Re: Soy - Prostate Cancer and Baldness

[Guest guest]

I like messing with my androgens a lot less than my baldness.

CR is still about eating less calories.

Regards.

----- Original Message -----

From:

Sent: Sunday, July 18, 2004 12:00 AM

Subject: [ ] Soy - Prostate Cancer and Baldness

According to this study equol prevents the hormone dihydrotestosterone from stimulating prostate growth and causing baldness. If this is true real men are going to start eating soy by the scoopfuls (if they don't already). I fearlessly eat itbecause it was generally recognized as safe by the Okinawins.

[Guest guest]

Hi :

It may, possibly, matter which part(s) of the bean you eat, and which

parts you avoid. Do we know whether equol comes accompanied by the

fat, or by the protein?

Rodney.

> According to this study equol prevents the hormone

> dihydrotestosterone from stimulating prostate growth and causing

> baldness. If this is true real men are going to start eating soy by

> the scoopfuls (if they don't already). I fearlessly eat it

> because it was generally recognized as safe by the Okinawins.

>

>

>

> http://www.biolreprod.org/cgi/content/abstract/70/4/1188

>

> Equol Is a Novel Anti-Androgen that Inhibits Prostate Growth and

> Hormone Feedback1

> Trent D. Lund2,3, J. Munson3, E. Haldy3, D.R.

> Setchell4, Edwin D. Lephart5 and J. Handa3

> Department of Biomedical Sciences,3 Colorado State University, Fort

> , Colorado 80524 Clinical Mass Spectrometry,4 Children's

> Hospital Medical Center, Cincinnati, Ohio 45229 The Neuroscience

> Center and Department of Physiology and Developmental Biology,5

> Brigham Young University, Provo, Utah 84602

> Equol (7-hydroxy-3[4'hydroxyphenyl]-chroman) is the major

metabolite

> of the phytoestrogen daidzein, one of the main isoflavones found

> abundantly in soybeans and soy foods. Equol may be an important

> biologically active molecule based on recent studies demonstrating

> that equol can modulate reproductive function. In this study, we

> examined the effects of equol on prostate growth and LH secretion

> and determined some of the mechanisms by which it might act.

> Administration of equol to intact male rats for 4–7 days reduced

> ventral prostate and epididymal weight and increased circulating LH

> levels. Using binding assays, we determined that equol specifically

> binds 5 -dihydrotestosterone (DHT), but not testosterone,

> dehydroepiandrosterone, or estrogen with high affinity. Equol does

> not bind the prostatic androgen receptor, and has a modest affinity

> for recombinant estrogen receptor (ER) ß, and no affinity for ER .

> In castrated male rats treated with DHT, concomitant treatment with

> equol blocked DHT's trophic effects on the ventral prostate gland

> growth and inhibitory feedback effects on plasma LH levels without

> changes in circulating DHT. Therefore, equol can bind circulating

> DHT and sequester it from the androgen receptor, thus altering

> growth and physiological hormone responses that are regulated by

> androgens. These data suggest a novel model to explain equol's

> biological properties. The significance of equol's ability to

> specifically bind and sequester DHT from the androgen receptor have

> important ramifications in health and disease and may indicate a

> broad and important usage for equol in the treatment of androgen-

> mediated pathologies.

> 1 Supported in part by NIH grants AA12693 and NS39951 (R.J.H.) and

> USDA grant 2002-00798 (E.D.L.).

> 2 Correspondence: Trent D. Lund, Department of Biomedical Science,

> Colorado State University, Anatomy W103, 1617 Campus Delivery, Ft.

> , CO 80523-1670. FAX: 970 491 7907; tlund@c...

[Guest guest]

An excellent find, Rodney, and hi All,

But, more than that, see the below which seems to say that us North

Americans have the deck stacked against us.

Cheers, Al Pater.

Jpn J Clin Oncol. 2004 Feb;34(2):86-9.

Comparisons of percent equol producers between prostate cancer

patients and controls: case-controlled studies of isoflavones in

Japanese, Korean and American residents.

BACKGROUND: Our previous case-control study revealed that the

Japanese residents in Japan could be divided into those who are able

to degrade daidzein, a soybean isoflavone, to equol and those without

this ability, and that the incidence of prostate cancer is higher in

the latter group. METHODS: We .... The incidence of prostate cancer

in Korean residents is known to be close to that of Japanese

residents in Japan. On the other hand, American residents in the

United States have a markedly higher incidence of prostate cancer as

compared to Japanese residents in Japan. RESULTS: The number of

subjects was 295 in Japan (133 patients and 162 controls), 122 in

Korea (61 patients and 61 controls) and 45 in the United States (24

patients and 21 controls). The percentage of equol producers among

patients and controls was 29% and 46% in Japan (P = 0.004) and 30%

and 59% in Korea (P = 0.001), respectively. The active isoflavone

level was markedly lower and the percentage of equol producers was

also lower (17% for patients and 14% for controls) for Americans as

compared to the Japanese and Koreans. CONCLUSIONS: These results

suggest that the ability of producing equol or equol itself is

closely related to the lower incidence of prostate cancer. The

results also suggest that a diet based on soybean isoflavones will be

useful in preventing prostate cancer.

PMID: 15067102 [PubMed - indexed for MEDLINE]

> Equol is a metabolite of daidzen, a major isoflavone in soy. It's

probably

> present in fair quantity in most soy products:

>

> " In addition to whole soybeans, foods derived from soy include

tofu, tempeh,

> soymilk, textured and hydrolyzed vegetable protein, meat

substitutes, soy

> flour, miso, and soy sauce. Soy is also available as a supplement,

as soy

> protein or isoflavone in powder, capsule, or tablet form. High

levels of

> soy-based isoflavones are in roasted soy nuts, tofu, tempeh,

soymilk, and

> some soy protein isolates. "

>

> Also, note green tea and soy synergy:

>

> Asian Pac J Cancer Prev. 2003 Aug-Dec;4(4):297-301. Related

Articles, Links

>

>

> Higher consumption of green tea may enhance equol production.

>

> Miyanaga N, Akaza H, Takashima N, Nagata Y, Sonoda T, Mori M, Naito

S, Hirao

> Y, Tsukamoto T, Fujioka T.

>

> BACKGROUND: Our previous case-control study revealed that Japanese

living in

> Japan and Koreans living in Korea can be divided into equol

producers who

> have an ability to metabolize daidzein to equol and non-producers,

and that

> the incidence of prostate cancer is higher in the latter

group. .... RESULTS: The frequency of

> equol producers (0.5 ng/ml or more) among cases and controls was

29% and

> 45%, respectively (p = 0.004). The consumption of soybeans and

green tea

> were significantly higher in equol producers than in the non-

producers

> (p<0.05). By contrast, the consumption of selenium and fiber was

> significantly lower in equol producers (p<0.05). CONCLUSIONS: Our

results

> suggest that higher consumption of soybean and green tea are

strongly

> related to the establishment of a capacity for equol production.

>

> PMID: 14728586 [PubMed - indexed for MEDLINE]

[Guest guest]

Hi JW:

A couple of months ago here someone (Dennis, perhaps?) credited

(purely anecdotally) a sizeable improvement in his PSA score to the

addition of soy protein to his diet. He did not report any other

phenomena of the type Logan mentioned. But I don't know how much

Dennis was taking. At least it doesn't contain (as much?) ALA!

I agree with those who think it may be appropriate to be cautious

regarding soy products, given the highly contradictory views held by

apparently reputable sources on both sides of the issue.

Rodney.

--- In , " jwwright " <jwwright@e...>

wrote:

> Thanks, ,

> That means about 1 oz of SPI (I guess it's really a concentrate

because it's about 98% protein), for a 135 # person. For 110 kcals.

>

> I can do that. (until I forget to do it (ha)).

>

> I've used SPI© in the past to get enough Pro with a veggie diet.

May be a good trade off with milk for a while. I can see if it

effects the BPH or PSA.

> I know nothing else with claimed effects has changed anything so

far. The isoflavone pills do nothing.

>

> That's for

> ----- Original Message -----

> From: scott@e...

>

> Sent: Monday, July 19, 2004 4:27 PM

> Subject: RE: [ ] Re: Soy - Prostate Cancer and

Baldness

>

>

> Urinary isoflavone kinetics: the effect of age, gender, food

matrix and chemical composition.

>

>

>

> This study (April '04) used 0.44 mg isoflavones/kg body weight.

>

>

>

> Conclusion:

>

> Together these data suggest that the fractional absorption of

genistein is potentially different in men and women and is influenced

by the food matrix and chemical composition. Furthermore, the data

suggest that the metabolism of daidzein may be altered by the

chemical composition of the isoflavones ingested. Further studies are

required to examine the effect of higher intake and define the

relative influence of these factors in elderly population groups (my

emphasis).

>

>

>

> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?

cmd=Retrieve & db=pubmed & dopt=Abstract & list_uids=15035683

>

>

>

> http://snipurl.com/7v8x

>

>

>

>

>

>

>

> -------- Original Message --------

> Subject: Re: [ ] Re: Soy - Prostate Cancer and

Baldness

> From: " jwwright " jwwright@e...

>

>

>

> So all that sounds like it wouldn't make much diff if they were

equol producers or not, right? If we don't make equol, we'd need a

pill. If we do make it we'd need to eat soy,

>

> The next question is how much do we eat? Regards.

[Guest guest]

Hi All,

The 20% isoflavone-rich soy protein isolate (SPI) seems inordinately

high.

PMID: 12518321 [PubMed - indexed for MEDLINE]

--- In , " jwwright " <jwwright@e...>

wrote:

> Thanks, ,

> That means about 1 oz of SPI (I guess it's really a concentrate

because it's about 98% protein), for a 135 # person. For 110 kcals.

>

> I can do that. (until I forget to do it (ha)).

>

> I've used SPI© in the past to get enough Pro with a veggie diet.

May be a good trade off with milk for a while. I can see if it

effects the BPH or PSA.

> I know nothing else with claimed effects has changed anything so

far. The isoflavone pills do nothing.