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" This contradiction raised the possibility that calorie restriction

operates through another mechanism, independent of SIR2. In support

of this view, caloric restriction enhances life span to a greater

extent in FOB1 mutants lacking SIR2 than in FOB1 mutants with an

intact SIR2 gene. This and other genetic experiments indicate that

calorie restriction does not always work through SIR2. "

http://tinyurl.com/3pdkr

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