RE: Re: Type II Diabetes & CRON & insulin

[Guest guest]

As long as we're on a insulin pathway theme, meal spacing or rather a small

number of larger feedings vs. snacking or grazing may not affect total or

average exposure to insulin but may increase the quiet periods where you are

not exposed to elevated insulin, which improves insulin sensitivity and

reduces amount of insulin required to manage BG.

FWIW, I don't know how strong the evidence is for insulin as a malefactor

but CR however practiced does appear to reduce total insulin exposure so

there may be some complementary relationships to energy restriction.

JR

-----Original Message-----

From: Rodney [mailto:perspect1111@...]

Sent: Thursday, July 08, 2004 8:52 AM

Subject: [ ] Re: Type II Diabetes & CRON

Hi JR:

That is VERY well stated!

So I should modify my position to asking whether studies have been

done to determine if there is any preference as to the source of the

incremental calories consumed, above those required for satisfying

the essential macronutrient minimum requirements.

Perhaps for those on a CR diet it will make no difference (perhaps

not?). But my guess is that there may be a major preference for

those whose daily caloric intake is in line with the amounts

generally recommended by governmental authorities (3000 kcal/day, for

example).

Either way, it would be nice to know. It would also be nice to have

a definitive answer to the meal spacing issue. Lee is only one

mouse. But his data are highly suggestive. I believe some results

are due soon from a meal spacing study on mice.

Rodney.

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