Apo A1/Apo B

[Guest guest]

Hi folks:

This raises an interesting question about the people here who have

LDL below 50 and HDL above 100. The question is: " How much of their

HDL is the highly beneficial Apo A1, and how much the other component

(s) of HDL? " .

In other words, does their Apo A1/Apo B ratio look as good as their

HDL/LDL ratio? Of course the answer may well be that it doesn't make

any material difference when their LDL is that low and HDL that high.

Rodney.

> > Reduction of dietary saturated fatty acids correlates with

> increased

> > plasma lecithin cholesterol acyltransferase activity in humans.

> >

> > Berard AM, Dabadie H, Palos-Pinto A, Dumon MF, Darmon M.

> >

> > Laboratoire de Biochimie et de Biologie Moleculaire, Universite

> > Victor Segalen Bordeaux, Bordeaux, France. annie.berard@u...

> >

> > Eur J Clin Nutr. 2004 Jun;58(6):881-7.

> >

> > OBJECTIVE: Increased HDL-cholesterol (HDL-C) concentrations have

> been

> > associated with lower coronary heart disease risk. On the other

> hand,

> > dietary fats are known to influence the fatty acid profile of

> plasma

> > lipids, including phospholipids that are substrates of lecithin

> > cholesterol acyltransferase (LCAT), an important enzyme in HDL

> > metabolism. The purpose of this study was to examine the

> association

> > between the saturated fatty acid (SFA) intake and LCAT activity.

> > DESIGN: An interventional study was performed in a monk community

> of

> > 25 men. SETTING: A French monk community, South West of France.

> > SUBJECTS AND INTERVENTIONS: The basal diet of the study cohort

> > contained SFA in a proportion of 13.5% of their total energy

intake

> > (TEI). They were submitted to two experimental isocaloric diets

> > containing either 8.4% of the TEI in SFA (diet A) or 11% (diet

,

> > each lasting 5 weeks. RESULTS: The elevation of SFA in diet B was

> > mainly obtained by decreasing carbohydrates. The only significant

> > difference among total fats between diets A and B was the

myristic

> > acid content (0.6 and 1.2% of TEI, respectively). The elevation

in

> > SFA in diet B resulted in a significant increase of HDL-C

(P<0.04),

> > while plasma apo A-I concentration and LCAT activity both

decreased

> > (P<0.02). CONCLUSION: Altogether, these results are consistent

with

> a

> > negative effect of SFA on reverse cholesterol transport.