Re: Spindler's Mice - More Details

[Guest guest]

Rodney: not sure you're not confusing what I said. I have often said that

in OLDER individuals CR should be less severe. This is what Walford says

and I posted the link to Walford's page recently in this post:

/message/11241

But your data on older mice seems to contradict that (?????). I'm staying

on the moderation side just to be safe (I'm an " older " mouse)

OTOH, I do agree with what you suggest below. Gradual edging in is probably

a good idea and is much less of a shock to the body. This is what we

suggest in our file: " CR Made Easy " for beginners.

on 4/19/2004 12:33 PM, Rodney at perspect1111@... wrote:

> Here is one that may support Francesca's view about

> the desirability of edging into CR gradually:

[Guest guest]

Thanks Francesca.

I was under the impression your view was that ON should be

implemented 100% and immediately, but that CR should be implemented

gradually. Evidently I misunderstood. Sorry about that.

It could be argued this latest study lends some support to

the 'gradual onset' view. Perhaps it should be even more gradual

than the '25% CR for eighteen months' then '50% CR' of the study.

But it doesn't seem to lend much support to the idea that the

ultimate degree of restriction should be less if started at age 60-65.

Of course not all studies agree. I haven't seen the study which

showed danger in a high degree of restriction at older ages. Are we

sure it differentiated between the issues of 'gradual onset'

and 'ultimate degree of restriction'? They are easy to confuse (as I

note above!).

Of course, as Dr. Walford would freely acknowledge, he is " only one

mouse " . Even if a particularly interesting one! : ^ )))

Rodney.

>

> > Here is one that may support Francesca's view about

> > the desirability of edging into CR gradually:

[Guest guest]

Hi folks:

Another detail: The mice were fed only Monday, Wednesday and Friday

at 9:00 am. How much, if any, of the effect resulted from fasting?

I sure hope this doesn't mean we humans should only feed ourselves

every 80 days ; ^ )))

Rodney.

--- In , " Rodney " <perspect1111@y...>

wrote:

> Hi folks:

>

> The salient facts about Spindler's mice have already been posted I

> think. But there are some relatively minor details that are also

> worth noting

[Guest guest]

Hi folks:

I am going to run out of new snippets of information pretty soon.

But here is one more:

Between months 21 and 31 (the human-equivalent ages of 70 and 103),

the CR mice saw 75% fewer cancer deaths than the control mice.

Rodney.

--- In , " Rodney " <perspect1111@y...>

wrote:

> Hi folks:

>

> Another detail: The mice were fed only Monday, Wednesday and

Friday

> at 9:00 am.

[Guest guest]

Hi JW:

Funny you should say that. I have been wondering how it tastes!

Rodney.

--- In , " jwwright " <jwwright@e...>

wrote:

> You haven't yet got to the question: If we believe the mice studies

and the studies are applicable to humans, why don't we eat what the

mice ate?