Guest guest Posted July 21, 2004 Report Share Posted July 21, 2004 And yet, flax seed may be protective against prostate carcinoma: Urology. 2004 May;63(5):900-4. Related Articles, Links Pilot study to explore effects of low-fat, flaxseed-supplemented diet on proliferation of benign prostatic epithelium and prostate-specific antigen. Demark-Wahnefried W, on CN, Walther PJ, Polascik TJ, son DF, Vollmer RT. Division of Urologic Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA. OBJECTIVES: Dietary factors may influence the prostate and have an impact on prostatic growth and disease. A small number of studies have suggested that flaxseed-supplemented, fat-restricted diets may thwart prostate cancer growth in both animals and humans. Unknown, however, is the potential effect of such a diet on benign prostatic epithelium. METHODS: We undertook a pilot study to explore whether a flaxseed-supplemented, fat-restricted diet affects the proliferation rates in benign epithelium. We also explored the effects on circulating levels of prostate-specific antigen (PSA), total testosterone, and cholesterol. Fifteen men who were scheduled to undergo repeat prostate biopsy were instructed to follow a low-fat (less than 20% kcal), flaxseed-supplemented (30 g/day) diet and were provided with a supply of flaxseed to last throughout the 6-month intervention period. The PSA, total testosterone, and cholesterol levels were determined at baseline and at 6 months of follow-up. Reports from the original and repeat biopsies were compared, and proliferation (MIB-1) rates were quantified in the benign prostatic epithelium. RESULTS: Statistically significant decreases in PSA (8.47 +/- 3.82 to 5.72 +/- 3.16 ng/mL; P = 0.0002) and cholesterol (241.1 +/- 30.8 to 213.3 +/- 51.2 mg/dL; P = 0.012) were observed. No statistically significant change was seen in total testosterone (434.5 +/- 143.6 to 428.3 +/- 92.5 ng/dL). Although 6-month repeat biopsies were not performed in 2 cases because of PSA normalization, of the 13 men who underwent repeat biopsy, the proliferation rates in the benign epithelium decreased significantly from 0.022 +/- 0.027 at baseline to 0.007 +/- 0.014 at 6 months of follow-up (P = 0.0168). CONCLUSIONS: These pilot data suggest that a flaxseed-supplemented, fat-restricted diet may affect the biology of the prostate and associated biomarkers. A randomized controlled trial is needed to determine whether flaxseed supplementation, a low-fat diet, or a combination of the two regimens may be of use in controlling overall prostatic growth. PMID: 15134976 [PubMed - in process] >From: " Rodney " <perspect1111@...> >Reply- > >Subject: [ ] Re: Soy and BPH >Date: Wed, 21 Jul 2004 16:03:48 -0000 > >Hi folks: > >Regarding prostate issues: " Prostate cancer is the most common >cancer found in American males. Physicians diagnosed 198,100 prostate >cancer cases in 2001, according to the National Cancer Institute, and >about 31,500 men died from this disease. In other words, if the >statistics remain constant, 19 out of every 100 men born today will >get prostate cancer ...... " . > >And this, from the same source, may be helpful regarding prevention: > >http://www.tellonefriend.com/pcpp.htm > >Note especially the: " avoid canola and flaxseed oils at all costs. " >No doubt this is because of the ALA content. They should have added >soybean oil to the list of 'avoids' too, I believe. > >Rodney. > >Great to hear your surgery went well, Dennis. > > > > > > > >> Right, using 0.44 per kg. I am actually using a little more >than > > >> that. I figure to try that for a month or so, if no bad side > > >> effects. I got this 2 # can to use up. I notice the stuff >packs > > >> a lot too, so a scoop can be misleading. I just want to see >if it > > >> does effect BPH. > > >> > > >> Regards. > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 22, 2004 Report Share Posted July 22, 2004 Agreed. The number of studies regarding flax seed are few. But the ones I've found relate postive effects. Here's a murine one: Urology. 2002 Nov;60(5):919-24. Related Articles, Links Effect of flaxseed supplementation on prostatic carcinoma in transgenic mice. Lin X, Gingrich JR, Bao W, Li J, Haroon ZA, Demark-Wahnefried W. Division of Urologic Surgery, Department of Surgery, and Center for Aging and Human Development, Duke University Medical Center, Durham, North Carolina 27710, USA. OBJECTIVES: To investigate the effects of flaxseed supplementation on prostatic neoplasia in the transgenic adenocarcinoma mouse prostate (TRAMP) model. METHODS: A total of 135 male TRAMP mice 5 to 6 weeks old were randomized to a control group (AIN-76A diet) or an experimental group (AIN-76A diet plus 5% flaxseed by weight). One half of the mice in each group were treated for 20 weeks and the remainder for 30 weeks. At autopsy, urogenital tissues (four prostatic lobes, seminal vesicles, and emptied bladder), lungs, lymph nodes, and grossly abnormal tissues were collected for histologic evaluation. RESULTS: Of the control mice, 100% developed prostate cancer versus 97% of the mice in the flaxseed group. The tumor/urogenital weight was 3.6 +/- 0.4 g in the controls versus 1.9 +/- 0.2 g in the flaxseed-treated mice (P = 0.0005). At 20 weeks, no significant difference in tumor grade was seen between the two groups; however, at 30 weeks, the flaxseed-treated mice had significantly less aggressive tumors than did the controls (P = 0.01). The prevalence of lung and lymph node metastases was 13% and 16%, respectively, in the control mice versus 5% and 12%, respectively, in the experimental group (difference not significant). After 20 weeks of treatment, cellular proliferation (Ki-67) differed significantly between the control and experimental groups (38.1 +/- 2.03 versus 26.2 +/- 2.03; P <0.0001), and the apoptotic index (deoxynucleotidyl transferase-mediated dUTP-digoxigenin nick end labeling) was 1.45 +/- 0.14 versus 3.3 +/- 0.31 (P <0.0001). Similar differences were seen after 30 weeks of treatment. CONCLUSIONS: A diet supplemented with 5% flaxseed inhibits the growth and development of prostate cancer in the TRAMP model. PMID: 12429338 [PubMed - indexed for MEDLINE] I'm still grinding up a bit of flax seed for my smoothies. I don't particularly advocate the intake of oils in general, with the possible exception of EPA and DHA. >From: " Rodney " <perspect1111@...> >Reply- > >Subject: [ ] Re: Soy and BPH >Date: Wed, 21 Jul 2004 22:12:27 -0000 > >Hi : > >Well that is fifteen men, compared with a fourteen year prospective >study of 48,000 in the study posted. > >But we iz all over 21 here. > >Rodney. > > > > > > > > > > > >> Right, using 0.44 per kg. I am actually using a little >more > > >than > > > > >> that. I figure to try that for a month or so, if no bad >side > > > > >> effects. I got this 2 # can to use up. I notice the >stuff > > >packs > > > > >> a lot too, so a scoop can be misleading. I just want to >see > > >if it > > > > >> does effect BPH. > > > > >> > > > > >> Regards. > > > > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 22, 2004 Report Share Posted July 22, 2004 General health benefits, hopefully, including decreased risk of cancer, heart disease, inflammatory related disorders, auto-immune disorders, for the fiber, etc.... Fer instance: Cancer Lett. 2002 Nov 8;185(1):31-7. Related Articles, Links Flaxseed inhibits metastasis and decreases extracellular vascular endothelial growth factor in human breast cancer xenografts. Dabrosin C, Chen J, Wang L, LU. Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, 150 College Street, ON, M5S 3E2, Toronto, Canada. Angiogenesis is important in tumor growth, progression and metastatic dissemination. Vascular endothelial growth factor (VEGF) is one key factor in promotion of breast cancer angiogenesis. VEGFs are bioactive in the extracellular space where they become available to the endothelial cells. Phytoestrogens such as lignans have been shown to alter breast cancer incidence and be cancer-protective in rats. We show that supplementation of 10% flaxseed, the richest source of mammalian lignans, to nude mice with established human breast tumors reduced tumor growth and metastasis. Moreover, flaxseed decreased extracellular levels of VEGF, which may be one mechanistic explanation to the decreased tumor growth and metastasis. PMID: 12142076 [PubMed - indexed for MEDLINE] >From: " Rodney " <perspect1111@...> >Reply- > >Subject: [ ] Re: Soy and BPH >Date: Thu, 22 Jul 2004 12:24:55 -0000 > >Hi : > >If I may ask, what is the benefit you are hoping to get from the >flax? If it is a CHD benefit you are looking for, do you not think >that CR will erase any possible risk to yourself from that source? > >Rodney. > > > > > ............ I'm still grinding up a bit of flax seed for > > smoothies ....... > Quote Link to comment Share on other sites More sharing options...
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