Question

[Guest guest]

vascular endothelial growth factor (VEGF). They promote the growth of blood

vessels in solid tumours.

It is known that the malignant cells secrete VEGF and possess VEGF receptors.

This suggests that an autocrine loop might be important in the pathogenesis of

CLL.

VEGF is a sub-family of growth factors, specifically the platelet-derived growth

factor family of cystine-knot growth factors. The serum levels of VEGF and

VEGFR-2, but not VEGFR-1, are significantly higher in more advanced CLL

patients, and may have an important influence on the course of B-CLL.

VEGF levels can be measured but there are no clinical tests for VEGF. There is

evidence that the CLL cells themselves may be an important source of VEGF. On

the other hand, it is known that VEGF is produced by many normal tissues eg

macrophages, fibroblasts, enothelial cells.

It may play a role in CLL cell appoptosis. There are a number of recombinant,

fully human monoclonal antibody directed against human vascular endothelial

growth factor receptor 2 (VEGFR-2) with antiangiogenesis activity, like

ramucirumab, ranibizumab, vandetanib, motesanib, and axitinib etc.

Further reading here:

http://en.wikipedia.org/wiki/Vascular_endothelial_growth_factor

http://theoncologist.alphamedpress.org/cgi/content/full/6/suppl_5/32

http://www.nature.com/leu/journal/v19/n8/full/2403837a.html

http://www.nature.com/leu/journal/v19/n4/abs/2403667a.html

This is a hugely complicated field under extensive research...

HTH

~chris

>

> Does anyone have any knowledge about how vital a role VEGF plays in

> cll/sll? Should we be tested for it? Can it be combatted?

> Thanks,

> Ellen R.

>

[Guest guest]

Vascular endothelial growth factor (VEGF) is a remarkably interesting molecule

that has been a focus of particular interest for me. VEGF is a cytokine, which

is a chemical secreted by cells that is intended to act upon cells in the local

environment of those cells. VEGF was originally identified in the 1990s and was

thought to be primarily responsible for new blood vessel growth.

VEGF is now known to have many activities far beyond blood vessel growth. CLL

cells have receptors for VEGF and their survival is enhanced by VEGF. My

investigators have demonstrated that VEGF levels, as well as some surrogate

markers, are prognostic in CLL patients, with high levels indicating a poorer

prognosis.

I believe VEGF and its related cytokines (including bFGF) are better thought of

as " angiogenic factors " . Angiogenic means new blood vessel growth, but in CLL,

blood vessel growth likely plays no role as the cells live in the blood.

What is also of interest is that thalidomide is thought to act through many

different mechanisms, but one of the most important is by inhibiting VEGF

signaling. Since we know thalidomide has activity in CLL, this might be

evidence of VEGF's importance.

There are several trials studying inhibition of VEGF in CLL. Some are using

Avastin, which is an antibody to VEGF, and some other molecules that inhibit the

pathway.

Rick Furman, MD

>

> Does anyone have any knowledge about how vital a role VEGF plays in

> cll/sll? Should we be tested for it? Can it be combatted?

> Thanks,

> Ellen R.

>

[Guest guest]

When SLL/CLL recurs 12 months after FCR Rx and presents with symptoms and biopsy proven transformation within marrow and nodes what has happened and is RCHOP Rx adequate? Is allogenic stem/bone marrow transplant indicated and what type ie non ablative or ablative? What questions should be asked about prognostic markers? How does one select a transplant center and protocol?

Thanks

Re: question

Vascular endothelial growth factor (VEGF) is a remarkably interesting molecule that has been a focus of particular interest for me. VEGF is a cytokine, which is a chemical secreted by cells that is intended to act upon cells in the local environment of those cells. VEGF was originally identified in the 1990s and was thought to be primarily responsible for new blood vessel growth.VEGF is now known to have many activities far beyond blood vessel growth. CLL cells have receptors for VEGF and their survival is enhanced by VEGF. My investigators have demonstrated that VEGF levels, as well as some surrogate markers, are prognostic in CLL patients, with high levels indicating a poorer prognosis.I believe VEGF and its related cytokines (including bFGF) are better thought of as "angiogenic factors". Angiogenic means new blood vessel growth, but in CLL, blood vessel growth likely plays no role as the cells live in the blood.What is also of interest is that thalidomide is thought to act through many different mechanisms, but one of the most important is by inhibiting VEGF signaling. Since we know thalidomide has activity in CLL, this might be evidence of VEGF's importance.There are several trials studying inhibition of VEGF in CLL. Some are using Avastin, which is an antibody to VEGF, and some other molecules that inhibit the pathway. Rick Furman, MD>> Does anyone have any knowledge about how vital a role VEGF plays in> cll/sll? Should we be tested for it? Can it be combatted?> Thanks,> Ellen R.>

[Guest guest]

,

It sounds as if you have had a Richter's transformation. Much information is

available at the CIG site regarding this. A Richter's transformation occurs

when CLL transforms into a diffuse large B cell lymphoma. R-CHOP is typically

the first line treatment. Many people require follow-up therapy followed by an

autologous stem cell transplantation. Allogeneic transplants would still be

considered experimental. How the tissue looks and seeing the response to the

first therapy are both important predictors of howing things will go and should

be used to guide therapy.

Rick Furman, MD

> >

> > Does anyone have any knowledge about how vital a role VEGF plays in

> > cll / sll ? Should we be tested for it? Can it be combatted ?

> > Thanks,

> > Ellen R.

> >

>

>

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[Guest guest]

Dr. Furman, are you saying that there IS a test for VEGF levels?

A blood test?

Thanks,

Ellen R.

rrfman wrote:

Vascular endothelial growth factor (VEGF) is a remarkably

interesting molecule that has been a focus of particular interest for me.

VEGF is a cytokine, which is a chemical secreted by cells that is intended

to act upon cells in the local environment of those cells. VEGF was originally

identified in the 1990s and was thought to be primarily responsible for

new blood vessel growth.

VEGF is now known to have many activities far beyond blood vessel growth.

CLL cells have receptors for VEGF and their survival is enhanced by VEGF.

My investigators have demonstrated that VEGF levels, as well as some surrogate

markers, are prognostic in CLL patients, with high levels indicating a

poorer prognosis.

I believe VEGF and its related cytokines (including bFGF) are better

thought of as "angiogenic factors". Angiogenic means new blood vessel growth,

but in CLL, blood vessel growth likely plays no role as the cells live

in the blood.

What is also of interest is that thalidomide is thought to act through

many different mechanisms, but one of the most important is by inhibiting

VEGF signaling. Since we know thalidomide has activity in CLL, this might

be evidence of VEGF's importance.

There are several trials studying inhibition of VEGF in CLL. Some are

using Avastin, which is an antibody to VEGF, and some other molecules that

inhibit the pathway.

Rick Furman, MD

[Guest guest]

Yes, VEGF levels are commercially available. A caveat that I believe in

regarding testing of cytokines is that these molecules are meant to act over

very small distances (between two cells). It is unclear whether the measuring

of them in the blood is reflective of what is occurring at the cellular level.

Thus, while our data is generated from measuring blood levels, there are likely

to be many other factors impacting upon the cell interactions. An example would

be patients with low VEGF levels still may respond to VEGF inhibitors.

Rick Furman, MD

>

> >

> > Vascular endothelial growth factor (VEGF) is a remarkably interesting

> > molecule that has been a focus of particular interest for me. VEGF is

> > a cytokine, which is a chemical secreted by cells that is intended to

> > act upon cells in the local environment of those cells. VEGF was

> > originally identified in the 1990s and was thought to be primarily

> > responsible for new blood vessel growth.

> >

> > VEGF is now known to have many activities far beyond blood vessel

> > growth. CLL cells have receptors for VEGF and their survival is

> > enhanced by VEGF. My investigators have demonstrated that VEGF levels,

> > as well as some surrogate markers, are prognostic in CLL patients,

> > with high levels indicating a poorer prognosis.

> >

> > I believe VEGF and its related cytokines (including bFGF) are better

> > thought of as " angiogenic factors " . Angiogenic means new blood vessel

> > growth, but in CLL, blood vessel growth likely plays no role as the

> > cells live in the blood.

> >

> > What is also of interest is that thalidomide is thought to act through

> > many different mechanisms, but one of the most important is by

> > inhibiting VEGF signaling. Since we know thalidomide has activity in

> > CLL, this might be evidence of VEGF's importance.

> >

> > There are several trials studying inhibition of VEGF in CLL. Some are

> > using Avastin, which is an antibody to VEGF, and some other molecules

> > that inhibit the pathway.

> >

> > Rick Furman, MD

> >

>

[Guest guest]

Try this resource for locating and evaluating centers, but also ask your

oncologist of course. http://www.bmtinfonet.org/transplantcenters

> >

> > Does anyone have any knowledge about how vital a role VEGF plays in

> > cll / sll ? Should we be tested for it? Can it be combatted ?

> > Thanks,

> > Ellen R.

> >

>

>

> __ ._,_. __ _

>

> Reply to sender | Reply to group | Reply via web post | Start a New Topic

Messages in this topic ( 44 )

> Recent Activity:

>

> • New Members 6

>

>

> Visit Your Group

>

> Switch to: Text-Only , Daily Digest • Unsubscribe • Terms of Use

>

>

> .

>

> __ ,_._, __ _

>

[Guest guest]

, you might try Ray Peat's Progest-E. He discovered that one absorbs 100%

of the progesterone when it is in vitamin E. It is applied to the gums.

Joan

>

>

>

>

> <010001c6d0de$7e8684e0$6401a8c0>

>

>

> Since I began the Iodine, I've had some menstrual dysregulation that is

off the wall. I've had two periods within 7 days of eachother which never

happens, and they have been MUCH heavier and crampier than usual, and I have

been passing more large clots than I can count. I couldn't help but wonder if

the iodine supplementation has something to do with this, in that maybe it is

working through trying to regulate my hormones and my uterus is responding by

all this excess shedding...

>

> Any ideas?

>

>

>

> .

>

[Guest guest]

I had this same thing happen. It wasn't until I went to 400mg of oral P that

the bleeding stopped. Once I stopped the break through bleeding, I would have

10 day or more cycles. Now, I'm not having any bleeding at all even on a lower

dose of P. It's very frustrating, but I'd rather have none for a while than one

every 10 days or having one that lasted 22 days. Yes, that happened.

I think it just takes some time and tweaking of everything to get it right.

> >

> >

> >

> >

> > <010001c6d0de$7e8684e0$6401a8c0>

> >

> >

> > Since I began the Iodine, I've had some menstrual dysregulation that is

off the wall. I've had two periods within 7 days of eachother which never

happens, and they have been MUCH heavier and crampier than usual, and I have

been passing more large clots than I can count. I couldn't help but wonder if

the iodine supplementation has something to do with this, in that maybe it is

working through trying to regulate my hormones and my uterus is responding by

all this excess shedding...

> >

> > Any ideas?

> >

> >

> >

> > .

> >

>

[Guest guest]

Hi,

Crackling, sizzling sounds might indicate you are on TELECOIL and not

know it. If you are near your computer, your refrigerator, or

fluorescent lights you will pick up static sounds when on telecoil. Same

if you are near a light switch with a dimmer. So check and make sure

you are not on telecoil. If you have a Freedom, it will show T along

with M setting on the screen. If you are on a Nucleus 5, just stand

under a fluorescent light. If it crckles and makes those noises, hold

down the higher of the 2 switches. That is what engages and disengages

the telecoil. Or you can use your remote and see if you're on telecoil.

Hi guys,

I noticed that after my recent mapping, my processors (both) are making

crackling/sizzling sounds once I turn it on. It goes away. That never

happened before. And sometimes I get that crackling off and on, too.

I changed batteries. I switched to disposables, but they still " buzzed "

like electric interference. So I'm concerend it's the processor or (oh

no) the implant.

____________________________________________________________

Penny Stock Jumping 2000%

Sign up to the #1 voted penny stock newsletter for free today!

http://thirdpartyoffers.juno.com/TGL3141/4be2127f5ca4e3442fcst03duc

[Guest guest]

In a message dated 5/10/2010 7:44:44 PM Eastern Daylight Time, amoslarkinsii@... writes:

you mean no one can help me find out how long i've been associated with this group? not even the sota people who run this website?

Sota does not run this group. I founded the group in March 24, 1999 and have no affiliation with any of the vendors who share helpful information and encouragement to new members.

You joined the group September 19, 2006. You can view your own information by going to the group homepage:

You must use your password that you used when you joined the group.

Dotsie

[Guest guest]

thanks dotsie:

From: "DotsieBoo@..." <DotsieBoo@...> Sent: Mon, May 10, 2010 7:57:00 PMSubject: Re: QUESTION

In a message dated 5/10/2010 7:44:44 PM Eastern Daylight Time, amoslarkinsii writes:

you mean no one can help me find out how long i've been associated with this group? not even the sota people who run this website?Sota does not run this group. I founded the group in March 24, 1999 and have no affiliation with any of the vendors who share helpful information and encouragement to new members.You joined the group September 19, 2006. You can view your own information by going to the group homepage:Beck-blood-electrif ication@gro ups.com You must use your password that you used when you joined the group.Dotsie

[Guest guest]

Why don't you go back to the first posts on this site and see where you posted

first. It'll give you an approximation anyway. When I joined, I did this just to

fill myself in on what people were saying.

Dick

>

> you mean no one can help me find out how long i've been associated with this

group? not even the sota people who run this website?

>

[Guest guest]

Fractionated coconut oil is another name for MCT oil. The oil is made by

separating out each of fatty acids in the coconut oil and then recombining a

select few, usually just two. It is not hydrogenated.

Bruce

From: Coconut Oil

[mailto:Coconut Oil ] On Behalf Of Evie

Sent: Saturday, May 15, 2010 2:12 PM

Coconut Oil

Subject: Question

What is 'Fractionated or fractured coconut oil' is that another way of

saying that it is hydorgenated ?

[Guest guest]

Commercially, they call it Capric/Caprylic Triglyceride (correct me if I'm wrong

Bruce). We use it as additive for our skin care products to reduce the thickness

of the VCO.

Archie

From: Bruce Fife <bruce@...>

Subject: RE: Question

Coconut Oil

Date: Monday, 17 May, 2010, 10:32 PM

 

Fractionated coconut oil is another name for MCT oil. The oil is made by

separating out each of fatty acids in the coconut oil and then recombining a

select few, usually just two. It is not hydrogenated.

Bruce

From: Coconut Oil

[mailto:Coconut Oil ] On Behalf Of Evie

Sent: Saturday, May 15, 2010 2:12 PM

Coconut Oil

Subject: Question

What is 'Fractionated or fractured coconut oil' is that another way of

saying that it is hydorgenated ?

[Guest guest]

It¹s early days, . I¹m told by doc and sister (TKR 4 + years ago) that

I can expect some pain 12-18 months out.

I continue to have pain after exercising and also when I¹ve been to

stationary. Ice and elevation, OTC anti-inflammatories and OTC pain meds,

massage, acupuncture, etc, do help. I just wish I¹d get on it right after

exercising. I think if I iced after exercise each time I¹d be a lot more

comfortable.

I have a cranky left knee yesterday this morning; finally iced this am and

did some massage and it feels better.

Jackie

--

Jackie on

Jackiett@...

R-TKR 3-19-09

L-TKR 9-1-09

Dr. Patch

On 5/19/10 12:45 PM, " Banks " <lindabandcompany@...> wrote:

>

>

>

>

>

>

>

> I had my tkr, April 14th and everything has been going great.  Well yesterday

> my knee was very sore and today also?????  Has anyone else had this problem

> and if so what did you do about it?  Thanks,

>

>

[Guest guest]

,

Are you keeping up with your meds.? And as I just said, I iced and elevate and

then move.

Donna R

question

I had my tkr, April 14th and everything has been going great.� Well yesterday

my knee was very sore and today also?????� Has anyone else had this problem

and if so what did you do about it?� Thanks,

[Guest guest]

Thanks Jackie.  My right knee will be replaced probably in Sept but that darn

thing is giving me trouble now, it hurts when I do the stand up exercises for my

left knee???  Oh joy joy!!!! NOT!!

>

>

>

>

>

>

>

> I had my tkr, April 14th and everything has been going great.  Well yesterday

> my knee was very sore and today also?????  Has anyone else had this problem

> and if so what did you do about it?  Thanks,

>

>

[Guest guest]

My os told me to stop icing????? 

From: Donna Rae <rae900@...>

Subject: Re: question

Joint Replacement

Date: Wednesday, May 19, 2010, 2:55 PM

 

,

Are you keeping up with your meds.? And as I just said, I iced and elevate and

then move.

Donna R

question

I had my tkr, April 14th and everything has been going great.� Well

yesterday my knee was very sore and today also?????� Has anyone else had

this problem and if so what did you do about it?� Thanks,

[Guest guest]

My PT iced every time I went and encouraged me to keep doing it even after PT

was done. It sure took my swelling down and sometimes when I can sleep, I ice

and elevate with my pain pills. And it allows me to sleep.

Donna R

question

I had my tkr, April 14th and everything has been going great.� Well

yesterday my knee was very sore and today also?????� Has anyone else had

this problem and if so what did you do about it?� Thanks,

[Guest guest]

Hi ,

That doesn¹t sound right.

Not sure what exactly s/he said....Was it on the order of that you should

not ice anymore? Or that icing was no longer required as it was right after

your surgery? If the former, Was there a problem s/he was addressing by

telling you not to ice?

I know it can be problematic if we ice for too long or too often but never

heard that there was a time when we should stop.

Jackie

Did he say why to stop icing? To stop altogether? Or just that you didn¹t

need to continue in the same way?

J

>

> Re: question

>

> My os told me to stop icing????? 

>

>

>

>

[Guest guest]

Icing makes my dead zone worse. I use heat to make it better. The swelling

doesn't go down no matter what I do. I ignore it, and buy pants that fit in the

knees!

All the best, Joan

________________________________

From: Donna Rae <rae900@...>

Joint Replacement

Sent: Thu, May 20, 2010 1:20:52 PM

Subject: Re: question

My PT iced every time I went and encouraged me to keep doing it even after PT

was done. It sure took my swelling down and sometimes when I can sleep, I ice

and elevate with my pain pills. And it allows me to sleep.

Donna R

question

I had my tkr, April 14th and everything has been going great.� Well

yesterday my knee was very sore and today also?????� Has anyone else had

this problem and if so what did you do about it?� Thanks,

[Guest guest]

He just told me that I didn't need to ice my knee anymore??  LInda

From: on <jackiett@...>

Subject: Re: question

Joint Replacement

Date: Thursday, May 20, 2010, 12:29 PM

 

Hi ,

That doesn¹t sound right.

Not sure what exactly s/he said....Was it on the order of that you should

not ice anymore? Or that icing was no longer required as it was right after

your surgery? If the former, Was there a problem s/he was addressing by

telling you not to ice?

I know it can be problematic if we ice for too long or too often but never

heard that there was a time when we should stop.

Jackie

Did he say why to stop icing? To stop altogether? Or just that you didn¹t

need to continue in the same way?

J

>

> Re: question

>

> My os told me to stop icing????? 

>

>

>

>

[Guest guest]

The pants thing is a pain in the butt!!!!!! 

On Thu, 5/20/10, Joan Kell <kell_joan@...> wrote:

From: Joan Kell <kell_joan@...>

Subject: Re: question

Joint Replacement

Date: Thursday, May 20, 2010, 3:36 PM

 

Icing makes my dead zone worse. I use heat to make it better. The swelling

doesn't go down no matter what I do. I ignore it, and buy pants that fit in the

knees!

All the best, Joan

________________________________

From: Donna Rae <rae900@...>

Joint Replacement

Sent: Thu, May 20, 2010 1:20:52 PM

Subject: Re: question

My PT iced every time I went and encouraged me to keep doing it even after PT

was done. It sure took my swelling down and sometimes when I can sleep, I ice

and elevate with my pain pills. And it allows me to sleep.

Donna R

question

I had my tkr, April 14th and everything has been going great.� Well

yesterday my knee was very sore and today also?????� Has anyone else had

this problem and if so what did you do about it?� Thanks,

[Guest guest]

Oh, I understand. That sounds normal. Some I had the idea that he was

telling you: Do not ice! But it¡¯s just that he doesn¡¯t see icing as

needed ongoing. So you can ice if something cause pain or swelling....just

don¡¯t have to do it all the time anymore.

J

On 5/21/10 12:40 PM, " Banks " <lindabandcompany@...> wrote:

>

>

>

>

>

> He just told me that I didn't need to ice my knee anymore??? LInda

>

>

>

> From: on <jackiett@... <mailto:jackiett%40att.net> >

> Subject: Re: question

> Joint Replacement

> <mailto:Joint Replacement%40>

> Date: Thursday, May 20, 2010, 12:29 PM

>

> ?

>

> Hi ,

>

> That doesn©öt sound right.

>

> Not sure what exactly s/he said....Was it on the order of that you should

> not ice anymore? Or that icing was no longer required as it was right after

> your surgery? If the former, Was there a problem s/he was addressing by

> telling you not to ice?

>

> I know it can be problematic if we ice for too long or too often but never

> heard that there was a time when we should stop.

>

> Jackie

>

> Did he say why to stop icing? To stop altogether? Or just that you didn©öt

> need to continue in the same way?

>

> J

>

>