Re: Vitamin E types and prostate

[Guest guest]

> J Natl Cancer Inst. 2000 Dec 20;92(24):2018-23. > J Natl Cancer

Inst. 2000 Dec 20;92(24):1966-7.

> Association between alpha-tocopherol, gamma-tocopherol, selenium,

and > subsequent prostate cancer.>

> Helzlsouer KJ, Huang HY, Alberg AJ, Hoffman S, Burke A, Norkus EP,

> JS, Comstock GW.

> PMID: 11121464 [PubMed - indexed for MEDLINE]

Hi All,

Which maybe why http://tinyurl.com/6mlxn found no association for

cardiovascular disease risk of the vitamin.

Cheers, Al Pater.

[Guest guest]

Hi Al:

Could you please elaborate a bit on that response of yours? Are you

saying the reason no effect was found may have been because no gamma-

tocopherol was used in the study? Or are you saying something else?

TIA

Rodney.

>

> > J Natl Cancer Inst. 2000 Dec 20;92(24):2018-23. > J Natl Cancer

> Inst. 2000 Dec 20;92(24):1966-7.

> > Association between alpha-tocopherol, gamma-tocopherol, selenium,

> and > subsequent prostate cancer.>

> > Helzlsouer KJ, Huang HY, Alberg AJ, Hoffman S, Burke A, Norkus

EP,

> > JS, Comstock GW.

> > PMID: 11121464 [PubMed - indexed for MEDLINE]

>

> Hi All,

>

> Which maybe why http://tinyurl.com/6mlxn found no association for

> cardiovascular disease risk of the vitamin.

>

> Cheers, Al Pater.

[Guest guest]

Hi All,

Yes, ROdney the reason no effect was found may have been because no

gamma-tocopherol was used in the study.

Cheers, Al Pater.

> >

> > > J Natl Cancer Inst. 2000 Dec 20;92(24):2018-23. > J Natl

Cancer

> > Inst. 2000 Dec 20;92(24):1966-7.

> > > Association between alpha-tocopherol, gamma-tocopherol,

selenium,

> > and > subsequent prostate cancer.>

> > > Helzlsouer KJ, Huang HY, Alberg AJ, Hoffman S, Burke A, Norkus

> EP,

> > > JS, Comstock GW.

> > > PMID: 11121464 [PubMed - indexed for MEDLINE]

> >

> > Hi All,

> >

> > Which maybe why http://tinyurl.com/6mlxn found no association for

> > cardiovascular disease risk of the vitamin.

> >

> > Cheers, Al Pater.

[Guest guest]

Hi folks:

Can someone tell me ............ are the differences between the

different forms of vitamin E simply that they are isomers? Or are

the differences more fundamental than that? TIA.

Rodney.

> J Natl Cancer Inst. 2000 Dec 20;92(24):2018-23. Related Articles,

> Links

>

>

> Comment in:

> J Natl Cancer Inst. 2000 Dec 20;92(24):1966-7.

>

> Association between alpha-tocopherol, gamma-tocopherol, selenium,

and

> subsequent prostate cancer.

>

> Helzlsouer KJ, Huang HY, Alberg AJ, Hoffman S, Burke A, Norkus EP,

> JS, Comstock GW.

>

> Department of Epidemiology, The s Hopkins School of Hygiene and

> Public Health, Baltimore, MD 21205, USA. Khelzlso@j...

>

> BACKGROUND: Selenium and alpha-tocopherol, the major form of

vitamin

> E in supplements, appear to have a protective effect against

prostate

> cancer. However, little attention has been paid to the possible

role

> of gamma-tocopherol, a major component of vitamin E in the U.S.

diet

> and the second most common tocopherol in human serum. A nested case-

> control study was conducted to examine the associations of alpha-

> tocopherol, gamma-tocopherol, and selenium with incident prostate

> cancer. METHODS: In 1989, a total of 10,456 male residents of

> Washington County, MD, donated blood for a specimen bank. A total

of

> 117 of 145 men who developed prostate cancer and 233 matched

control

> subjects had toenail and plasma samples available for assays of

> selenium, alpha-tocopherol, and gamma-tocopherol. The association

> between the micronutrient concentrations and the development of

> prostate cancer was assessed by conditional logistic regression

> analysis. All statistical tests were two-sided. RESULTS: The risk

of

> prostate cancer declined, but not linearly, with increasing

> concentrations of alpha-tocopherol (odds ratio (highest versus

lowest

> fifth) = 0.65; 95% confidence interval = 0.32--1.32; P(trend)

=.28).

> For gamma-tocopherol, men in the highest fifth of the distribution

> had a fivefold reduction in the risk of developing prostate cancer

> than men in the lowest fifth (P:(trend) =.002). The association

> between selenium and prostate cancer risk was in the protective

> direction with individuals in the top four fifths of the

distribution

> having a reduced risk of prostate cancer compared with individuals

in

> the bottom fifth (P(trend) =.27). Statistically significant

> protective associations for high levels of selenium and alpha-

> tocopherol were observed only when gamma-tocopherol concentrations

> were high. CONCLUSIONS: The use of combined alpha- and gamma-

> tocopherol supplements should be considered in upcoming prostate

> cancer prevention trials, given the observed interaction between

> alpha-tocopherol, gamma-tocopherol, and selenium.

>

> PMID: 11121464 [PubMed - indexed for MEDLINE]

[Guest guest]

Hi All,

Yes, Rodney. See:

Ann Nutr Metab. 2004 Jul 12;48(3):169-188.

Gamma-Tocopherol - An Underestimated Vitamin?

Wagner KH, Kamal-Eldin A, Elmadfa I.

The main research activities of the last decades on tocopherols were

mainly focused on alpha-tocopherol, in particular when considering

the biological activities. However, recent studies have increased the

knowledge on gamma-tocopherol, which is the major form of vitamin E

in the diet in the USA, but not in Europe. gamma-Tocopherol provides

different antioxidant activities in food and in-vitro studies and

showed higher activity in trapping lipophilic electrophiles and

reactive nitrogen and oxygen species. The lower plasma levels of

gamma- compared to alpha-tocopherol might be discussed in the light

of different bioavailability, but also in a potential transformation

from gamma- into alpha-tocopherol. From the metabolism end product,

only that of gamma-tocopherol (2,7,8-trimethyl-2-(beta-carboxyethyl)-

6-hydroxychroman), but not that of alpha-tocopherol, was identified

to provide natriuretic activity. Studies also indicate that only the

gamma-tocopherol plasma level served as biomarker for cancer and

cardiovascular risk. in food, different intake linking to different

plasma levels inTherefore, this paper provides a comprehensive review

on gamma-tocopherol with emphasis on its chemistry, biosynthesis,

occurrence USA and Europe, absorption and metabolism, biological

activities, and possible role in human health.

PMID: 15256801 [PubMed - as supplied by publisher]

> > J Natl Cancer Inst. 2000 Dec 20;92(24):2018-23. > >

> > Association between alpha-tocopherol, gamma-tocopherol, selenium,

> and

> > subsequent prostate cancer.

> > Helzlsouer KJ, Huang HY, Alberg AJ, Hoffman S, Burke A, Norkus

EP,

> > JS, Comstock GW.> >

> > PMID: 11121464 [PubMed - indexed for MEDLINE]