Spindler Article - Courtesy Warren

[Guest guest]

Hi folks:

[ I see I repeated the same link twice back there! Sorry. Now I

can't find the second link I had meant to post : ^ ((( ]

The Spindler article is interesting in a number of respects. There

is no mention in the article of supplementing the CR mice. So I

assume they were just simply fed a lot less of the identical food.

If so, then it may be telling us something.

Second, these older CR mice had a 70% reduction in mortality compared

with the controls. BUT THE CONTROLS WERE ON 10% CR!!! So the

reduction in mortality would be greater if compared with ad lib mice.

These data are quite similar to the data from fruit flies, which also

were not supplemented. One difference is that in this mouse study CR

was introduced gradually, in two stages. In the case of the fruit

flies 40% CR was implemented immediately.

The article suggests that 19 month old mice are the equivalent of 60

to 65 year old humans. I guess we should take their word for that.

But if 100 years in humans is about equivalent to 40 months in a

mouse's life, then by my calculations a 19 month mouse is more like

50 human years. (Perhaps these calculations need to be more

complicated however).

VERY interesting, and encouraging, stuff.

Thanks Warren!

Rodney.