Resveratrol/NAD (was: Re: What is Caloric Restriction?)

[Guest guest]

Just some more stuff:

J Gerontol A Biol Sci Med Sci. 2004 Jun;59(6):B573-8.

"Anti-aging" is an oxymoron.Hayflick L.Professor of Anatomy, Department of Anatomy, University of California, San Francisco, School of Medicine, P.O. Box 89, The Sea Ranch, CA 95497, USA. len@...No intervention will slow, stop, or reverse the aging process in humans. Whether anti-aging medicine is, or is not, a legitimate science is completely dependent upon the definition of key terms that define the finitude of life: longevity determination, aging, and age-associated diseases. Only intervention in the latter by humans has been shown to affect life expectancy. When it becomes possible to slow, stop, or reverse the aging process in the simpler molecules that compose inanimate objects, such as machines, then that prospect may become tenable for the complex molecules that compose life forms. Most of the resources available under the rubric "aging research" are not used for that purpose at all, thus making the likelihood of intervention in the process even more remote. If age changes are the greatest risk factor for age-associated diseases (an almost universal belief), then why is the study of aging virtually neglected?PMID: 15215267

[Guest guest]

I might choose another term for Hayflick's pronouncements.

>From: " jwwright " <jwwright@...>

>Reply-

>< >

>Subject: Re: [ ] Resveratrol/NAD (was: Re: What is Caloric

>Restriction?)

>Date: Tue, 3 Aug 2004 12:49:33 -0500

>

>Just some more stuff:

>

> J Gerontol A Biol Sci Med Sci. 2004 Jun;59(6):B573-8.

>

>

> " Anti-aging " is an oxymoron.

>

>Hayflick L.

>

>Professor of Anatomy, Department of Anatomy, University of California, San

>Francisco, School of Medicine, P.O. Box 89, The Sea Ranch, CA 95497, USA.

>len@...

>

>No intervention will slow, stop, or reverse the aging process in humans.

>Whether anti-aging medicine is, or is not, a legitimate science is

>completely dependent upon the definition of key terms that define the

>finitude of life: longevity determination, aging, and age-associated

>diseases. Only intervention in the latter by humans has been shown to

>affect life expectancy. When it becomes possible to slow, stop, or reverse

>the aging process in the simpler molecules that compose inanimate objects,

>such as machines, then that prospect may become tenable for the complex

>molecules that compose life forms. Most of the resources available under

>the rubric " aging research " are not used for that purpose at all, thus

>making the likelihood of intervention in the process even more remote. If

>age changes are the greatest risk factor for age-associated diseases (an

>almost universal belief), then why is the study of aging virtually

>neglected?

>

>PMID: 15215267

[Guest guest]

Rapid reversion of aging phenotypes by nicotinamide through possible

modulation of histone acetylation.

Matuoka K, Chen KY, Takenawa T.

Institute of Medical Science, University of Tokyo, Japan.

kmatuoka@...

Cell Mol Life Sci. 2001 Dec;58(14):2108-16.

Aging appears to be an irreversible process. Here we report that

nicotinamide (NAA) can induce rapid and reversible reversion of aging

phenotypes in human diploid fibroblasts in terms of cell morphology

and senescence-associated beta-galactosidase activity. Although NAA

seems to enhance the replicative potential of the cells, it has

little effect on their growth rate and life span, suggesting that NAA

action is rather separated from the cellular replicative system. The

effects are unique to NAA: none ofthe NAA-related compounds examined

(an NAD precursor/niacin, NAD analogs, and poly(ADP-ribose)

polymerase inhibitors) exerted similar effects. Thus, NAD-related

metabolism and poly(ADP-ribosyl)ation are unlikely related to the NAA

action. On the other hand, histone acetyltransferase (HAT) activity

was elevated in NAA-exposed cells, while in aged cells, HAT activity

and histone H4 acetylation were lowered. Taken together, the results

suggest that NAA may cause rejuvenation by restoring, at least in

part, altered gene expression in aged cells through its activation of

HAT.

Logan

>

> >

> > There is also some evidence NAD resets the Hayflick limit.

> >

> > Logan

> >