Re: Seven-year study suggests longer life comes from higher metabolism

[Guest guest]

--- In , " Rodney " <perspect1111@y...>

wrote:

> Hi folks:

>

> http://www.betterhumans.com/News/news.aspx?articleID=2004-05-31-2

>

> http://snipurl.com/7al5

>

> Rodney.

Another, slightly different version.

http://www.news-medical.net/default.asp?id=2079

From the article,

------------------------------------------------------------------

Professor Speakman added: " This is the first direct information on

individuals within one species and the result is striking: living

fast means dying old. "

Dr Brand, leader of the research team at the MRC Dunn Human

Nutrition Unit in Cambridge added: " This finding gives us the first

hint of a new way to try to achieve an increase in lifespan in

humans by lowering our metabolic efficiency so that we burn more

energy. "

-------------------------------------------------------------------

This article is a good rationale to hedge your bets and not go

overboard on an extreme CRON diet IMHO.

A

[Guest guest]

> Ok. I want to be sure that I'm understanding this correctly. I've

always

> had a " fast " metabolism i.e. For the vast majority of my life I

was always

> able to eat a lot and not gain any weight (in fact I was what

could be

> called " skinny " ). This ended just a few short years ago,

relatively late

> in my life. Am I an example of who they are talking about here?

>

>

Sounds like it to me, but who knows? Any medical or biology experts

out there?

Another slightly different version of the article. (Last time I

promise.)

http://www.nature.com/nsu/040531/040531-2.html

A

[Guest guest]

> For the shallow-thinking among us, would someone care to explain

why

> this is not a complete repudiation of CRON?

>

> And if not, how the two theories fit together and how to get the

> benefits of both.

>

> Don

>

My guess is that " thin " is good for longevity. Whether it is due to

a hyperactive metabolism or a CRON diet or a combination of both.

Mainly to avoid obesity related health problems. (Or maybe over-

oxidation due to free radicals. Also fat seems to be a good way to

store toxic elements - not good).

Anyone notice that animal studies seem to show a lessoning of

effectiveness of CRON diets to extend lifespan for larger, longer-

lived animals? Am thinking about a study of some Labrador Retriever

dogs who had a 15% increase in lifespan due to a CRON diet. But

vaguely remember something about mice and fruit flies that lived

proportionately much longer than that. Am wondering if by the time

you get to Homo Sapiens that the CRON effect will not be too

significant in extending lifespan.

aequalsz

[Guest guest]

Hi All,

It seems to me that something like a 28% increased longevity comes

from weight loss and the rest are other factors in CR.

Things such as diabetes should improve for ad libbers with weight

loss. Does not true CR begin below the level at which diabetes is no

longer a significant health risk?

Fat tissue is good to store energy and produces many important

hormones. Toxins are a minor factor in my estimation.

Hyperthyroid people do not live longer than most healthy folks, I

believe.

Al Pater.

> > For the shallow-thinking among us, would someone care to explain

> why

> > this is not a complete repudiation of CRON?

> >

> > And if not, how the two theories fit together and how to get the

> > benefits of both.

> >

> > Don

> >

>

>

> My guess is that " thin " is good for longevity. Whether it is due

to

> a hyperactive metabolism or a CRON diet or a combination of both.

> Mainly to avoid obesity related health problems. (Or maybe over-

> oxidation due to free radicals. Also fat seems to be a good way to

> store toxic elements - not good).

>

> Anyone notice that animal studies seem to show a lessoning of

> effectiveness of CRON diets to extend lifespan for larger, longer-

> lived animals? Am thinking about a study of some Labrador

Retriever

> dogs who had a 15% increase in lifespan due to a CRON diet. But

> vaguely remember something about mice and fruit flies that lived

> proportionately much longer than that. Am wondering if by the time

> you get to Homo Sapiens that the CRON effect will not be too

> significant in extending lifespan.

>

> aequalsz

[Guest guest]

Hi Don:

I do not have any strong conviction about HOW this latest study fits

in with CRON.

But I do have a great deal of conviction that in order to supply " a

complete repudiation of CRON " we would need to see studies in mice

that show those which are fed fewer calories live shorter lives than

those that are fed more. That doesn't seem very likely any time

soon - unless all the previous CR studies are fraudulent (which I do

not believe even in my wildest dreams. There have been just too many

studies done by too many different investigators on too many

different species for that to be plausible).

This latest study is just another piece of a complex jig-saw puzzle,

and it is not immediately obvious, yet, how all the pieces fit. But

they do fit.

This latest study MAY show a way - via methods of decreasing

metabolic efficiency - whereby metabolically inefficient, 40%

restricted mice are shown to live even longer than the metabolically

efficient, 40% restricted, control mice.

But at this stage none of us know. It is fun to speculate but I

rather doubt we will be able to come up with the obvious explanation

before midnight ; ^ )))

Rodney.

> For the shallow-thinking among us, would someone care to explain

why

> this is not a complete repudiation of CRON? ................

[Guest guest]

Hi folks:

But while we are all still speculating and 8½ more hours remain

before midnight ............. one possible explanation may be that

those who have a naturally higher BASAL metabolic rate may be using

that extra energy to do a much more thorough job of tissue

maintenance and repair, and hunting down errant cells. There is no

clear reason for that to be in conflict with CRON's apparent effect

on lifespan.

Naturally, this is no more likely to be the right answer than any

other coming from anyone else equally as uninformed as I am.

But if it turned out to be the correct explanation then logically the

CRON practitioners with the highest body temperatures might be

expected to live the longest.

Rodney.

--- In , " Rodney " <perspect1111@y...>

wrote:

> Hi Don:

>

> I do not have any strong conviction about HOW this latest study

fits

> in with CRON.