RE: Re: Lower Total Cholesterol >>> Live Longer

[Guest guest]

Unclear, I guess:

J Am Geriatr Soc. 2003 Jan;51(1):80-4. Related Articles, Links

Does inflammation or undernutrition explain the low cholesterol-mortality

association in high-functioning older persons? MacArthur studies of

successful aging.

Hu P, Seeman TE, TB, Reuben DB.

Multicampus Program in Geriatric Medicine and Gerontology, UCLA School of

Medicine, Los Angeles, California 90095, USA. phu@...

OBJECTIVES: To explore the effect of inflammation and undernutrition on the

association between hypocholesterolemia and higher overall mortality in

high-functioning older persons. DESIGN: Prospective cohort study. SETTING:

Three U.S. communities. PARTICIPANTS: A cohort of 870 participants from the

MacArthur Studies of Successful Aging. MEASUREMENTS: Baseline information

was obtained for serum levels of cholesterol, C-reactive protein,

interleukin-6, and albumin; body mass index; prevalent medical conditions;

health behaviors; and medications. Crude and multivariate logistic

regression analyses were used to examine the association between serum total

cholesterol levels and 7-year all-cause mortality, while adjusting for

potential confounders. RESULTS: In univariate analysis, the risk ratio of

low serum total cholesterol level (<169 mg/dL) for 7-year total mortality

was 1.90 (95% confidence interval (CI) = 1.18-3.07). The multiple adjusted

risk ratios were 1.82 (95% CI = 1.10-3.00) after controlling for markers of

inflammation and nutrition and 1.39 (95% CI = 0.80-2.40) after adjustment

for additional cardiovascular risk factors. Sex was an important confounding

variable that contributed to the observed inverse association between low

serum cholesterol and overall mortality in univariate analysis. CONCLUSIONS:

Hypocholesterolemia is not an independent risk factor for increased overall

mortality in high-functioning community-dwelling older men and women. The

association between low total cholesterol and high mortality observed in

crude analysis is mainly confounded by common cardiovascular risk factors,

rather than underlying inflammation or undernutrition.

MeSH Terms:

Aged

Body Mass Index

Cause of Death

Cholesterol/blood*

Epidemiologic Studies

Female

Geriatric Assessment

Health Status*

Human

Inflammation/mortality*

Logistic Models

Male

Nutrition Disorders/blood

Nutrition Disorders/mortality*

Prospective Studies

Risk Factors

Serum Albumin/deficiency*

Support, Non-U.S. Gov't

Substances:

Serum Albumin

Cholesterol

PMID: 12534850 [PubMed - indexed for MEDLINE]

>From: " Rodney " <perspect1111@...>

>Reply-

>

>Subject: [ ] Re: Lower Total Cholesterol >>> Live Longer

>Date: Mon, 13 Sep 2004 23:37:17 -0000

>

>Hi :

>

>I am not aware of any lower limit for non-smokers. But I do remember

>a major european study (was it in Hamburg?) found that very low LDL

>among smokers was associated with increased total mortality because

>of increased cancer incidence. Not exactly sure why. I believe the

>data were posted here, perhaps six months ago.

>

>The effects were large enough for smokers that the data for the total

>population also showed higher total mortality at very low LDL

>levels ....... being dragged up solely by the data from the smoking

>contingent.

>

>Rodney.

>

>

> > How low, if any value, is too low for total cholesterol?

> >

> >

> > >From: " Jeff Novick " <jnovick@p...>

> > >Reply-

> > >< >

> > >Subject: RE: [ ] Lower Total Cholesterol >>> Live

>Longer

> > >Date: Mon, 13 Sep 2004 16:24:05 -0400

> > >

> > >

> > >From the Study Rodney posted today..

> > >

> > > >>Researchers found that a total cholesterol level of 193 or

>lower at

> > >age 30 to 45 was associated with a 25% lower risk of death nearly

>four

> > >decades later.

> > >

> > >Well, Data from Framingham Heart Study showed that men in their

>30s with

> > >TC in the bottom 25% had about half the risk of dying from all

>causes

> > >just 3 years latter.

>

[Guest guest]

Thanks, Rodney-

That's reassuring: my latest total cholesterol was 111 mg/dl!

>From: " Rodney " <perspect1111@...>

>Reply-

>

>Subject: [ ] Re: Lower Total Cholesterol >>> Live Longer

>Date: Tue, 14 Sep 2004 12:10:14 -0000

>

>Hi :

>

>For what looks like some fairly authoritative data on this issue take

>a look at post #13233, from the 'PROCAM' study - also called the

>Münster Heart Study:

>

>http://www.chd-taskforce.de/slidekit/kit4/slide2.htm

>

>http://snipurl.com/7f2n

>

>You will see an increase in mortality with lower LDL only for smokers.

>

>Rodney.

>

>

> > How low, if any value, is too low for total cholesterol?

> >

> >

> > >From: " Jeff Novick " <jnovick@p...>

> > >Reply-

> > >< >

> > >Subject: RE: [ ] Lower Total Cholesterol >>> Live

>Longer

> > >Date: Mon, 13 Sep 2004 16:24:05 -0400

> > >

> > >

> > >From the Study Rodney posted today..

> > >

> > > >>Researchers found that a total cholesterol level of 193 or

>lower at

> > >age 30 to 45 was associated with a 25% lower risk of death nearly

>four

> > >decades later.

> > >

> > >Well, Data from Framingham Heart Study showed that men in their

>30s with

> > >TC in the bottom 25% had about half the risk of dying from all

>causes

> > >just 3 years latter.

>

[Guest guest]

Cholesterol 111 mg/dl

(140-200 mg/dl)

LDL 34 mg/dl

HDL 67 mg/dl > or = 40

mg/dl

Chol/HDL Ratio 1.7

>From: " Rodney " <perspect1111@...>

>Reply-

>

>Subject: [ ] Re: Lower Total Cholesterol >>> Live Longer

>Date: Tue, 14 Sep 2004 12:55:03 -0000

>

>Hi :

>

>How much of that is HDL?

>

>Rodney.

>

>

> > > > How low, if any value, is too low for total cholesterol?

> > > >

> > > >

> > > > >From: " Jeff Novick " <jnovick@p...>

> > > > >Reply-

> > > > >< >

> > > > >Subject: RE: [ ] Lower Total Cholesterol >>> Live

> > >Longer

> > > > >Date: Mon, 13 Sep 2004 16:24:05 -0400

> > > > >

> > > > >

> > > > >From the Study Rodney posted today..

> > > > >

> > > > > >>Researchers found that a total cholesterol level of 193 or

> > >lower at

> > > > >age 30 to 45 was associated with a 25% lower risk of death

>nearly

> > >four

> > > > >decades later.

> > > > >

> > > > >Well, Data from Framingham Heart Study showed that men in their

> > >30s with

> > > > >TC in the bottom 25% had about half the risk of dying from all

> > >causes

> > > > >just 3 years latter.

> > >

>

[Guest guest]

Triglycerides 54 mg/dl

(10-150 mg/dl)

I don't know if these results are as good as the ones I got 2 years ago,

when I was on the hard core " low carb " diet:

Cholesterol 151 mg/dl 175-260

LDL 36 mg/dl

HDL 105 mg/dl

Chol/HDL Ratio 1.4

>From: " Rodney " <perspect1111@...>

>Reply-

>

>Subject: [ ] Re: Lower Total Cholesterol >>> Live Longer

>Date: Tue, 14 Sep 2004 13:18:27 -0000

>

>So triglycerides was 50? Pretty amazing set of data!

>

>Rodney.

>

>

> > > > > > How low, if any value, is too low for total cholesterol?

> > > > > >

> > > > > >

> > > > > > >From: " Jeff Novick " <jnovick@p...>

> > > > > > >Reply-

> > > > > > >< >

> > > > > > >Subject: RE: [ ] Lower Total Cholesterol >>>

>Live

> > > > >Longer

> > > > > > >Date: Mon, 13 Sep 2004 16:24:05 -0400

> > > > > > >

> > > > > > >

> > > > > > >From the Study Rodney posted today..

> > > > > > >

> > > > > > > >>Researchers found that a total cholesterol level of 193

>or

> > > > >lower at

> > > > > > >age 30 to 45 was associated with a 25% lower risk of death

> > >nearly

> > > > >four

> > > > > > >decades later.

> > > > > > >

> > > > > > >Well, Data from Framingham Heart Study showed that men in

>their

> > > > >30s with

> > > > > > >TC in the bottom 25% had about half the risk of dying from

>all

> > > > >causes

> > > > > > >just 3 years latter.

> > > > >

> > >

>

[Guest guest]

Yup! Bacon, sausage, eggs, eggs, eggs (albeit high omega 3), cheese, nuts,

along with veggies, soy protein, whey protein, etc.

Only did it for a relatively short period.

>From: " freebird5005 " <freebird5005@...>

>Reply-

>

>Subject: [ ] Re: Lower Total Cholesterol >>> Live Longer

>Date: Tue, 14 Sep 2004 14:06:48 -0000

>

> " hardcore low carb diet " ? the Atkins diet?

>

>

>

> > > > > > > > How low, if any value, is too low for total cholesterol?

> > > > > > > >

> > > > > > > >

> > > > > > > > >From: " Jeff Novick " <jnovick@p...>

> > > > > > > > >Reply-

> > > > > > > > >< >

> > > > > > > > >Subject: RE: [ ] Lower Total Cholesterol >>>

> > >Live

> > > > > > >Longer

> > > > > > > > >Date: Mon, 13 Sep 2004 16:24:05 -0400

> > > > > > > > >

> > > > > > > > >

> > > > > > > > >From the Study Rodney posted today..

> > > > > > > > >

> > > > > > > > > >>Researchers found that a total cholesterol level of 193

> > >or

> > > > > > >lower at

> > > > > > > > >age 30 to 45 was associated with a 25% lower risk of death

> > > > >nearly

> > > > > > >four

> > > > > > > > >decades later.

> > > > > > > > >

> > > > > > > > >Well, Data from Framingham Heart Study showed that men in

> > >their

> > > > > > >30s with

> > > > > > > > >TC in the bottom 25% had about half the risk of dying from

> > >all

> > > > > > >causes

> > > > > > > > >just 3 years latter.

> > > > > > >

> > > > >

> > >

>

[Guest guest]

Yeah, odd results, eh? Perhaps due to my propensity for

hypersupplementation, in addition to CRON.

I've been CRON for many years. I think I recall doing an in-office spot

cholesterol before I really got into CR with total cholesterol of about 175

mg/dl, but, even then, I was probably somewhat CR (been into vegetarianism,

fasting, since sophomore year of college).

My dad is on Lipitor, but I don't know what his numbers are or were before

that. My sibs are younger than me (I'm 41) so I doubt they even know their

numbers.

>From: " old542000 " <apater@...>

>Reply-

>

>Subject: [ ] Re: Lower Total Cholesterol >>> Live Longer

>Date: Tue, 14 Sep 2004 18:55:58 -0000

>

>

> > > >

> > > > Cholesterol 111

> > >mg/dl

> > > > (140-200 mg/dl)

> > > >

> > > > LDL 34 mg/dl

> > > > HDL 67

> > >mg/dl > or = 40

> > > > mg/dl

> > > > Chol/HDL Ratio 1.7

>

>

>Hi All,

>

>Yes, the numbers amaze.

>

>For example, the total cholesterol/HDL ratio exceeds

>even the standard deviation of values of CRers

>in the WUSTL study.

>

>What were levels of lipids before your CRON and what

>are they for your other family members, Chris?

>

>Cheers, Al Pater.

>

[Guest guest]

Kinda looks like that, to me.

>From: " freebird5005 " <freebird5005@...>

>Reply-

>

>Subject: [ ] Re: Lower Total Cholesterol >>> Live Longer

>Date: Tue, 14 Sep 2004 20:19:55 -0000

>

>Are you suggesting that your lipid profile was even better on a diet

>of bacon and sausage??

>

>

> > > > > > > > > > How low, if any value, is too low for total cholesterol?

> > > > > > > > > >

> > > > > > > > > >

> > > > > > > > > > >From: " Jeff Novick " <jnovick@p...>

> > > > > > > > > > >Reply-

> > > > > > > > > > >< >

> > > > > > > > > > >Subject: RE: [ ] Lower Total

>Cholesterol >>>

> > > > >Live

> > > > > > > > >Longer

> > > > > > > > > > >Date: Mon, 13 Sep 2004 16:24:05 -0400

> > > > > > > > > > >

> > > > > > > > > > >

> > > > > > > > > > >From the Study Rodney posted today..

> > > > > > > > > > >

> > > > > > > > > > > >>Researchers found that a total cholesterol level

>of 193

> > > > >or

> > > > > > > > >lower at

> > > > > > > > > > >age 30 to 45 was associated with a 25% lower risk

>of death

> > > > > > >nearly

> > > > > > > > >four

> > > > > > > > > > >decades later.

> > > > > > > > > > >

> > > > > > > > > > >Well, Data from Framingham Heart Study showed that

>men in

> > > > >their

> > > > > > > > >30s with

> > > > > > > > > > >TC in the bottom 25% had about half the risk of

>dying from

> > > > >all

> > > > > > > > >causes

> > > > > > > > > > >just 3 years latter.

> > > > > > > > >

> > > > > > >

> > > > >

> > >

>

[Guest guest]

I'm just reporting the lab results. I'm not making a claim the high animal

fat low carb diet is healthier. I have since given it up because I had

concerns regarding its long term health effects.

>From: " freebird5005 " <freebird5005@...>

>Reply-

>

>Subject: [ ] Re: Lower Total Cholesterol >>> Live Longer

>Date: Wed, 15 Sep 2004 20:56:21 -0000

>

>Sat fats from animal sources is primary source of serum cholesterol

>but dietary cholesterol will also increase serum cholesterol.

>

>I find it hard to believe his numbers were even better eating all that

>fat.

>

>

> > > > > > Triglycerides 54 mg/dl

> > > > >

> > > > > > (10-150 mg/dl)

> > > > > >

> > > > > > I don't know if these results are as good as the ones I got 2

> > years

> > > > >ago,

> > > > > > when I was on the hard core " low carb " diet:

> > > > > >

> > > > > >

> > > > > > Cholesterol 151 mg/dl 175-260

> > > > > > LDL 36 mg/dl

> > > > > > HDL 105 mg/dl

> > > > > > Chol/HDL Ratio 1.4

>

[Guest guest]

Yeah, it IS hard to believe. All I know is it wouldn't work for me. I'd probably have tubes in my arms at this moment if I tried that.

freebird5005 <freebird5005@...> wrote:

Sat fats from animal sources is primary source of serum cholesterolbut dietary cholesterol will also increase serum cholesterol.I find it hard to believe his numbers were even better eating all thatfat.> > > > > Triglycerides 54 mg/dl> > > >> > > > > (10-150 mg/dl)> > > > >> > > > > I don't know if these results are as good as the ones I got 2> years> > > >ago,> > > > > when I was on the hard core "low carb" diet:> > > > >> > > > >> > > > > Cholesterol 151 mg/dl 175-260> > > > > LDL 36 mg/dl> > > > > HDL 105 mg/dl> > > > > Chol/HDL Ratio 1.4__________________________________________________