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Re: Soy Causes Intense Aggression & Submission in Males

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Hi Logan:

Gosh. That is STARTLING!!! And that is just the protein. I was

already not exactly enthusiastic about the fat.

Rodney.

> The study below seems to correlate with classic andropause symptoms.

>

> It's likely any defenciencies or increases occured in hormone

levels

> not analyzed.

>

> None of the behavioral changes are positive.

>

> Logan

>

>

> Increased aggressive behavior and decreased affiliative behavior in

> adult male monkeys after long-term consumption of diets rich in soy

> protein and isoflavones.

>

> Simon NG, Kaplan JR, Hu S, Register TC, MR.

> Department of Biological Sciences, Lehigh University, Bethlehem, PA

> 18015, USA.

> Horm Behav. 2004 Apr;45(4):278-84.

>

> Estrogen produced by aromatization of gonadal androgen has an

> important facilitative role in male-typical aggressive behavior

that

> is mediated through its interaction with estrogen receptors (ER) in

> the brain. Isoflavones found in soybeans and soy-based dietary

> supplements bind ER and have dose- and tissue-dependent effects on

> estrogen-mediated responses. Yet, effects of isoflavone-rich diets

on

> social and aggressive behavior have not been studied. We studied

the

> effects of long-term (15 months) consumption of diets rich in soy

> isoflavones on spontaneous social behavior among adult male

> cynomolgus macaques (Macaca fascicularis) (n = 44) living in nine

> stable social groups. There were three experimental conditions

which

> differed only by the source of dietary protein: casein and

> lactalbumin (no isoflavones), soy protein isolate containing 0.94

mg

> isoflavones/g protein, and soy protein isolate containing 1.88 mg

> isoflavones/g protein. In the monkeys fed the higher amount of

> isoflavones, frequencies of intense aggressive (67% higher) and

> submissive (203% higher) behavior were elevated relative to monkeys

> fed the control diet (P's < 0.05). In addition, the proportion of

> time spent by these monkeys in physical contact with other monkeys

> was reduced by 68%, time spent in proximity to other monkeys was

> reduced 50%, and time spent alone was increased 30% (P's < 0.02).

> There were no effects of treatment on serum testosterone or

estradiol

> concentrations or the response of plasma testosterone to exogenous

> gonadotropin-releasing hormone (GnRH). The results indicate that

long-

> term consumption of a diet rich in soy isoflavones can have marked

> influences on patterns of aggressive and social behavior.

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It's interesting that the researchers set out to investigate

the " effects on estrogen-mediated responses " but what they

found is:

" There were no effects of treatment on serum testosterone or

estradiol concentrations or the response of plasma testosterone to

exogenous gonadotropin-releasing hormone (GnRH). "

A possible mechanism for the increased aggressive behavior is that

the isoflavone genistein increases vasopressin. Increased

vasopressin increases aggressive behavior.

See:

Dietary exposure to genistein increases vasopressin but does not

alter beta-endorphin in the rat hypothalamus.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?

cmd=Retrieve & db=pubmed & dopt=Abstract & list_uids=12660364

http://snipurl.com/8g4d

And:

Vasopressin implicated in aggression

http://216.117.159.91/crimetimes/99a/w99ap9.htm

> > The study below seems to correlate with classic andropause

symptoms.

> >

> > It's likely any defenciencies or increases occured in hormone

> levels

> > not analyzed.

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