Biomarkers of CR in Mice and Monkeys Correlate with Human Longevity

[Guest guest]

Here is an interesting article summarizing a 2002 paper

concluding that CR biomarkers in Mice and Monkeys

correlate positively with human longevity (which

is reassuring but not conclusive). The human subjects

themselves were not on CR -- but having good CR biomarkers

was indicative of predicting a longer life.

http://www.longenity.com/aug02.html

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Here is another article that mentions morphological CR factors

(leanness, absence of body fat, low insulin) correlated positively

with longevity. It specifically mentions Dr. Fuhrman's

dietary strategy, visible when clicking the Fuhrman link.

http://www.fact-index.com/c/ca/caloric_restriction.html

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This is the article of chief interest:

Biomarkers of Caloric Restriction May Predict Longevity in Humans;

S. Roth, Mark A. Lane, K. Ingram, A. Mattison,

Dariush Elahi, Jordan D. Tobin, Denis Muller, and E. Metter

Science Aug 2 2002: 811

Of the 3 biomarkers, (DHEAS, temperature, insulin), low levels of

DHEAS (which is related to low testosterone levels) showed the

most remarkable and distinct predictive correlation with longevity.

See table: http://www.sciencemag.org/cgi/data/297/5582/811/DC1/1

Between 8 to 10 years extra life was gained for all death percentiles,

just by belonging to the half of the group with lowest DHEAS levels.

This clearly says for non-CR men: Keep your sex hormone levels low,

if you want to live a longer life. For CR men, low levels happen

automatically and involuntarily -- as a feature of the CR diet.

-- Warren