Re: Biomarkers of CR in Mice and Monkeys Correlate with Human Longevity

[Guest guest]

> Here is an interesting article summarizing a 2002 paper

> concluding that CR biomarkers in Mice and Monkeys

> correlate positively with human longevity (which

> is reassuring but not conclusive). The human subjects

> themselves were not on CR -- but having good CR biomarkers

> was indicative of predicting a longer life.

>

> http://www.longenity.com/aug02.html

>

> -------------------------------------------------

> Here is another article that mentions morphological CR factors

> (leanness, absence of body fat, low insulin) correlated positively

> with longevity. It specifically mentions Dr. Fuhrman's

> dietary strategy, visible when clicking the Fuhrman link.

>

> http://www.fact-index.com/c/ca/caloric_restriction.html

>

> ------------------------------------------------------

> This is the article of chief interest:

>

> Biomarkers of Caloric Restriction May Predict Longevity in Humans;

> S. Roth, Mark A. Lane, K. Ingram, A. Mattison,

> Dariush Elahi, Jordan D. Tobin, Denis Muller, and E. Metter

> Science Aug 2 2002: 811

>

> Of the 3 biomarkers, (DHEAS, temperature, insulin), low levels of

> DHEAS (which is related to low testosterone levels) showed the

> most remarkable and distinct predictive correlation with longevity.

>

> See table: http://www.sciencemag.org/cgi/data/297/5582/811/DC1/1

>

> Between 8 to 10 years extra life was gained for all death

percentiles,

> just by belonging to the half of the group with lowest DHEAS levels.

> This clearly says for non-CR men: Keep your sex hormone levels

low,

> if you want to live a longer life. For CR men, low levels happen

> automatically and involuntarily -- as a feature of the CR diet.

Hi All,

I believe that the important message would be that " CR attenuated the

age-associated decline in both dehydroepiandrosterone (DHEA) ...in

males. ... PMID: 12543259 [PubMed - indexed for MEDLINE]

Cheers, Al Pater.