Re: Vitamin D, Lithocholic Acid and Colon Cancer

[Guest guest]

Aspirin:

http://my.webmd.com/content/article/81/96946.htm

>From: " Rodney " <perspect1111@...>

>Reply-

>

>Subject: [ ] Vitamin D, Lithocholic Acid and Colon Cancer

>Date: Sun, 27 Jun 2004 23:11:40 -0000

>

>Hi folks:

>

>1. Quite an interesting article (but it is two years old now):

>

>http://www.cancer.org/docroot/NWS/content/NWS_1_1x_Vitamin_D_Protects_

>Against_Colon_Cancer.asp

>

>http://snipurl.com/7db2

>

>2. I was trying to put together a list of things that protect

>against colon cancer. Here it is. Would anyone like to add to it?

>

>Insoluble fibre.

>Statins.

>Vitamin E.

>Calcium.

>Coffee.

>Copper.

>Folic acid.

>Exercise.

>Avoid red meats.

>Cruciferous vegetables.

>CR.

>Colonoscopies.

>

>Many of the above preventive measures are claimed to reduce cancer

>probability by 50%. So if one does seven of them does that reduce

>your chances to less than 1%? (0.5 ^ 7 x 100)%

>

>Rodney.

>

[Guest guest]

Hi :

Thank you.

Also I forgot garlic as protective against colon cancer (Source:

Iowa Women's Health Study)

Rodney.

> Aspirin:

>

> http://my.webmd.com/content/article/81/96946.htm

>

>

> >From: " Rodney " <perspect1111@y...>

> >Reply-

> >

> >Subject: [ ] Vitamin D, Lithocholic Acid and Colon

Cancer

> >Date: Sun, 27 Jun 2004 23:11:40 -0000

> >

> >Hi folks:

> >

> >1. Quite an interesting article (but it is two years old now):

> >

>

>http://www.cancer.org/docroot/NWS/content/NWS_1_1x_Vitamin_D_Protects

_

> >Against_Colon_Cancer.asp

> >

> >http://snipurl.com/7db2

> >

> >2. I was trying to put together a list of things that protect

> >against colon cancer. Here it is. Would anyone like to add to it?

> >

> >Insoluble fibre.

> >Statins.

> >Vitamin E.

> >Calcium.

> >Coffee.

> >Copper.

> >Folic acid.

> >Exercise.

> >Avoid red meats.

> >Cruciferous vegetables.

> >CR.

> >Colonoscopies.

> >

> >Many of the above preventive measures are claimed to reduce cancer

> >probability by 50%. So if one does seven of them does that reduce

> >your chances to less than 1%? (0.5 ^ 7 x 100)%

> >

> >Rodney.

> >

[Guest guest]

The only thing that will guarantee protection against colon cancer is a colonoscopy.

Those other things are associations.

If you check duke's database you will find thousands of anti cancer associations.

Because of the way a cancer works, I find it hard to believe any food chemical will prevent any cancer, and I don't believe red meats cause cancer, even thought I seldom eat it.

My perusal of prostate cancer docs (the only one I concern myself with), indicates to me inflammation is where it starts. So I use NSAIDS. Some herbs contain a natural NSAID, maybe even a natural source of chemo, but not in sufficient quantity.

Cancers seem to feed on excess food so I think a minimizing of food slows its growth. That's another reason for CR, IMO. I'm not so sure the lowered temperature is conducive to slower cancer growth, however. Maybe someone has some ideas about that.

In my case (HTN), I think even HTN meds will slow cancer growth because the fluid flow, and the nutrient flow that comes with it, is held down to normal levels.

Regards.

----- Original Message -----

From: Rodney

Sent: Sunday, June 27, 2004 6:11 PM

Subject: [ ] Vitamin D, Lithocholic Acid and Colon Cancer

Hi folks:1. Quite an interesting article (but it is two years old now):http://www.cancer.org/docroot/NWS/content/NWS_1_1x_Vitamin_D_Protects_Against_Colon_Cancer.asphttp://snipurl.com/7db22. I was trying to put together a list of things that protect against colon cancer. Here it is. Would anyone like to add to it?Insoluble fibre.Statins.Vitamin E.Calcium.Coffee.Copper.Folic acid.Exercise.Avoid red meats.Cruciferous vegetables.CR.Colonoscopies.Many of the above preventive measures are claimed to reduce cancer probability by 50%. So if one does seven of them does that reduce your chances to less than 1%? (0.5 ^ 7 x 100)%Rodney.

[Guest guest]

> Calcium.

I would point out this is likely an effect of inorganic calcium that

is unassimilated in the bowel, not organic.

> Coffee.

I think you should search up the negative effects of coffee on the

bowel mucoidal lining.

> Copper.

> Folic acid.

> Exercise.

> Avoid red meats.

> Cruciferous vegetables.

> CR.

> Colonoscopies.

None of the above is as effective as bowel detoxification in terms of

inducing peristalisis and vacuuming out fecal matter (with fiber-like

blends of drawing substances) and healing up any polyphs and

diverticulosis. Once every season is a good preventive measure.

Logan

[Guest guest]

I couldn't find the calcium study I had in mind. However, I believe

the study concluded or theorized that the unabsorbed inorganic

calcium from dietary supplementation acted as a protective effect in

the colon.

The coffee studies seem to be contradictory. I've ***emphasized***

in two references below.

There are many substances that can act both as a " colon vacuum " and

pathology inhibitor, not just the unique substance referenced below.

As it says in the reference, this is an " emerging field " -- at least

when it comes to published science!

Rodney, here are other substances (with published science backing) to

add to your list:

Green Tea

Selenium

Resveratrol

EPA and DHA

Vitamins A

Vitamins D

Tocotrienols

Modified Citrus Pectin

Logan

Effect of differently processed coffee on the gastric potential

difference and intragastric pH in healthy volunteers.

Ehrlich A, Basse H, Henkel-Ernst J, Hey B, Menthe J, Lucker PW.

Medical Department Phase I, Institut fur Klinische Pharmakologie

Bobenheim, Grunstadt, Germany.

The gastric irritation potential of orally administered coffee (150

ml) was investigated in four healthy volunteers by continuous

measurement of gastric potential difference (GPD) and intragastric

pH. Furthermore, serum gastrin concentrations were measured up to 45

min after administration of the coffee. One of the coffees,

untreated, had to be compared with a pretreated coffee. The

evaluation of the target parameters Reiz-Index, AUB, Pdmax and ttot

revealed a significant difference between untreated coffee and

specially treated coffee: the improved coffee processing produced

***significantly less mucosal irritation***. Regarding the

intragastric pH, no significant differences between the treatments

were observed and no stimulation of gastric acid secretion following

coffee was measurable. No consistent effect on serum gastrin

concentration was seen: two of the four subjects had a steep increase

in serum gastrin following administration with a clear difference

between the differently processed coffees, whereas the other two

subjects showed no change in serum gastrin. The results of this pilot

study confirm the findings of former experiments on the reliability

of continuous transmural GPD measurement when investigating the

mucosal irritation potential of barrier breakers.

Publication Types:

Clinical Trial

Randomized Controlled Trial

PMID: 9604858 [PubMed - indexed for MEDLINE]

The effect of unfiltered coffee on potential biomarkers for colonic

cancer risk in healthy volunteers: a randomized trial.

Grubben MJ, Van Den Braak CC, Broekhuizen R, De Jong R, Van Rijt L,

De Ruijter E, s WH, Katan MB, Nagengast FM.

Department of Gastroenterology and Hepatology, University Hospital

Nijmegen, The Netherlands. m.grubben@...

BACKGROUND: Epidemiologic studies suggest that coffee use might

protect against colorectal cancer. Inconsistencies as to the effect

of coffee use and colorectal cancer between epidemiologic studies

might be related to the type of coffee brew. OBJECTIVE: We studied

the effect of unfiltered coffee consumption on putative biomarkers

for colonic cancer risk. DESIGN: A total of 64 healthy volunteers (31

men and 33 women), with a mean age of 43 +/- 11 years were randomly

assigned to two groups in a crossover design, with two intervention

periods of 2 weeks separated by a washout period of 8 weeks.

Treatments were 1 L of cafetiere (French press) coffee daily or no

coffee. At the end of each intervention period, fasting blood

samples, colorectal biopsies and 48 h faeces were collected. RESULTS:

No effect of coffee on colorectal cell proliferation, assayed by

estimating the Proliferating Cell Nuclear Antigen labelling index,

was seen. Additionally, no effects were seen on the concentrations of

faecal soluble bile acids and colorectal mucosal glutathione S-

transferase activity. However, unfiltered coffee significantly

increased the glutathione content in the colorectal mucosa by 8% and

in plasma by 15%. Other aminothiols in plasma also increased on

coffee. CONCLUSION: ***Unfiltered coffee does not influence the

colorectal mucosal proliferation rate***, but might increase the

detoxification capacity and anti-mutagenic properties in the

colorectal mucosa through an increase in glutathione concentration.

Whether this effect indeed contributes to a lower colon cancer risk

remains to be established.

Publication Types:

Clinical Trial

Randomized Controlled Trial

PMID: 10971235 [PubMed - indexed for MEDLINE]

Inhibition of human cancer cell growth and metastasis in nude mice by

oral intake of modified citrus pectin.

Nangia-Makker P, Hogan V, Honjo Y, Baccarini S, Tait L, Bresalier R,

Raz A.

Wayne State University, School of Medicine, and Department of

Pathology, Karmanos Cancer Institute, Detroit, MI, USA.

BACKGROUND: The role of dietary components in cancer progression and

metastasis is an emerging field of clinical importance. Many stages

of cancer progression involve carbohydrate-mediated recognition

processes. We therefore studied the effects of high pH- and

temperature-modified citrus pectin (MCP), a nondigestible, water-

soluble polysaccharide fiber derived from citrus fruit that

specifically inhibits the carbohydrate-binding protein galectin-3, on

tumor growth and metastasis in vivo and on galectin-3-mediated

functions in vitro. METHODS: In vivo tumor growth, angiogenesis, and

metastasis were studied in athymic mice that had been fed with MCP in

their drinking water and then injected orthotopically with human

breast carcinoma cells (MDA-MB-435) into the mammary fat pad region

or with human colon carcinoma cells (LSLiM6) into the cecum. Galectin-

3-mediated functions during tumor angiogenesis in vitro were studied

by assessing the effect of MCP on capillary tube formation by human

umbilical vein endothelial cells (HUVECs) in Matrigel. The effects of

MCP on galectin-3-induced HUVEC chemotaxis and on HUVEC binding to

MDA-MB-435 cells in vitro were studied using Boyden chamber and

labeling assays, respectively. The data were analyzed by two-sided

Student's t test or Fisher's protected least-significant-difference

test. RESULTS: Tumor growth, angiogenesis, and spontaneous metastasis

in vivo were statistically significantly reduced in mice fed MCP. In

vitro, MCP inhibited HUVEC morphogenesis (capillary tube formation)

in a dose-dependent manner. In vitro, MCP inhibited the binding of

galectin-3 to HUVECs: At concentrations of 0.1% and 0.25%, MCP

inhibited the binding of galectin-3 (10 micro g/mL) to HUVECs by

72.1% (P =.038) and 95.8% (P =.025), respectively, and at a

concentration of 0.25% it inhibited the binding of galectin-3 (1

micro g/mL) to HUVECs by 100% (P =.032). MCP blocked chemotaxis of

HUVECs toward galectin-3 in a dose-dependent manner, reducing it by

68% at 0.005% (P<.001) and inhibiting it completely at 0.1% (P<.001).

Finally, MCP also inhibited adhesion of MDA-MB-435 cells, which

express galectin-3, to HUVECs in a dose-dependent manner.

CONCLUSIONS: MCP, given orally, inhibits carbohydrate-mediated tumor

growth, angiogenesis, and metastasis in vivo, presumably via its

effects on galectin-3 function. These data stress the importance of

dietary carbohydrate compounds as agents for the prevention and/or

treatment of cancer.

PMID: 12488479 [PubMed - indexed for MEDLINE]

> And the scientific evidence for your statements is............?????

>

>