrate efficacy for appetite decrease and weight loss. Human studies > have only been Phase I. Pfizer has decided not to develop it further and > has reverted back the full rights to Phytopharm PLC for the product (and all > of its patents). It appears that all of the companies who sell it as a > dietary supplement are both in violation of the patnts and FDA law as > related to filing for a New Dietary Ingredient > notification (similar to a GRAS filing with the FDA). Phytopharm is > continuing to do clinical trials with P57 and just presented some data at > NAASO last > week. > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 22, 2004 Report Share Posted November 22, 2004 Tough call... do we distrust 60 minutes or the Supplement industry. I don't hold either in very high regard and in this case there are plenty of questions... like why did Pfizer bail if it was such a slam dunk? I suspect Hoodia may really work but you probably have to visit the Kalahari to get the real deal. There is certainly adequate motivation to figure out a cost effective process but if they had it in place they would have told the world when they had 60 Minutes' cameras attention. Maybe in a few years.... JR -----Original Message----- From: Dowling [mailto:christopher.a.dowling@...] Sent: Monday, November 22, 2004 7:38 AM Subject: Re: [ ] Re: Hoodia NOW Foods sells a hoodia containing supplement. They generally have a strong reputation for quality and I would be surprised if it did not contain what the labeling states. Perhaps there is just not enough hoodia in these supplements. On Mon, 22 Nov 2004 12:56:27 -0000, merlinspinnewin <joopes@...> wrote: > > > > > What about cultivating one's own hoodia crop? > > Very difficult, They rot very rapidly > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 22, 2004 Report Share Posted November 22, 2004 Hi folks: As someone once said, all a patent does is give you the right to sue anyone who violates it. And if you sue and win, all that does is give you the right to TRY to get the money out of the violator. It does NOT get you the money. In some cases the violator you have the judgment against simply declines to write the check. Then you have to try to find some other 'leverage' that will force them to pay up. Rodney. --- In , " Jeff Novick " <jnovick@p...> wrote: > Hoodia is an " old medicine " used by the Sans tribe in Africa to decrease appetite and enhance hydration. It is used on war marches or long hikes. A British > company, PhytoPharm PLC has isolated a saponon from hoodia, it is labeled P57. Pfizer bought the commercial rights for this " extraxT " and the patents from PhytoPharm PLC for ~$35 million. Studies in animals and humans demonstrate efficacy for appetite decrease and weight loss. Human studies have only been Phase I. Pfizer has decided not to develop it further and has reverted back the full rights to Phytopharm PLC for the product (and all of its patents). It appears that all of the companies who sell it as a dietary supplement are both in violation of the patnts and FDA law as related to filing for a New Dietary Ingredient > notification (similar to a GRAS filing with the FDA). Phytopharm is continuing to do clinical trials with P57 and just presented some data at NAASO last > week. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 22, 2004 Report Share Posted November 22, 2004 Hi folks: Based on the picture at this link it certainly looks like hoodia works ; ^ ))) http://news.bbc.co.uk/1/hi/programmes/correspondent/2947810.stm Rodney. > " 60 Minutes " ran a segment about this plant in the cactus family which > depresses appetite. Apparently no side effects. But won't be available in > any usable form til about 2008. > > What's now available is a rip-off with not enough hoodia to cause any > appetite suppression. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 22, 2004 Report Share Posted November 22, 2004 "It has no known side-effects, and contains a molecule that fools your brain into believing you are full. " Really? Tell it to Merck, and the makers of all the other appetite suppressants over the years. Notice it says no "known" side effects. That means none yet. Here's the one article in Medline: Brain Res. 2004 Sep 10;1020(1-2):1-11. Increased ATP content/production in the hypothalamus may be a signal for energy-sensing of satiety: studies of the anorectic mechanism of a plant steroidal glycoside.MacLean DB, Luo LG.Division of Endocrinology, Hallett Center for Diabetes and Endocrinology, Brown Medical School, Coro Building Providence, RI 02903, USA. david_b_maclean@...A steroidal glycoside with anorectic activity in animals, termed P57AS3 (P57), was isolated from Hoodia gordonii and found to have homologies to the steroidal core of cardiac glycosides. Intracerebroventricular (i.c.v.) injections of the purified P57AS3 demonstrated that the compound has a likely central (CNS) mechanism of action. There is no evidence of P57AS3 binding to or altering activity of known receptors or proteins, including Na/K-ATPase, the putative target of cardiac glycosides. The studies demonstrated that the compound increases the content of ATP by 50-150% in hypothalamic neurons. In addition, third ventricle (i.c.v.) administration of P57, which reduces subsequent 24-h food intake by 40-60%, also increases ATP content in hypothalamic slice punches removed at 24 h following the i.c.v. injections. In related studies, in pair fed rats fed a low calorie diet for 4 days, the content of ATP in the hypothalami of control i.c.v. injected animals fell by 30-50%, which was blocked by i.c.v. injections of P57AS3. With growing evidence of metabolic or nutrient-sensing by the hypothalamus, ATP may be a common currency of energy sensing, which in turn may trigger the appropriate neural, endocrine and appetitive responses as similar to other fundamental hypothalamic homeostatic centers for temperature and osmolarity.PMID: 15312781 Regards. ----- Original Message ----- From: Rodney Sent: Monday, November 22, 2004 10:03 AM Subject: [ ] Re: Hoodia Hi folks:Based on the picture at this link it certainly looks like hoodia works ; ^ )))http://news.bbc.co.uk/1/hi/programmes/correspondent/2947810.stmRodney. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 22, 2004 Report Share Posted November 22, 2004 I did use the NOW version, once. Seemed to work, but also made me slightly nauseous for a bit. On Mon, 22 Nov 2004 10:17:09 -0600, jwwright <jwwright@...> wrote: > > " It has > no known side-effects, and contains a molecule that fools your brain into > believing you are full. " > > Really? Tell it to Merck, and the makers of all the other appetite > suppressants over the years. > Notice it says no " known " side effects. That means none yet. > > Here's the one article in Medline: > > > Brain Res. 2004 Sep 10;1020(1-2):1-11. > Increased ATP content/production in the hypothalamus may be a signal for > energy-sensing of satiety: studies of the anorectic mechanism of a plant > steroidal glycoside. > > MacLean DB, Luo LG. > > Division of Endocrinology, Hallett Center for Diabetes and Endocrinology, > Brown Medical School, Coro Building Providence, RI 02903, USA. > david_b_maclean@... > > A steroidal glycoside with anorectic activity in animals, termed P57AS3 > (P57), was isolated from Hoodia gordonii and found to have homologies to the > steroidal core of cardiac glycosides. Intracerebroventricular (i.c.v.) > injections of the purified P57AS3 demonstrated that the compound has a > likely central (CNS) mechanism of action. There is no evidence of P57AS3 > binding to or altering activity of known receptors or proteins, including > Na/K-ATPase, the putative target of cardiac glycosides. The studies > demonstrated that the compound increases the content of ATP by 50-150% in > hypothalamic neurons. In addition, third ventricle (i.c.v.) administration > of P57, which reduces subsequent 24-h food intake by 40-60%, also increases > ATP content in hypothalamic slice punches removed at 24 h following the > i.c.v. injections. In related studies, in pair fed rats fed a low calorie > diet for 4 days, the content of ATP in the hypothalami of control i.c.v. > injected animals fell by 30-50%, which was blocked by i.c.v. injections of > P57AS3. With growing evidence of metabolic or nutrient-sensing by the > hypothalamus, ATP may be a common currency of energy sensing, which in turn > may trigger the appropriate neural, endocrine and appetitive responses as > similar to other fundamental hypothalamic homeostatic centers for > temperature and osmolarity. > > PMID: 15312781 > Regards. > > > > > ----- Original Message ----- > From: Rodney > > Sent: Monday, November 22, 2004 10:03 AM > Subject: [ ] Re: Hoodia > > > Hi folks: > > Based on the picture at this link it certainly looks like hoodia > works ; ^ ))) > > http://news.bbc.co.uk/1/hi/programmes/correspondent/2947810.stm > > Rodney. > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 22, 2004 Report Share Posted November 22, 2004 Hi folks: It seems to me that, in addition to the possible dangers inherent in consuming 'new substances', caloric restriction wouldn't be half as satisfying to achieve if it was dead easy. (I believe the natives in the Andes use coca for the same purpose - to suppress hunger). Rodney. > > > > " It has > > no known side-effects, and contains a molecule that fools your brain into > > believing you are full. " > > > > Really? Tell it to Merck, and the makers of all the other appetite > > suppressants over the years. > > Notice it says no " known " side effects. That means none yet. > > > > Here's the one article in Medline: > > > > > > Brain Res. 2004 Sep 10;1020(1-2):1-11. > > Increased ATP content/production in the hypothalamus may be a signal for > > energy-sensing of satiety: studies of the anorectic mechanism of a plant > > steroidal glycoside. > > > > MacLean DB, Luo LG. > > > > Division of Endocrinology, Hallett Center for Diabetes and Endocrinology, > > Brown Medical School, Coro Building Providence, RI 02903, USA. > > david_b_maclean@b... > > > > A steroidal glycoside with anorectic activity in animals, termed P57AS3 > > (P57), was isolated from Hoodia gordonii and found to have homologies to the > > steroidal core of cardiac glycosides. Intracerebroventricular (i.c.v.) > > injections of the purified P57AS3 demonstrated that the compound has a > > likely central (CNS) mechanism of action. There is no evidence of P57AS3 > > binding to or altering activity of known receptors or proteins, including > > Na/K-ATPase, the putative target of cardiac glycosides. The studies > > demonstrated that the compound increases the content of ATP by 50- 150% in > > hypothalamic neurons. In addition, third ventricle (i.c.v.) administration > > of P57, which reduces subsequent 24-h food intake by 40-60%, also increases > > ATP content in hypothalamic slice punches removed at 24 h following the > > i.c.v. injections. In related studies, in pair fed rats fed a low calorie > > diet for 4 days, the content of ATP in the hypothalami of control i.c.v. > > injected animals fell by 30-50%, which was blocked by i.c.v. injections of > > P57AS3. With growing evidence of metabolic or nutrient-sensing by the > > hypothalamus, ATP may be a common currency of energy sensing, which in turn > > may trigger the appropriate neural, endocrine and appetitive responses as > > similar to other fundamental hypothalamic homeostatic centers for > > temperature and osmolarity. > > > > PMID: 15312781 > > Regards. > > > > > > > > > > ----- Original Message ----- > > From: Rodney > > > > Sent: Monday, November 22, 2004 10:03 AM > > Subject: [ ] Re: Hoodia > > > > > > Hi folks: > > > > Based on the picture at this link it certainly looks like hoodia > > works ; ^ ))) > > > > http://news.bbc.co.uk/1/hi/programmes/correspondent/2947810.stm > > > > Rodney. > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 22, 2004 Report Share Posted November 22, 2004 Rodney's link below is a good overview of what was said on the " 60 minutes " segment. Lesley Stahl who was reporting, ate some and had no immediate side effects such as nausea (or at least that's what was reported in the segment). According to Rod's link below there's also a " feel good " feeling associated with it (sounds good to me :-). What a great plant if indeed it delivers all that it promises. OTOH, I can see the potential for abuse by anorexics and those who would prize the aphrodisiac side of it. And due to the difficulty of growing it, it will probably be expensive. on 11/22/2004 11:03 AM, Rodney at perspect1111@... wrote: > > Hi folks: > > Based on the picture at this link it certainly looks like hoodia > works ; ^ ))) > > http://news.bbc.co.uk/1/hi/programmes/correspondent/2947810.stm > > Rodney. > Quote Link to comment Share on other sites More sharing options...
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