Various causes of ES symptoms

[Guest guest]

Besides the leaky cell membrane, other biological effects found under research

are given at http://www.wireless-precaution.com/main/science.php. These include

DNA breaks, increased free radical activity, calcium efflux affecting the brain

and heart, increased production of histamines, blood cell clumping, and more.

This might give you some suggestions such as increasing levels of antioxidants,

getting adequate magnesium to balance calcium, etc.

http://www.wireless-precaution.com/main/nutrition.php

>

> > I just listened to the talk by Dr. Goldsworthy about leaky cell

membranes being the cause of ES symptoms. Can't say I understood all of it

(brain-fog and all) but my question is this -- if that is the cause of all this

misery, how do we fix the cell membranes so they don't leak???

>

> I doubt that his theory about leaky cell membranes applies to EVERYONE on this

list. I think there are various causes of ES, and you need to figure out which

one applies to you. For example, I'm fairly certain that my ES is merely a side

effect of mercury poisoning. While someone else may be suffering from a vitamin

deficiency, someone else has a parasite problem, and someone else has leaky cell

membranes. And many people here probably have a combination of several things

going on.

>

> Marc

>

[Guest guest]

Hi, Emraware,

 

You write:

Besides the leaky cell membrane, other biological effects found under research

are given at http://www.wireless-precaution.com/main/science.php. These include

DNA breaks, increased free radical activity, calcium efflux affecting the brain

and heart, increased production of histamines, blood cell clumping, and more.

 

I reply:

Leaky cell membrane (tight junction permeability), however, is much more than an

effect in ES (as well as the dozen or more illnesses people with ES are also

likely to have).  It is an affect.  And most of the other symptoms you list

are also caused by tj permeability or are secondary to problems directly caused

by it.  And tj permeability, itself, is a genetic condition.  Calcium efflux

is directly caused by tj permeability in both the brain and the heart. The

other problems you mention are secondary to other problems caused by tj

permeability. I am not able to be online very long any more due to " real life " ,

however, in a short amount of time last night, I was able to find these excerpts

just by googling the words " tight junction permeability " :

" In a relatively short time, our knowledge of the tight junction has evolved

from a relatively simple view of it being a permeability barrier in the

paracellular space and a fence in the plane of the plasma membrane to one of it

acting as a multicomponent, multifunctional complex that is involved in

regulating numerous and diverse cell functions. A group of integral membrane

proteins—occludin, claudins, and junction adhesion molecules—interact with

an increasingly complex array of tight junction plaque proteins not only to

regulate paracellular solute and water flux but also to integrate such diverse

processes as gene transcription, tumor suppression, cell proliferation, and cell

polarity. " (found at:)

http://ajpcell.physiology.org/content/286/6/C1213.full

" Tight junctions are heteromeric protein complexes that act as signaling centers

by mediating the bidirectional transmission of information between the

environment and the cell interior to control paracellular permeability and

differentiation. Insight into tight junction-associated signaling mechanisms is

of fundamental importance for our understanding of the physiology of epithelia

and endothelia in health and disease.

In multicellular organisms, epithelia consist of specialized cells that form

selective barriers controlling the passage of water, ions, and other small

molecules between different body compartments and the external environment. This

requires cells to be polarized, that is, to form distinct membrane domains: an

apical side, facing the lumen of a body cavity or the outside environment, and a

basal side, adjacent to the underlying tissue. For instance, the epithelial

cells lining the intestinal lumen are at the interface between the internal and

external environments, regulating the absorption of nutrients and water, as well

as ion homeostasis. In addition, these cells provide a protective barrier

against commensal and pathogenic microorganisms. " (found at:)

http://physiologyonline.physiology.org/content/25/1/16.full

I have been following this area of medical research since 2000, when Dr. Alessio

Fasano and his team of researchers discovered zonulin and zot are increased in

those with celiac disease [which I have], and that these (zonuline and

zot)breach the gut and bbb tight junction barriers [it is now know they breach

many organs]. By 2004, I learned particular emfs also breach the tight

junctions. By 2006, I learned tj permeability was genetic, leading to increased

permeability in about 22 to 24% of the population. At that time, I had to

wonder whether those of us with ES (and other diseases such as FM, CFS, MCS, MS,

dysautonomia (ANSD), besides celiac disease, are all among those with this tj

permeability genetic profile and I mentioned this at this forum around that time

or possibly a bit later. For one thing--this would allow for why the cell phone

industry was able to find NO side effects caused by cell phone use. [They

cherry pick test subjects who are

normal (no cfs, no fms, no mcs, no....) instead of people with these diseases!

They clearly state that they have done this on their studies.] Since that time,

some researchers are making findings that are consistent with my thoughts that

all these " new " diseases are infact linked. They are all thought to be

" ion-channelopathy " diseases now. Celiac disease was known to be an

ion-channelopathy since 2000.

Since that time, (finding other diseases ion-channel linked) doctors such as

Goldsworthy have jumped on the bandwagon. There is continuing research every

year that encourages me that this is not a dead-end. Marc mentions metal

hoarding--esp mercury hoarding as a cause of ES. He is right, it is a cause!

Mercury hoarding is also caused/ made harder to detox by tj permeability! There

are research studies out there which show this, however, I sent dozens of these

studies last year, and only a few people here were interested. And I didn't

send the studies as I found them before that--with the subjects of what they

showed, because before that *nobody* was interested. It was like Diane's

latest, greatest adventure and nobody thought I was correct.

Unfortunately, since 2009, I no longer have the time to sift thru these studies

and share them like I once could have. I am taking care of my elderly parents,

an alzheimers father, and 3 houses. My time is now tied up in real life. Lucky

I got enough info from the studies myself to at least help me! I have overcome

cfs, fms, osteoporosis, (and more) and can well control my ANSD, diabetes, liver

disease, chronic bronchial asthma, ES, and CD, so far. MCS has been the only

one which has stayed very resistent. That and hand tremors still plague me. I

assume that hand tremors are toxin related or from lack of a particular enzyme

needed, which is GABA related. (GABA is something I cannot tolerate well, as it

leaks into the bbb too readily, from tj permeability.)

The answers are out there to find if you search for them. But it takes work and

time. We are all different, that is true; but we are also very much the same.

The sources are there. Ask and you shall find. Do I know it all? Of course

not; not even close to a millionth of 1 percent. But I know what I need to know

as I continue to search and ask. I don't close my mind to any doors. If you do

that, you will never find.

My quarter's worth,

Diane

From: emraware <emraware@...>

Subject: Various causes of ES symptoms

Date: Tuesday, May 31, 2011, 8:48 PM

 

This might give you some suggestions such as increasing levels of antioxidants,

getting adequate magnesium to balance calcium, etc.

http://www.wireless-precaution.com/main/nutrition.php

>

> > I just listened to the talk by Dr. Goldsworthy about leaky cell

membranes being the cause of ES symptoms. Can't say I understood all of it

(brain-fog and all) but my question is this -- if that is the cause of all this

misery, how do we fix the cell membranes so they don't leak???

>

> I doubt that his theory about leaky cell membranes applies to EVERYONE on this

list. I think there are various causes of

ES, and you need to figure out which one applies to you. For example, I'm

fairly certain that my ES is merely a side effect of mercury poisoning. While

someone else may be suffering from a vitamin deficiency, someone else has a

parasite problem, and someone else has leaky cell membranes. And many people

here probably have a combination of several things going on.

>

> Marc

>

[Guest guest]

Evie, do you know if there are any treatments (including " alternative medicine " )

that have helped alleviate symptoms of high tj permeability?

-E. Drew

From: emraware <emraware@...>

Subject: Various causes of ES symptoms

Date: Tuesday, May 31, 2011, 8:48 PM

 

This might give you some suggestions such as increasing levels of antioxidants,

getting adequate magnesium to balance calcium, etc.

http://www.wireless-precaution.com/main/nutrition.php

>

> > I just listened to the talk by Dr. Goldsworthy about leaky cell

membranes being the cause of ES symptoms. Can't say I understood all of it

(brain-fog and all) but my question is this -- if that is the cause of all this

misery, how do we fix the cell membranes so they don't leak???

>

> I doubt that his theory about leaky cell membranes applies to EVERYONE on this

list. I think there are various causes of

ES, and you need to figure out which one applies to you. For example, I'm

fairly certain that my ES is merely a side effect of mercury poisoning. While

someone else may be suffering from a vitamin deficiency, someone else has a

parasite problem, and someone else has leaky cell membranes. And many people

here probably have a combination of several things going on.

>

> Marc

>

[Guest guest]

Hi Elysia,

 

Read the second post I just wrote Amy.  I just answered this awhile ago.

 

Also consider raising your pH--I wrote alot about that last week.  That is a

problem which would likely be universal. Take supplements to feed your liver

detox function.  We all have plenty to detox, due to the tight junction

permeability.  Also, compare the email about " bluegreen's " girlfriend's

treatments with my recent email (I think yesterday) to newbies.  You will see

we do a number of things in common.  Unfortunately, unless you are one of my

clones, j/k, my supplement therapy would likely not work for you.  I have met

a person here who is a clone almost, of me.  She is going to try

the supplements I take, but she is yet having to deal with problems I fixed

years before starting the tj supplement mix. 

 

This is another thing--you have to do things in a specific order.  If you

haven't dealt with your liver, you cannot detox successfully.  You also need to

feed your adrenals and lymphatics to detox.  You also need to clean out the

pores of your skin in order to detox.  (With epsom salts, sea salts, baking

soda, clays, etc--used separately--usually as soaking baths.)  You may need to

support your kidneys to detox.  If you do not detox, you are likely not to get

alot out of treating pH.  You need to treat gut flora if that is a problem, and

gluten, if that is a problem....  Each of these will hold back other attempts

at treatment.  Estrogen and serotonin problems need worked out.....  So, make

a list of your problem areas (mine was very long), and then try to find a way

to prioritize them.  I messed up multiple times.  You will goof too.  This is

okay.  This is not a 2 week program, no matter what some others say.  It is a

2+ year

commitment.  For some it will be much longer.  And i am not talking cure

here, I am talking major improvement.  And you will have to be determined to

get there. 

 

Good luck Elysia and bless you,

Diane

From: emraware <emraware@...>

Subject: Various causes of ES symptoms

Date: Tuesday, May 31, 2011, 8:48 PM

 

This might give you some suggestions such as increasing levels of antioxidants,

getting adequate magnesium to balance calcium, etc.

http://www.wireless-precaution.com/main/nutrition.php

>

> > I just listened to the talk by Dr. Goldsworthy about leaky cell

membranes being the cause of ES symptoms. Can't say I understood all of it

(brain-fog and all) but my question is this -- if that is the cause of all this

misery, how do we fix the cell membranes so they don't leak???

>

> I doubt that his theory about leaky cell membranes applies to EVERYONE on this

list. I think there are various causes of

ES, and you need to figure out which one applies to you. For example, I'm fairly

certain that my ES is merely a side effect of mercury poisoning. While someone

else may be suffering from a vitamin deficiency, someone else has a parasite

problem, and someone else has leaky cell membranes. And many people here

probably have a combination of several things going on.

>

> Marc

>