Re: Supplement to Stop Muscle Wastage

[Guest guest]

This study corroborates well with sports nutrition research where the

consensus is for taking .8g/kg CHO and .4g/kg PRO to halt catabolism

and increase anabolism during recovery [PMID: 15105028, PMID:

15105028, PMID: 12235033].

A very powerful amino acid complex for promoting anabolism is called

Ornithine Ketoglutarate (OKG) [PMID: 10890617, PMID: 10601539]. To

my knowledge, it hasn't been made widely available commercially. It

has been used for burn victims in Europe for over 20 years.

A lesson from all this for CRONers who want to avoid Sarcopenia may

be: don't eat normal [slow-digesting] proteins or fat at the same

time as with high insulinic carbohydrates like sweet potatoes, corn,

carrots, etc., if you don't want to blunt the insulin response

necessary for halting catabolism. (There was some half-truth in the

old adage of " breaking your fast " with fruit!)

Logan

Essential Amino Acid and Carbohydrate Supplementation Ameliorates

Muscle Protein Loss in Humans during 28 Days Bedrest.

Paddon- D, Sheffield- M, Urban RJ, Sanford AP, Aarsland A,

Wolfe RR, Ferrando AA.

Metabolism Unit, 815 Market Street, Galveston, Texas 77550.

djpaddon@...

J Clin Endocrinol Metab. 2004 Sep;89(9):4351-8.

We determined whether essential amino acid and carbohydrate

supplementation could offset the catabolic response to prolonged

inactivity. Major outcome measures included mixed muscle fractional

synthetic rate (FSR), phenylalanine net balance, lean leg mass, and

leg extension strength. On d 1 and 28, vastus lateralis muscle

biopsies and femoral arterio-venous blood samples were obtained

during a primed constant infusion of l-[ring-(2)H(5)]phenylalanine.

Net balance and FSR were calculated over 16 h, during which the

control group (CON) received a nutritionally mixed meal every 5 h

(0830, 1330, and 1830 h). The experimental group (EXP) also consumed

16.5 g essential amino acids and 30 g carbohydrate (1100, 1600, and

2100 h). The dietary regimen was maintained during bedrest. FSR was

higher in the EXP group on d 1 (EXP, 0.099 +/- 0.008%/h; CON: 0.075

+/- 0.005%/h) and d 28 (EXP, 0.093 +/- 0.006%/h; CON, 0.055 +/-

0.007%/h). Lean leg mass was maintained throughout bedrest in the EXP

group (+0.2 +/- 0.3 kg), but fell in the CON group (-0.4 +/- 0.1 kg).

Strength loss was more pronounced in the CON group (EXP, -8.8 +/- 1.4

kg; CON, -17.8 +/- 4.4 kg). Essential amino acid and carbohydrate

supplementation may represent a viable intervention for individuals

at risk of sarcopenia due to immobility or prolonged bedrest.