Apo B/Apo A1 .......... was Apo A1/Apo B

[Guest guest]

Hi folks:

Oooops. Correction. I see, I think, that I got the ratio upside

down!

It should be Apo B/Apo A1, where the lower the ratio the better.

High Apo B is bad. High Apo A1 is good.

Rodney.

> > > Reduction of dietary saturated fatty acids correlates with

> > increased

> > > plasma lecithin cholesterol acyltransferase activity in humans.

> > >

> > > Berard AM, Dabadie H, Palos-Pinto A, Dumon MF, Darmon M.

> > >

> > > Laboratoire de Biochimie et de Biologie Moleculaire, Universite

> > > Victor Segalen Bordeaux, Bordeaux, France. annie.berard@u...

> > >

> > > Eur J Clin Nutr. 2004 Jun;58(6):881-7.

> > >

> > > OBJECTIVE: Increased HDL-cholesterol (HDL-C) concentrations have

> > been

> > > associated with lower coronary heart disease risk. On the other

> > hand,

> > > dietary fats are known to influence the fatty acid profile of

> > plasma

> > > lipids, including phospholipids that are substrates of lecithin

> > > cholesterol acyltransferase (LCAT), an important enzyme in HDL

> > > metabolism. The purpose of this study was to examine the

> > association

> > > between the saturated fatty acid (SFA) intake and LCAT

activity.

> > > DESIGN: An interventional study was performed in a monk

community

> > of

> > > 25 men. SETTING: A French monk community, South West of France.

> > > SUBJECTS AND INTERVENTIONS: The basal diet of the study cohort

> > > contained SFA in a proportion of 13.5% of their total energy

> intake

> > > (TEI). They were submitted to two experimental isocaloric diets

> > > containing either 8.4% of the TEI in SFA (diet A) or 11% (diet

> ,

> > > each lasting 5 weeks. RESULTS: The elevation of SFA in diet B

was

> > > mainly obtained by decreasing carbohydrates. The only

significant

> > > difference among total fats between diets A and B was the

> myristic

> > > acid content (0.6 and 1.2% of TEI, respectively). The elevation

> in

> > > SFA in diet B resulted in a significant increase of HDL-C

> (P<0.04),

> > > while plasma apo A-I concentration and LCAT activity both

> decreased

> > > (P<0.02). CONCLUSION: Altogether, these results are consistent

> with

> > a

> > > negative effect of SFA on reverse cholesterol transport.