Re: Re: More on Vitamin D Deficiencies

[Guest guest]

Thanks, Rodney-

Vit. D appears to be a bit of a " wonder " nutrient!

>From: " Rodney " <perspect1111@...>

>Reply-

>

>Subject: [ ] Re: More on Vitamin D Deficiencies

>Date: Sat, 07 Aug 2004 21:17:17 -0000

>

>Hi :

>

>SCIENTISTS CALL FOR CALCIUM, VITAMIN D FORTIFICATION

>

>http://www.nutraingredients-usa.com/news/news-NG.asp?id=53839

>

>http://snipurl.com/8anj

>

>Rodney.

>

>

> > Wery interesting!

> >

> > Something is definitely going on with vitamin D! After reading the

>WebMD

> > article you've linked, I just added a few thousand IUs to my 2,000

>IU daily

> > supplements of D.

> >

> > Another interesting study:

> >

> > Eur J Endocrinol. 2004 Aug;151(2):167-72. Related Articles, Links

> >

> >

> > Serum parathyroid hormone level is associated with body mass index.

>The 5th

> > Tromso study.

> >

> > Kamycheva E, Sundsfjord J, Jorde R.

> >

> > Department of Internal Medicine, University Hospital of North

>Norway,

> > N-9038, Tromso, Norway.

> >

> > OBJECTIVE: To study whether serum parathyroid hormone (PTH) and

>serum

> > calcium are associated with body mass index (BMI), and their

>predicting role

> > in obesity. DESIGN: Population based, cross-sectional study.

>METHODS: In

> > 2001 a population-based health survey was held in Tromso, North

>Norway.

> > Questionnaires on medical history and life-style factors were

>completed and

> > anthropometric data were collected. Calcium and vitamin D intakes

>and a

> > physical activity score were calculated. Serum calcium and PTH were

>measured

> > in a subset of 3447 men and 4507 women. Pearson correlation and

>linear

> > regression were used to evaluate associations between BMI, PTH and

>serum

> > calcium, and logistic regression was used to test PTH and serum

>calcium as

> > predictors of obesity and to calculate odds ratio. Relative risk

>was

> > calculated using frequency tables. RESULTS: For serum calcium and

>PTH there

> > was a significant positive relation to BMI in both genders

>(P<0.001), which

> > to our knowledge has not previously been reported on the basis of a

>large

> > epidemiological study. Age, low calcium and vitamin D intakes were

> > explanatory variables for serum PTH. The highest quartile of serum

>PTH

> > (>4.20 pmol/l) was a significant predictor for obesity (P<0.001) in

>both

> > genders, adjusted for age, physical activity and serum calcium.

>Obesity

> > rates were higher in those with PTH levels in the highest quartile

>compared

> > with those in the lower quartiles, which resulted in a relative

>risk of 1.40

> > (95% confidence interval (C.I.) 1.20-1.60) for men and 1.48 (95%

>C.I.

> > 1.31-1.67) for women. CONCLUSIONS: Serum PTH, adjusted for age,

>physical

> > activity and serum calcium, is positively associated with BMI in

>both sexes,

> > and serum PTH is an independent predictor of obesity in our

>statistical

> > model.

> >

> > PMID: 15296470 [PubMed - in process]

> >

> >

> >

> > >From: " Rodney " <perspect1111@y...>

> > >Reply-

> > >

> > >Subject: [ ] More on Vitamin D Deficiencies

> > >Date: Sat, 07 Aug 2004 20:50:29 -0000

> > >

> > >Hi folks:

> > >

> > > " The Institute of Medicine recommends 200 IU a day up to the age of

> > >50, 400 IU from 51 to 70, and 600 IU over age 70. About 100 IU are

> > >found in an 8 ounce glass of fortified milk. Other nutritional

> > >sources of Vitamin D include:

> > >

> > >

> > >Canned pink salmon: 3 ounces contain about 530 IU of Vitamin D

> > >

> > >Canned sardines: 3 ounces contain about 231 IU of Vitamin D

> > >

> > >Fortified orange juice: 8 ounces contain about 100 IU of vitamin D

> > >

> > >Fortified cereal: 1 serving (about 1 cup) contains about 40-50 IU

>of

> > >vitamin D "

> > >

> > >http://my.webmd.com/content/article/91/101374.htm

> > >

> > >Rodney.

> > >

> > >

> > >

>

[Guest guest]

I'm not sure I'd call Vit D a wonder nutrient, but as with all vitamins they

are essential and any deficiency will not be good. It is (they are) fat

soluble so our body saves excess created/ingested in our fat cells to help

us through cloudy days and things like winter :-). As with all fat soluble

Vits there is such a thing as too much so don't go nuts with supplements

especially for those of us north of the equator in summer.

I wouldn't attempt to characterize a single significant function, D appears

to have a hand in many important mechanisms (bone health, hormone

generation, etc).

Anyone feeling low on Vit D is welcome to come mow my lawn. Down here in

central MS, that should give you a decent dose....

As much fun as it is to bash the gov't, programs like adding vit D to milk

have been beneficial to the general population. I suspect those of us eating

outside the " enriched foods " mainstream, need to be alert for deficiencies

that would be rare in those eating their wonder bread and special K.....

Have you ever thought about why they iodized salt, or enriched flour?

JR

PS: I find myself having to supplement salt... not exactly a risk factor for

the masses :-)

-----Original Message-----

From: Dowling [mailto:dowlic@...]

Sent: Saturday, August 07, 2004 5:31 PM

Subject: RE: [ ] Re: More on Vitamin D Deficiencies

Thanks, Rodney-

Vit. D appears to be a bit of a " wonder " nutrient!

>From: " Rodney " <perspect1111@...>

>Reply-

>

>Subject: [ ] Re: More on Vitamin D Deficiencies

>Date: Sat, 07 Aug 2004 21:17:17 -0000

>

>Hi :

>

>SCIENTISTS CALL FOR CALCIUM, VITAMIN D FORTIFICATION

>

>

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[Guest guest]

FYI.

Ford: Clinical Toxicology, 1st ed., Copyright © 2001 W. B. Saunders Company

Pathophysiology

Hypervitaminosis D can result from excessive vitamin D dietary supplementation,[24] inaccurately and excessively fortified dairy products,[28] prolonged use of vitamin D–fortified infant formulas,[39] or ingestion of vitamin D rodenticides. Iatrogenic hypervitaminosis D is seen in poorly monitored vitamin D therapy for disorders such as rickets and hypoparathyroidism.[26] [51] The toxic manifestations are due to hypercalcemia.

24. Hirano T, Janakiraman N, Rosenthal IM: Vitaminosis D poisoning from ingestion of concentrated vitamin D used to fortify milk. Ill Med J 1977; 151:418–420.

Clinical Presentation

Although hypervitaminosis D may present acutely, it usually presents with the insidious onset of symptoms of hypercalcemia ( Table 34–6 ). The diagnosis requires a high index of suspicion of excessive vitamin D intake as the cause of unexplained hypercalcemia. Patients’ complaints may seem somewhat diffuse due to the many organ systems affected. Signs and symptoms may involve any combination of the gastrointestinal, musculoskeletal, cardiovascular, renal, and central nervous systems. Patients with vitamin D toxicity and significant hypercalcemia may have bone pain, polyuria, polydipsia, and ectopic soft tissue calcifications, including nephrocalcinosis and corneal calcifications. Children, especially infants, may present primarily with irritability, failure to thrive, nausea, and vomiting. Patients may also have pancreatitis, progressive renal failure, and, rarely, hypercalcemia-induced cardiac dysrhythmias.[24] [26] [28] [45] [51]

TABLE 34-6 -- Clinical Presentation of Hypervitaminosis D

System

Adult

Pediatric

Neurologic

Headache

Headache

Confusion

Irritability

Gastrointestinal

Anorexia

Anorexia

Nausea

Nausea

Vomiting

Vomiting

Abdominal pain

Abdominal pain

Pancreatitis (rare)

Musculoskeletal

Bone pain

Bone pain

Cardiovascular

Dysrhythmias (rare)

Hypertension

Renal

Polyuria

Renal failure (rare)

Other

Weakness/fatigue

Weakness/fatigue

Weight loss

Weight loss

Polydipsia

Failure to thrive

Treatment

Initial management is the withdrawal of all exogenous sources of vitamin D and a low-calcium, low-vitamin D diet. Treatment of hypercalcemia includes intravenous fluid hydration and monitoring of renal function. Furosemide may increase renal calcium excretion. Glucocorticoids have been effective in reducing serum calcium levels, although the primary mechanism is unclear.[27] [55] Bisphosphonate inhibitors of bone resorption have also been used to treat hypercalcemia due to hypervitaminosis D[45] [51] (see Table 34–8 ).

{Hard to see the mechanism of too much D though since it must be converted in the liver, unless it's calcitriol?}

Regards.

----- Original Message -----

From: citpeks

Sent: Saturday, August 07, 2004 11:34 PM

Subject: [ ] Re: More on Vitamin D Deficiencies

>>>>From: "john roberts" <johnhrob@n...>Date: Sat Aug 7, 2004 10:04 pmSubject: Re: More on Vitamin D Deficiencies...Anyone feeling low on Vit D is welcome to come mow my lawn. Down herein central MS, that should give you a decent dose>>>>The book "The Protein Power Lifeplan" by Dr. Micheal Eades and Dr. Eades dedicates one chapter to the issue of Vitamin D andsunlight exposure. Here are some interesting points:P. 231: When sunlight strikes exposed skin, the UVB portion causes achemical change in a special type of cholesterol present in the skin,converting it to an inactive precursor of vitamin D. In the liverthis precursor is changed by hydroxylation, ... and finally it ischanged by the kidney into active vitamin D.P. 233: But couldn't I just take vitamin D pills? p.234 ... thatchoice is fraught with some risk since in excess, dietary vitamin D isquite toxic, as the British discovered in the 1950s when they soughtto ensure adequate levels of it by adding it to much of their foodsupply. Instead of making a healthier population, they ended upcreating an epidemic of vitamin D-toxicity syndrome ...p. 234: Research has shown that ... to produce the minium dailyrequirement of 400 IU would demand a mere 20 [square] centimeters ofexposed skin, or about the size of the cheeks of toddler, even bundledup on a cold winter's day. [3 hour exposure]===From the Merck Manualhttp://www.merck.com/mrkshared/mmanual/section1/chapter3/3e.jspVitamin D ToxicityVitamin D 1000 µg (40,000 IU)/day produces toxicity within 1 to 4moin infants, and as little as 75 µg (3000 IU)/day can producetoxicityover years. Toxic effects have occurred in adults receiving 2500 µg(100,000 IU)/day for several months. Elevated serum calcium levels of12 to 16 mg/dL (3 to 4 mmol/L) are a constant finding when toxicsymptoms occur; normal levels are 8.5 to 10.5 mg/dL (2.12 to 2.62mmol/L). Serum calcium should be measured frequently (weekly at first,then monthly) in all patients receiving large doses of vitamin D.The first symptoms are anorexia, nausea, and vomiting, followed bypolyuria, polydipsia, weakness, nervousness, and pruritus. Renalfunction is impaired, as evidenced by low sp gr urine, proteinuria,casts, and azotemia. Metastatic calcifications may occur, particularlyin the kidneys. Plasma 25(OH)D3 levels are elevated as much asfifteenfold in vitamin D toxicity, whereas 1,25(OH)2D3 levels areusually within the normal range.A history of excessive vitamin D intake is critical fordifferentiating this condition from all other hypercalcemic states.Vitamin D toxicity occurs commonly during the treatment ofhypoparathyroidism (see Hypocalcemia under Disorders of CalciumMetabolism in Ch. 12) and with the misguided use of megavitamins. InGreat Britain, so-called hypercalcemia in infancy with failure tothrive has occurred with a daily vitamin D intake of 50 to 75 µg(2000to 3000 IU). syndrome consists of transient hypercalcemia ininfancy with the triad of supravalvular aortic stenosis, mentalretardation, and elfin facies. Plasma levels of 1,25(OH)2D3 during thehypercalcemic phase are 8 to 10 times normal. Most cases are due to anunidentified defect in vitamin D metabolism rather than to excessiveintake.

[Guest guest]

But do the studies say that people in higher lats need more vit D? Maybe someone in Maine needs 1000 IU but up to now we've been reading stuff that didn't distinguish. But the main problem I have is believing all that vit D got absorbed and converted into useful vit D. Are they saying that even unconverted Vit D is useful for cancer for some reason?

I realize there's a latitude thing with PCa.

Regards.

----- Original Message -----

From: Rodney

Sent: Sunday, August 08, 2004 2:43 PM

Subject: [ ] Re: More on Vitamin D Deficiencies

Hi JW:Another consideration to ........ er ...... consider is the angle of the sun in winter at more northerly latitudes. And whether, when the sun's rays are filtered through much more atmosphere, the wavelengths responsible for provoking the vitamin D response are reduced. There is reason to suspect this possibility.I posted earlier in the year that, as usual, my tarragon plants which are kept in full sun at 70°F all winter, never show any signs of growth until the sun's angle has risen appreciably, by about April. I don't know what else to attribute this effect to other than the sun's angle above the horizon. For certain it is not an effect of temperature. It is possible there could be a similar winter effect on vitamin D production in human skin. Winter is not known for being excessively overcast here. Yet symptoms of vitamin D deficiency do seem to be reported more widely in winter - seasonal affective disorder for example. Of course this is speculation.So it may be that at more northerly latitudes vitamin D supplements in winter are desirable even for those who get appreciable winter sun exposure.Rodney. > So can I draw a conclusion that if I get 20 mins sun per day, I never need a supp of a vit D that does not need to be absorbed? > Must be a northern thing.

[Guest guest]

I believe there is a difference in time of day for balance of beneficial vs.

harmful UV rays (my recollection is mid day was better).

Regarding your plants, as I think I suggested last time you mentioned them,

they may be responding to the increased hours of daylight in summer vs.

winter.

JR

-----Original Message-----

From: Rodney [mailto:perspect1111@...]

Sent: Sunday, August 08, 2004 2:44 PM

Subject: [ ] Re: More on Vitamin D Deficiencies

Hi JW:

Another consideration to ........ er ...... consider is the angle

of the sun in winter at more northerly latitudes. And whether, when

the sun's rays are filtered through much more atmosphere, the

wavelengths responsible for provoking the vitamin D response are

reduced. There is reason to suspect this possibility.

I posted earlier in the year that, as usual, my tarragon plants which

are kept in full sun at 70°F all winter, never show any signs of

growth until the sun's angle has risen appreciably, by about April.

I don't know what else to attribute this effect to other than the

sun's angle above the horizon. For certain it is not an effect of

temperature. It is possible there could be a similar winter effect

on vitamin D production in human skin. Winter is not known for being

excessively overcast here. Yet symptoms of vitamin D deficiency do

seem to be reported more widely in winter - seasonal affective

disorder for example. Of course this is speculation.

So it may be that at more northerly latitudes vitamin D supplements

in winter are desirable even for those who get appreciable winter sun

exposure.

Rodney.

-

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[Guest guest]

That's a textbook.

----- Original Message -----

From: loganruns73

Sent: Sunday, August 08, 2004 10:17 PM

Subject: [ ] Re: More on Vitamin D Deficiencies

Vitamin D2 or D3? The usual natural-food vs synthetic-drug debate applies here. But where's the research?Logan> FYI.> Ford: Clinical Toxicology, 1st ed., Copyright © 2001 W. B. Saunders Company > Pathophysiology> Hypervitaminosis D can result from excessive vitamin D dietary supplementation,[24] inaccurately and excessively fortified dairy products,[28] prolonged use of vitamin D-fortified infant formulas,[39] or ingestion of vitamin D rodenticides. Iatrogenic hypervitaminosis D is seen in poorly monitored vitamin D therapy for disorders such as rickets and hypoparathyroidism.[26] [51] The toxic manifestations are due to hypercalcemia.