RE: Re: Vitamin E types and prostate

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>From: " Rodney " <perspect1111@...>

>Reply-

>

>Subject: [ ] Re: Vitamin E types and prostate

>Date: Tue, 10 Aug 2004 12:04:43 -0000

>

>Hi folks:

>

>Can someone tell me ............ are the differences between the

>different forms of vitamin E simply that they are isomers? Or are

>the differences more fundamental than that? TIA.

>

>Rodney.

>

>

> > J Natl Cancer Inst. 2000 Dec 20;92(24):2018-23. Related Articles,

> > Links

> >

> >

> > Comment in:

> > J Natl Cancer Inst. 2000 Dec 20;92(24):1966-7.

> >

> > Association between alpha-tocopherol, gamma-tocopherol, selenium,

>and

> > subsequent prostate cancer.

> >

> > Helzlsouer KJ, Huang HY, Alberg AJ, Hoffman S, Burke A, Norkus EP,

> > JS, Comstock GW.

> >

> > Department of Epidemiology, The s Hopkins School of Hygiene and

> > Public Health, Baltimore, MD 21205, USA. Khelzlso@j...

> >

> > BACKGROUND: Selenium and alpha-tocopherol, the major form of

>vitamin

> > E in supplements, appear to have a protective effect against

>prostate

> > cancer. However, little attention has been paid to the possible

>role

> > of gamma-tocopherol, a major component of vitamin E in the U.S.

>diet

> > and the second most common tocopherol in human serum. A nested case-

> > control study was conducted to examine the associations of alpha-

> > tocopherol, gamma-tocopherol, and selenium with incident prostate

> > cancer. METHODS: In 1989, a total of 10,456 male residents of

> > Washington County, MD, donated blood for a specimen bank. A total

>of

> > 117 of 145 men who developed prostate cancer and 233 matched

>control

> > subjects had toenail and plasma samples available for assays of

> > selenium, alpha-tocopherol, and gamma-tocopherol. The association

> > between the micronutrient concentrations and the development of

> > prostate cancer was assessed by conditional logistic regression

> > analysis. All statistical tests were two-sided. RESULTS: The risk

>of

> > prostate cancer declined, but not linearly, with increasing

> > concentrations of alpha-tocopherol (odds ratio (highest versus

>lowest

> > fifth) = 0.65; 95% confidence interval = 0.32--1.32; P(trend)

>=.28).

> > For gamma-tocopherol, men in the highest fifth of the distribution

> > had a fivefold reduction in the risk of developing prostate cancer

> > than men in the lowest fifth (P:(trend) =.002). The association

> > between selenium and prostate cancer risk was in the protective

> > direction with individuals in the top four fifths of the

>distribution

> > having a reduced risk of prostate cancer compared with individuals

>in

> > the bottom fifth (P(trend) =.27). Statistically significant

> > protective associations for high levels of selenium and alpha-

> > tocopherol were observed only when gamma-tocopherol concentrations

> > were high. CONCLUSIONS: The use of combined alpha- and gamma-

> > tocopherol supplements should be considered in upcoming prostate

> > cancer prevention trials, given the observed interaction between

> > alpha-tocopherol, gamma-tocopherol, and selenium.

> >

> > PMID: 11121464 [PubMed - indexed for MEDLINE]

>