Re: Re: Seven-year study suggests longer life comes from higher metabolism

[Guest guest]

Ok. I want to be sure that I'm understanding this correctly. I've always

had a " fast " metabolism i.e. For the vast majority of my life I was always

able to eat a lot and not gain any weight (in fact I was what could be

called " skinny " ). This ended just a few short years ago, relatively late

in my life. Am I an example of who they are talking about here?

on 6/24/2004 11:12 AM, aequalsz at aequalsz@... wrote:

>

>> Hi folks:

>>

>> http://www.betterhumans.com/News/news.aspx?articleID=2004-05-31-2

>>

>> http://snipurl.com/7al5

>>

>> Rodney.

>

> Another, slightly different version.

>

> http://www.news-medical.net/default.asp?id=2079

>

> From the article,

>

> ------------------------------------------------------------------

> Professor Speakman added: " This is the first direct information on

> individuals within one species and the result is striking: living

> fast means dying old. "

>

> Dr Brand, leader of the research team at the MRC Dunn Human

> Nutrition Unit in Cambridge added: " This finding gives us the first

> hint of a new way to try to achieve an increase in lifespan in

> humans by lowering our metabolic efficiency so that we burn more

> energy. "

> -------------------------------------------------------------------

>

> This article is a good rationale to hedge your bets and not go

> overboard on an extreme CRON diet IMHO.

>

> A

>

>

>

>

[Guest guest]

For the shallow-thinking among us, would someone care to explain why

this is not a complete repudiation of CRON?

And if not, how the two theories fit together and how to get the

benefits of both.

Don

aequalsz wrote:

Hi folks:

http://www.betterhumans.com/News/news.aspx?articleID=2004-05-31-2

http://snipurl.com/7al5

Rodney.

Another, slightly different version.

http://www.news-medical.net/default.asp?id=2079

>From the article,

------------------------------------------------------------------

Professor Speakman added: "This is the first direct information on individuals within one species and the result is striking: living fast means dying old."

Dr Brand, leader of the research team at the MRC Dunn Human Nutrition Unit in Cambridge added: "This finding gives us the first hint of a new way to try to achieve an increase in lifespan in humans by lowering our metabolic efficiency so that we burn more energy." -------------------------------------------------------------------

This article is a good rationale to hedge your bets and not go overboard on an extreme CRON diet IMHO.

A

[Guest guest]

Thanks for asking the question - I was thinking the same thing

----- Original Message -----

From: Don Libes

Sent: Thursday, June 24, 2004 11:01 AM

Subject: Re: [ ] Re: "Seven-year study suggests longer life comes from higher metabolism"

For the shallow-thinking among us, would someone care to explain why this is not a complete repudiation of CRON?

[Guest guest]

Well, first off, I'm not a medical researcher, and I know about as much

as the next guy, mostly from reading the article. However, this is the

part that I found interesting in regards to what you just said:

When the muscles of the most metabolically active mice were examined,

they were found to contain factors that increased their metabolism

by

making it less efficient.

Although the scientists do not yet fully understand how these factors

work, it is suspected that while they make the metabolism less

efficient, on the positive side they reduce the generation of toxic

by-products called " oxygen free radicals " .

The first paragraph says to me that the high metabolism was not really a

result of what they ate, but really a result of how their body dealt

with what they ate. The study doesn't say anything about what the

difference in lifespan between high metabolism mice was depending on the

diet that was fed to them.

In order to really disprove CRON on this one, you would have to have to

run an experiment that would basically have these groups.

1) slow metabolism, ad lib food

2) slow metabolism, restricted food

3) normal met., ad lib

4) normal met., restricted

5) fast met., ad lib

6) fast met., restricted

That way you would be able to see the differences in food control on

different metabolisms (get rid of some of those loose variables in

there). Hence, they might find that metabolism is just another factor

in life extension, so those with fast metabolisms would live longer, and

if they restricted the amount of food that they ate, they would live

even longer than that.

So, my long winded conclusion here is that I don't think that this

disproves CRON (actually, I think far from it), though it might throw

into doubt some of the 'extreme' CRON that some people do, and which

slows down their metabolism greatly.

However, one study does not a conclusion make. (it does, however, make

large amounts of speculation based on some numbers)

marc

Don Libes wrote:

> For the shallow-thinking among us, would someone care to explain why

> this is not a complete repudiation of CRON?

>

> And if not, how the two theories fit together and how to get the

> benefits of both.

>

> Don

>

> aequalsz wrote:

>

>>--- In , " Rodney " <perspect1111@y...>

>>wrote:

>>

>>

>>>Hi folks:

>>>

>>>http://www.betterhumans.com/News/news.aspx?articleID=2004-05-31-2

>>>

>>>http://snipurl.com/7al5

>>>

>>>Rodney.

>>>

>>>

>>

>>Another, slightly different version.

>>

>>http://www.news-medical.net/default.asp?id=2079

>>

>>>From the article,

>>

>>------------------------------------------------------------------

>>Professor Speakman added: " This is the first direct information on

>>individuals within one species and the result is striking: living

>>fast means dying old. "

>>

>>Dr Brand, leader of the research team at the MRC Dunn Human

>>Nutrition Unit in Cambridge added: " This finding gives us the first

>>hint of a new way to try to achieve an increase in lifespan in

>>humans by lowering our metabolic efficiency so that we burn more

>>energy. "

>>-------------------------------------------------------------------

>>

>>This article is a good rationale to hedge your bets and not go

>>overboard on an extreme CRON diet IMHO.

>>

>>A

>>

>>

>>

>>

>>

>>

>>

[Guest guest]

Doesn't this also fly in the face of " too much exercise is bad? " If lots

of exercise is one way to get " thin " ?

on 6/24/2004 1:22 PM, aequalsz at aequalsz@... wrote:

>

>> For the shallow-thinking among us, would someone care to explain

> why

>> this is not a complete repudiation of CRON?

>>

>> And if not, how the two theories fit together and how to get the

>> benefits of both.

>>

>> Don

>>

>

>

> My guess is that " thin " is good for longevity. Whether it is due to

> a hyperactive metabolism or a CRON diet or a combination of both.

> Mainly to avoid obesity related health problems. (Or maybe over-

> oxidation due to free radicals. Also fat seems to be a good way to

> store toxic elements - not good).

>

> Anyone notice that animal studies seem to show a lessoning of

> effectiveness of CRON diets to extend lifespan for larger, longer-

> lived animals? Am thinking about a study of some Labrador Retriever

> dogs who had a 15% increase in lifespan due to a CRON diet. But

> vaguely remember something about mice and fruit flies that lived

> proportionately much longer than that. Am wondering if by the time

> you get to Homo Sapiens that the CRON effect will not be too

> significant in extending lifespan.

>

> aequalsz

>

>

>

>