Re: Using the VitaMix with CR (carrots)

[Guest guest]

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From: " jwwright " <jwwright@e...>

Date: Sun Jun 27, 2004 10:01 am

Subject: Re: Using the VitaMix with CR

I'm getting confused, Jeff. Let's suppose I use the vitamix to make a

v-8 juice? ( if that's possible) Am I concerned about GL or GI there?

I mean, if I eat a carrot, the GL is the same whether I grind it with

my teeth or grind it small. The BG might rise faster (MAYBE - depends

on the enzymes action and absorption), but in the end the amount of

insulin required is the same, right?

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The last question about whether the amount of insulin required

depends on the total amount of glucose and the rate of absorption is

very intriguing. I don't know the answer, but I have more questions.

It seems to me that eating very finely ground foods that are easily

absorbed would be equivalent to a Glucose Tolerance Test where you

take a big load of glucose at once. Eating coarsely ground food from

which all the glucose cannot be absorbed at once is more like an

intravenous glucose drip.

I have a feeling that there is a difference in metabolic stress

similar to the difference between running and walking. The amount of

calories burned are only slightly higher for running than for walking,

but you can walk a lot longer than you can run, and there is less

stress placed on the body when you walk (you don't even have to breath

hard).

I recall reading on this board postings from members who indicated

that they felt hypoglycemic shortly after eating. They attributed

this to the increase of insulin as a reaction to the food. I would

like to hypothesize that if these people ate more slowly (e.g., 1/5 of

their food every 10 minutes) they would have smaller insulin spikes

that would not cause hypoglycemia. These people should also stay away

from finely ground foods, smoothies, etc.

Running is an aerobic exercise that raises the heart rate above normal

resting levels and supposedly has some physiological benefits. Are

there any benefits to loading up on glucose to exercise the Islands of

Langerhans in the pancreas? Or will they last longer if you don't

stress them?

It seems to me that since diabetes is associated with chronic

carbohydrate overloads, it may be better to avoid glucose spikes by

not grinding food. What do you think?

Tony

[Guest guest]

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From: " Jeff Novick " <jnovick@p...>

Date: Sun Jun 27, 2004 5:37 pm

Subject: RE: [ ] Re: Using the VitaMix with CR (carrots)

This one has sometimes been called one of the " classics " . notice, that

though glucose levels didnt change much, insulin levels did. This is

overlooked in using just GI/GL

Lancet. 1977 Oct 1;2(8040):679-82.

Depletion and disruption of dietary fibre. Effects on satiety,

plasma-glucose,

and serum-insulin. ...

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At the risk of grinding this topic to death, I would like to raise

some additional questions about food administration and insulin

spikes. The article from Nature, below, indicates that life can be

extended when insulin-like signaling can be inhibited. This seems to

imply that the presence of insulin accelerates aging.

If the longevity achieved by caloric restriction is due to the

decrease of insulin in the blood, the following conclusions might be

possible:

1) Intermittent fasting without reduction of calories may indeed work

because on the fasting days there is no insulin in the blood. So, on

the day that you eat there is insulin in the blood and on the fasting

day there is none.

2) Caloric restriction works because the level of insulin in

constantly kept at low levels, thus preventing insulin-caused aging.

3) Eating regularly spaced meals may be a bad strategy for life

extension because the level of insulin would only drop to zero at

night.

4) The people who are eating only one meal a day, as mentioned by some

people in this group, may have a longevity advantage over those who

eat regularly spaced meals because insulin is completely depleted by

the time they take their next meal.

Does this make sense?

Tony

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Nature 429, 562 - 566 (03 June 2004); doi:10.1038/nature02549

Drosophila dFOXO controls lifespan and regulates insulin signalling in

brain and fat body

DAE SUNG HWANGBO, BORIS GERSHAM, MENG-PING TU, MICHAEL PALMER & MARC

TATAR

Division of Biology and Medicine, Box G-W, Brown University,

Providence, Rhode Island 02912, USA

Correspondence and requests for materials should be addressed to M.T.

(Marc_Tatar@...).

In Drosophila melanogaster, ageing is slowed when insulin-like

signalling is reduced: life expectancy is extended by more than 50%

when the insulin-like receptor (InR) or its receptor substrate (chico)

are mutated, or when insulin-producing cells are ablated. But we have

yet to resolve when insulin affects ageing, or whether insulin signals

regulate ageing directly or indirectly through secondary hormones.

Caenorhabditis elegans lifespan is also extended when insulin

signalling is inhibited in certain tissues, or when repressed in adult

worms, and this requires the forkhead transcription factor (FOXO)

encoded by daf-16 (ref. 6). The D. melanogaster insulin-like receptor

mediates phosphorylation of dFOXO, the equivalent of nematode daf-16

and mammalian FOXO3a. We demonstrate here that dFOXO regulates D.

melanogaster ageing when activated in the adult pericerebral fat body.

We further show that this limited activation of dFOXO reduces

expression of the Drosophila insulin-like peptide dilp-2 synthesized

in neurons, and represses endogenous insulin-dependent signalling in

peripheral fat body. These findings suggest that autonomous and

non-autonomous roles of insulin signalling combine to control ageing.