Resveratrol/NAD (was: Re: What is Caloric Restriction?)

[Guest guest]

I think you're confusing the SIR2p gene silencing with the SIR2 gene

expression.

NAD (nicotinamide) is a key player in cellular energy metabolism, in

which glucose molecules are broken down to produce the life-giving

energy that every cell requires. That process is called glycosis and

it requires an ample supply of NAD to keep it going. When glucose

levels decline (such as during calore restriction and fasting), the

cell's available NAD reserves increase and demand is reduced, because

it's not being used up during glycosis. Thus, more NAD is available

for gene silencing.

Said another way:

Resveratrol == Expresses SIR2 gene which codes for proteins (SIR2p)

NAD == Vital co-factor for SIR2p to perform gene silencing functions

Thus, saturating the body with NAD when taking resveratrol (or doing

CRON) will assure the SIR2p of doing their job. No NAD, no gene

silencing by SIR2p, no gene-silencing by SIR2p, no lifespan extension

attributed to SIR2.

There is also some evidence NAD resets the Hayflick limit.

Logan

>

> > In the testing of resveratrol, there was no additional maximum

> > lifespan extension when given to CR mice. Thus, you can simply

> take a resveratrol supplement (and niacinimide to help reinforce it)