Late-Life CR -- 16 Yrs Gained for 44 Pct CR

[Guest guest]

Column 1 on the far right is Spindler's data, where the

40 percent mean lifespan increase occurred for late-life

CR in mice who started at age 19 months when on average

they live to 30.8 months.

In human years, assuming an average lifespan of 100 years,

(which is the estimated age that 50 percent of the population

born today will live to if they steer clear of avoidable

diseases caused by smoking, alcohol, obesity, etc, according

to UC Berkeley Wellness Newsletter estimates), Spindler's

19 month-old mice started CR at a human equivalent age of

62 years:

19 mo X 100 yr / 30.8 mo = 61.69 years

The extra 5 months of avg lifespan gain by these 44% CR mice

is equivalent to 16 years of extra life:

5 mo X 100 yr / 30.8 mo = 16.23

44% CR for a human is certainly possible. There might be

several dozen or more of our CRFolks living this rigorous

level of CR, which though strict is still very possible.

For a younger person, the lifespan gain would be proportionally

much larger, certainly exceeding 20 years, thus achieving

and even exceeding the threshold value of the average

120 years given by Dr. Roy Walford in his books featuring

" The 120 Year Diet " .

The 16 years gain for late life CR, and the 120 years mean

lifespan are in good agreement with Bob Seitz's computations

in the webpages that he created to post his numbers. See

Bob's message below for his nice website and the lifespan

gains that he computes.

-- Warren

Proc Natl Acad Sci U S A. 2004 Mar 25 [Epub ahead of print]

ph M. Dhahbi, Hyon-Jeen Kim, L. Mote, J. Beaver,

and R. Spindler, " Temporal Linkage Between the Phenotypic

and Genomic Responses to Caloric Restriction " , PMID: 15044709,

[PubMed - as supplied by publisher]

-- Warren

http://www.pnas.org/cgi/content/abstract/0305300101v1

====================

On 040904, Bob Seitz wrote:

I have reframed Rae's table, adding a few lines that

I needed to better understand his numbers.

Citation (4) (2) (3) (1)

Strain C3B10F1 C3B10F1 C57BL6 C3B6F1

Age Initiated 1 12 12 19

Calories/week

AL 85 160 84 93

CR 50 90 62 52.2

%CR (vs AL) 41 44 26 44

Lifespan (months), AL:

Mean 33 31 30 30.8

Max 40 40.6 37.7 37.6

Lifespan (months), CR:

Mean 43 36.9 33.2 35.8

Max(longest Decile) 51 45.1 41.8 43.6

Lifespan Extension (months)

Mean 10 5.9 3.2 5.0

Max 11 4.5 4.1 6.0

% Lifespan Extension

Vs Total LS

Mean 30 19 11 15

Max 28 11 11 16

Vs. Remaining LS

Mean 31 18 16 40

Max 28 16 16 32

---------------------------------------------------------

.... I've also reformatted 's table in html format.

I'll be glad to put it on the website. Of course, only

this group would be privy to its web address or to its

existence. However, search engines might pick it up.

Should I do that? Or not?

On a related topic, here's my attempt at an exposition of

these results

TinyURL: http://tinyurl.com/2mjt9

LongURL: http://www.geocities.com/rnseitz/2004-4-8-Rejuvenation_Update.htm

At the present time, our main Mega Foundation website is down,

so I'm having to post this on my own private website.

The audience reading this material is small (I think) but

international, and consists of individuals many of whom are

at the 1:30,000-and-up level of intelligence (4+ sigma,

deviation IQ>= 164), as confirmed by various test instruments.

The Mega Foundation was established to try to find ways

to better harness the talents of the brightest members of

the population.