RE: L-Glutamine

[Guest guest]

<< Would there be any benefit in supplementing with L-glutamine, when a recent

blood test shows 611 nmol/ml - considered within normal limits. >>

Depends on what you are trying to accomplish with it.

You can always try it - the stuff isn't that expensive.

Remember to keep it dry and store it in a tightly closed container so it

doesn't hydrolyze to glutamate.

Andy

[Guest guest]

what would be reason sone would NOT want to take L=glutamine?

[Guest guest]

I had to take Austin off L-glutamine. He regressed terribly on it. I heard

from a few parents who saw similar regression. One mom was gfcf herself and

told me that she had a problem with it. Sorry I can't be more specific --

I've never seen anything official that there can be problems with it. I had

Austin on it because I heard such great things about it. Our DAN doctor is

going to do an amino acids test on Austin to see if there is a problem.

mom to Austin (recovered from pdd) and (nt)

5 yr old twins

In a message dated 7/7/01 6:45:24 PM Pacific Daylight Time,

SensoryMom@... writes:

> Subj:Re: [ ] L-glutamine

> Date:7/7/01 6:45:24 PM Pacific Daylight Time

> From: SensoryMom@...

> Reply-to: <A

HREF= " mailto: " > <\

/A>

>

>

>

>

>

> what would be reason sone would NOT want to take L=glutamine?

>

>

>

[Guest guest]

I'll let the list know what the results are. I have to wait until next

weekend because he has to be off all supplements for four days and then we

have to do a 24 hr urine collection.

In a message dated 7/7/01 7:40:05 PM Pacific Daylight Time,

kjorn@... writes:

> Subj:[ ] Re: L-glutamine

> Date:7/7/01 7:40:05 PM Pacific Daylight Time

> From: kjorn@...

> Reply-to: <A

HREF= " mailto: " > <\

/A>

>

>

>

>

>

> I could not find any specific side-effects either, but I think your

> observations overrule everything else. If Austin, or any other child,

> has an unexplained reaction, they shouldn't take it. IMHO. I have

> also heard other parents say their kids react even though glutamine

> is often recommended to help the gut.

>

> Our kids (and some of us adults) have special compromised systems and

> needs. Many of these reports may be talking about " average " persons.

> Biological creatures are quite unique.

>

> It would be cool if you could let us know if you find anything

> special about the amino acid test results.

>

> .

>

>

>

>

>

[Guest guest]

> what would be reason sone would NOT want to take L=glutamine?

I had to really search and only came up with these two references so

far, and one is somebody's personal post. There were many sites which

said there are no know side effects to glutamine, or no known side

effects. Most places are commenting on glutamine in doses of 5-20

grams/day. Kd.

If you perform any type of serious workout you should consider taking

a glutamine supplement. In addition, if you are going through any

type of stressful event or just trying to fight off the cold or flu -

glutamine can be very helpful.

The following people should NOT take glutamine:

- People with kidney problems

- People with cirrhosis of the liver

- People with Reye's syndrome

- Pregnant women

- Women who are breast feeding

http://www.nutritionhouse.com/page71.html

-------------------------------

From someone's post:

Side effects I experienced:

- Mouth and throat becomes very dry.

- Difficulty sleeping at night (this is not the symptom of

overtraining).

All in all, glutamine is highly recommended. I figured that the best

way to take it is to take 5-10 grams in morning on an empty stomach,

5 grams before or after training, 10 grams before sleeping. Please

consume more water before you sleep. Otherwise, sleeplessness tends

to happen.

http://www.nutritionalsupplements.com/glutamineR7.html

[Guest guest]

I could not find any specific side-effects either, but I think your

observations overrule everything else. If Austin, or any other child,

has an unexplained reaction, they shouldn't take it. IMHO. I have

also heard other parents say their kids react even though glutamine

is often recommended to help the gut.

Our kids (and some of us adults) have special compromised systems and

needs. Many of these reports may be talking about " average " persons.

Biological creatures are quite unique.

It would be cool if you could let us know if you find anything

special about the amino acid test results.

.

[Guest guest]

Where did you get the cream form? Is it a prescription?

Thanks,

Ann

[Guest guest]

Hi All - My son has been taking L-glutamine in cream form for the

past ten days now. We give it to him nightly and apply it on his

wrists and then rub in it. Up until yesterday, I had't noticed any

changes, positive or negative. Well, while he was serving as an

altar server at church last night, he wasn't fidgiting at all, just

very calm. He still wasn't paying as much attention as I would have

liked, (LOL) but at least there wasn't the usual squirming or playing

with his hands or twirling the cross around.

Also, his speech is pretty " labored " . Not stuttering or unclear, but

you always want to help him along when he's saying something or even

if he's reading. I noticed yesterday that his speech seem to be a

little more fluent. It was even more fluent when he read a little

bit out loud to me.

I'm not sure if it's because of the L-glutamine or a benefit of the

enzymes or what, but just thought I would share.

In @y..., kjorn@t... wrote:

> Here are some links to with brief information on L-glutamine. These

> are commercial sites, but you the general information is there. Kd.

>

> http://www.naturalhealthconsult.com/Monographs/glutamine.html

>

> http://www.thebody.com/step/summer99/haart.html

>

> http://hmscrown.com/L-Glutamine.html

>

> http://www.junycorp.com/soundness/l-glutamine.html

[Guest guest]

Hi Ann - Yes, the cream form that we have is from a prescription. We

got it from the Pfeiffer Center, where my son has been a patient now

for two years. The nurse said that they have been only using it for

a couple of months.

> Where did you get the cream form? Is it a prescription?

> Thanks,

> Ann

>

>

>

[Guest guest]

,

What improvements does the Pfeiffer Center say will occur with the

cream? Do you know if there are cases they do not recommend it for?

And just to know, have you been happy with your son's progress

through the Center?

Thanks.

.

> Hi Ann - Yes, the cream form that we have is from a prescription.

We

> got it from the Pfeiffer Center, where my son has been a patient

now

> for two years. The nurse said that they have been only using it

for

> a couple of months.

>

>

[Guest guest]

Hi - The improvements that the nurse said would vary, of

course, from child to child. They said that one father reported that

his son's small motor skills were greatly improved. Other than that

though, nothing much. She didn't give me any written material. She

did say that they had two forms, one that was a soy base and another

that was an almond base, I believe. We have the soy based one, even

though this same nurse wanted me to not only stay on the GF/CF diet,

but to take out soy also. I don't get that one. Anyway, overall, I

have been happy with the progress he's made at Pfeiffer. I did have

him on a bunch of supplements before we even started going there, but

they make changes to his treatment program.

I think I may have a correction though as to what this stuff is. Is

glutamine and glutathione the same thing? On the prescription I have

in front of me, I just noticed it was a different spelling. The

prescription reads as " Glutathione L Reduced 200 mg/ml " .

Sorry if I mislead anyone, it's a new cream for me too.

> > Hi Ann - Yes, the cream form that we have is from a

prescription.

> We

> > got it from the Pfeiffer Center, where my son has been a patient

> now

> > for two years. The nurse said that they have been only using it

> for

> > a couple of months.

> >

> >

[Guest guest]

On the topical, I read somewhere just this week that gluten molecules

are too big to pass through the skin. So things such as playdoh were

not to be given because they may end up under fingernails and

eventually get into the mouth. So if the soy molecules are also

considered too big to pass through the skin, this may explain why a

topical is being approved. I only read this once, so I don't know for

sure.

.

[Guest guest]

That's very interesting. It certainly makes me feel better about

it. I don't really know if my son has a problem with soy or not

(we're currently taking Devin's enzymes also), but I hope you're

right about it being too big to pass through to the skin. Thanks for

the info.

> On the topical, I read somewhere just this week that gluten

molecules

> are too big to pass through the skin. So things such as playdoh

were

> not to be given because they may end up under fingernails and

> eventually get into the mouth. So if the soy molecules are also

> considered too big to pass through the skin, this may explain why a

> topical is being approved. I only read this once, so I don't know

for

> sure.

>

> .

[Guest guest]

> Do you give L-Glutimine during chelation?

No. Why would you? It is helpful for some people, but that is all

the time and not related to chelating.

Andy

> How much should a child of

> 45lbs take every day

[Guest guest]

Liz wrote:

---

Message: 17

Date: Sat, 1 Dec 2001 21:24:26 -0800

From: " Liz G. " <pioneer@...>

Subject: L-glutamine

If you are using this, how much do you take and should you take it with

food? I have a bottle of 500mg tablets, and it says one per day, but

something I read yesterday about L-glutamine and ulcers said something like

1,600mg per day. Thanks, Liz G.

---

Liz,

Perhaps this article will be of some use:

http://www.healingyou.org/cgi-bin/showme.pl?p=../l-glutamine.html

(I haven't read it in awhile so I may be wrong as to if it will help or

not.)

Geoff

soli Deo gloria

[Guest guest]

I'm not sure I've ever seen glutamine mentioned as an " appetite

suppressant, " although I have seen it mentioned as an aid in diminishing a

yen for sweets....

Effective appetite suppressants free of side effects appear to still be a

bit elusive....

There are prescription meds that may suppress appetite, but it seems like

truely safe and effective ones have yet to be either discovered or

invented...

>From: " Peg Diamond " <enmuffins@...>

>Reply-

>

>Subject: [ ] L-Glutamine

>Date: Tue, 25 May 2004 16:51:23 -0000

>

>I'd be interested to know if any listees have used this for an

>apetite suppressant. I know it's used by athletes and I'm not an

>athlete by any stretch of the imagination but I would still like to

>see if anyone who has taken it can tell me how it worked for

>them.

>

>I've tried doing a 'search' of the archives but only lets me

>search 25 or 50 at a time - depending on how my prefs are set

>up. I know that in the past it was not that way and I could see any

>post in the archives that was appropriate - all the way back to the

>first post.

>

>If any listees have info I would appreciate it and maybe it could

>be sent to my email address rather than cluttering up the list.

>

>Canary Peg

>

>

>

[Guest guest]

Barbara

Magnesium needs vitamin B6 as it's cofactor. I take 200mg of Mg four to six

times daily without experiencing loose stools. In the earlier years of

FMS/CFIDS, my body needed closer to two grams of Mg daily. I also take 100 mg

B6

three times a day.

THis combination Mg and B6 has been incredibly effect in relieving muscle

spasms so severe they pulled the vertebrae out of alignment in my spine.

Malic acid is another form of Magnesium that may be helpful in relieving

spasms and increasing energy.

_www.mgwater.com_ (http://www.mgwater.com)

_www.exatest.com_ (http://www.exatest.com)

_www.magnesium.com_ (http://www.magnesium.com)

Hope this helps

mjh

In a message dated 10/25/2005 7:05:51 PM Eastern Daylight Time,

writes:

Date: Tue, 25 Oct 2005 15:00:57 -0400

From: " Barbara " <brfifield@...>

Subject: Re: Re: L-Glutamine

Hi Rich,

I have all the things you mentioned - muscle twitching (especially the

eyelids which is made worse with many single amino acids and some hormones ie.

DHEA), migraines and irregular heart rhythms. I was taking over twice the

magnesium to calcium ratio and still experiencing this so gave up completely on

calcium supplementation.

Interestingly enough, I started magnesium alone in higher doses about 3

weeks ago. I've built up to 900 mg. daily but have had to offset bowel

intolerance with several grams of vitamin C. Presumably, since most vitamin C

is

sourced from corn, that is the reason that it causes a constipating action with

me.

Although I feel calmer with the magnesium, I was hoping it would do

something to alleviate the hundreds of hard painful lumps (knots) in my back

but

unfortunately they are still there. Also, I've been having severe migraines for

about a week now but the barometer has been falling so that may be the cause.

Thanks for shedding some light on this for me. Any further direction?

Barbara

mjh

" The Basil Book "

http://foxhillfarm.us/FireBasil/

[Guest guest]

Hi mjh,

How many mg's of other B vit you take with 300 mg total daily b6 dosage?I

also wish to increase my B6 but don't want overdosing.

Thanks

nil

Re: Re: Re: L-Glutamine

>

>

> Barbara

>

> Magnesium needs vitamin B6 as it's cofactor. I take 200mg of Mg four to

> six

> times daily without experiencing loose stools. In the earlier years of

> FMS/CFIDS, my body needed closer to two grams of Mg daily. I also take

> 100 mg B6

> three times a day.

>

> THis combination Mg and B6 has been incredibly effect in relieving muscle

>

[Guest guest]

I would look into how it functions, if at all, in the glutamate loop.

For some reason I thought I remembered this being an issue. Here is a

link to an onibasu search that might help: http://onibasu.com/cgi-

bin/search.cgi?query=glutamine+glutamate & max=20 & sort=score & idxname=am

Anne

>

> Gosh, I'm sure this has been discussed in detail before, but I've

been

> reading such nice things about L-glutamine lately, how it helps with

> the gut lining, with the body's production of glutathione, that it's

a

> better substitute for GABA and so on. Has anyone used or been using

> this thing successfully? Any warnings, suggestions about it?

> Thanks so much for your time.

> Beti

>

[Guest guest]

Hi beti; We have been using for almost 19months; and for my son it

has been very usefull; I dont want to esagerate; but my son has been

taking the Kirkman L-glutamina 1cp for x3 a day (3tab a day) and he

couldnt tollerate glutine before; and now we have noticed that he

can eat gluten withaout no-more reaction; no regression; he is only

getting better! I dont think it is only L.glutamine but I do believe

it did contribute alot to it! and for this reason We are even afraid

of going back normal diet; he eats breakfast cookies and some times

snaks with glutine; and he tollerates it!

Since I am gastroenterologist recently I have read alot of article

of positive impact glutamine has in GI tract; it has even a positive

impact on many proteins in gastrointestinal cells!

If you need the article i will post it.

bye fardi

> >

> > Gosh, I'm sure this has been discussed in detail before, but

I've

> been

> > reading such nice things about L-glutamine lately, how it helps

with

> > the gut lining, with the body's production of glutathione, that

it's

> a

> > better substitute for GABA and so on. Has anyone used or been

using

> > this thing successfully? Any warnings, suggestions about it?

> > Thanks so much for your time.

> > Beti

> >

>

[Guest guest]

Hi beti; this is one of the article i have found very interesting

regarding positive effect of glutamine!

fardi

Medeiros AC, Chacon DA, Sales VS, Egito ES, Brandão-Neto J, Pinheiro

LA, Carvalho MR

Glucan and glutamine reduce bacterial translocation in rats

subjected to intestinal ischemia-reperfusion.

J Invest Surg. 2006 Jan-Feb; 19 (1):39-46.

PMID: 16546928

Postgraduate Program in Health Sciences, Federal University of Rio

Grande do Norte, Natal, Brazil. aldo@...

Intestinal ischemia/reperfusion (I/R) may induce bacterial

translocation (BT). Glutamine (GLN)-enriched nutrition decreases BT.

However, little is known about the effect of glucan (GL) in BT. This

study investigated the combined effect of GL/GLN on BT, intestinal

damage, and portal blood cytokines in animals under I/R. Four groups

of 10 rats each were subjected to 60 min of intestinal ischemia and

120 min of reperfusion. The control group (group 1) received only

rat food/water, group 2 received glutamine via gavage, group 3

received subcutaneuos soluble (1, 3)-d-glucan, and group 4 received

GL + GLN. A sham group (group 5) served as a normal control.

Bacterial cultures of ileum, mesenteric lymph nodes (MLN), liver and

lung biopsies, histological changes of ileum, and serum cytokines

variables were examined after I/R. Data were analyzed by analysis of

variance (ANOVA) and the Newman-Keuls test. Results showed that GLN,

GL, and GL/GLN significantly reduced BT to MLN, liver, and lung. BT

was more attenuated after GL treatment than GLN (P < .05). Rats

treated with both GL and GLN exhibited lower bacterial colony counts

than the ones treated only with GLN or GL. Severe mucosal damage on

histological findings was shown in group 1, but these findings were

significantly ameliorated (P < .05) in groups 3 and 4. Tumor

necrosis factor (TNF)-a and interleukin (IL)-6 levels in portal

serum were significantly reduced and IL-10 was increased by GL and

GLN treatment. In conclusion, the use of GL was more effective than

GLN in reducing BT, intestinal damage, and cytokine levels after

I/R. Additionally, the combination of GL and GLN improved resu

> > >

> > > Gosh, I'm sure this has been discussed in detail before, but

> I've

> > been

> > > reading such nice things about L-glutamine lately, how it

helps

> with

> > > the gut lining, with the body's production of glutathione,

that

> it's

> > a

> > > better substitute for GABA and so on. Has anyone used or been

> using

> > > this thing successfully? Any warnings, suggestions about it?

> > > Thanks so much for your time.

> > > Beti

> > >

> >

>

[Guest guest]

This is another article which I found very usefull! L.glutamine

could be usefull in many reasons for aur kids!

fardi

Nascimento SB, Sousa RB, s MJ, Souza Gomes A, Souza MH,

Guerrant RL, Cunha FQ, Ribeiro RA, Brito GA

Glutamine depletion potentiates leucocyte-dependent inflammatory

events induced by carrageenan or Clostridium difficile toxin A in

rats.

Immunology. 2005 Nov; 116 (3):328-36.

PMID: 16236122

Department of Physiology and Pharmacology, The Federral University

of Ceará, Fortaleza, CE, Brazil.

This research investigated the effect of glutamine (Gln) depletion

on leucocyte-dependent inflammatory events. Rats were treated

intraperitoneally, 16 hr prior to the peak of every parameter

evaluated, with either 0.9% NaCl, methionine-sulphoximine (MSO, an

inhibitor of endogenous Gln synthesis, 25 mg/kg) or with MSO + Gln

(MSO as above plus Gln 3 g/kg in three doses). MSO-induced Gln

depletion increased paw oedema induced both by carrageenan (Cg) and

by Clostridium difficile toxin A (TxA) (66.2% and 45.5%,

respectively; P < 0.05). In dextran-injected animals, oedema and

myeloperoxidase (MPO) activity were not modified by Gln depletion.

In Cg-treated paws, Gln depletion increased MPO activity by 44% (P <

0.05), interleukin-1beta (IL-1beta) and tumour necrosis factor-alpha

(TNF-alpha) concentrations by 47% and 52%, respectively (P < 0.05),

and immunostaining for TNF-alpha in paw tissue. In TxA-injected

paws, Gln depletion increased MPO activity (46%; P < 0.05). Gln

depletion increased Cg- and TxA-induced neutrophil migration to

subcutaneous air pouches by 56% and 77% (P < 0.05), respectively,

but did not affect migration induced by N-formyl-methionyl-leucyl-

phenylalanine (fMLP). Gln infusions reversed all the effects of MSO.

Leucocyte counts did not differ between groups. Gln depletion

potentiates acute inflammation, possibly by increasing neutrophil

migration through resident cell activation and production of IL-

1beta and TNF-alpha. Gln supplementation reverses these effects and

may be useful during inflammatory catabolic stress.

> > > >

> > > > Gosh, I'm sure this has been discussed in detail before, but

> > I've

> > > been

> > > > reading such nice things about L-glutamine lately, how it

> helps

> > with

> > > > the gut lining, with the body's production of glutathione,

> that

> > it's

> > > a

> > > > better substitute for GABA and so on. Has anyone used or

been

> > using

> > > > this thing successfully? Any warnings, suggestions about it?

> > > > Thanks so much for your time.

> > > > Beti

> > > >

> > >

> >

>

[Guest guest]

Hi Fardi, thank you soo much for taking the time to post those

articles and write about your experience. Thusfar, my own reading

overwhelmingly points to good stuff about glutamine as well, so I

think I am ready to give it a shot.

As with every new thing that we decide to start, I am excited and

full of hope. Glad to hear that your little one is getting better

and better. May you see more of the good stuff.

Best,

Beti

> > >

> > > Gosh, I'm sure this has been discussed in detail before, but

> I've

> > been

> > > reading such nice things about L-glutamine lately, how it

helps

> with

> > > the gut lining, with the body's production of glutathione,

that

> it's

> > a

> > > better substitute for GABA and so on. Has anyone used or been

> using

> > > this thing successfully? Any warnings, suggestions about it?

> > > Thanks so much for your time.

> > > Beti

> > >

> >

>

[Guest guest]

--- I've read that it can increase ammonia. Ammonia can be a problem

with bacteria and maybe yeast.

In , " asd.mom3 " <alawson@...> wrote:

>

> L-glutamine was recommended for my 3yr old with leaky gut for this

> specific purpose. Has anyone used it and if so any negatives to look

> out for?

>

[Guest guest]

Here is a little write-up on the glutamate and autism issue. A little

technical and maybe not the whole story but it shows that this is a

known problem in autism related conditions:

http://www.springboard4health.com/notebook/health_autism2.html#11

.

==============================

The Glutamate Connection

Glutamate (made from glutamine and one form is glutamic acid) is the

main excitatory neurotransmitter and is essential for learning,

attention, focus and memory. Interestingly, it is also the precursor

of a calming neurotransmitter called GABA.

GABA is a neurotransmitter that engenders a feeling of peaceful

satisfaction. It is also important in the acquisition of speech, as

it helps us to distinguish between the onset of a sound and

background noise. This can lead to sensory overload. Low GABA levels

make seizure activity more likely.

The enzyme that converts glutamate to GABA (glutamic acid

decarboxylase) also requires vitamin B6 as a cofactor for its

activity. Vitamin B6 plays a role in many chemical reactions

pertinent to reversing autism and is one of the nutrients that has

shown great success in this regard.

In autistic children there is often a failure to convert glutamate to

GABA in sufficient amounts. This results in an imbalance that results

in too much neuronal excitation (which can lead to " stimming "

behaviors) and too little GABA calming (which can lead to speech

impairment).

One of the frequent findings in autistic children is the presence of

a chronic viral infection (like measles). Viral infections are known

to inhibit the conversion of glutamate to GABA. Excess copper, a

common finding in 85% or more autistic individuals, also inhibits

GABA.

Excess glutamate can damage and even kill neurons. It does this by

generating free radicals in the cells that it over-excites. Glutamate

also stimulates the production of glucose, the chief energy molecule

for the brain. When glucose levels are low the brain has difficulty

clearing the excess glutamate, and excess glutamate depletes

glutathione, a potent antioxidant that protects neurons from

oxidative damage and toxic metal poisoning.

One of the sic receptors that glutamate attaches to is known as the

NMDA receptor. When glutamate or other excitatory compound (like

aspartate) land on this receptor they open a channel that allows

calcium into the cell. It's the calcium in the cell that causes the

excitation in the cell. Excessive influx of calcium damages the

neuron. This can be blocked with magnesium and zinc and both of these

elements have been used successfully as supplements for autism.

There is also a direct connection between mercury toxicity and

glutamate. Researchers have recently discovered that methyl mercury

won't damage neurons unless glutamate is present (Aschner, et

al, " Methyl Mercury Alters Glutamate Transport in Astrocytes "

NeuroChem Intl 2000; 37:199). This suggests that excess glutamate

will potentiate the toxicity of even low levels of mercury.

So, do autistic children exhibit elevated levels of these excitatory

neurotransmitters? Yes, research shows that both glutamate and

aspartic acid are elevated in individuals exhibiting autistic

tendencies. There is also some evidence indicating that autistic

children also possess increased numbers of glutamine receptors. This

isn't all bad, however, as research (Joe Tsien of Princeton in Sept

2, 1999 Nature) has shown a link between increased numbers of

glutamine receptors in mice and a superior ability to learn and

memorize.