Myristic Lower in MI Cases

September 7, 2004

Hi folks:

Just to confuse the issue, here is one suggesting lower myristic acid

in myocardial infarction cases, compared with controls. (But I have

also found one other source suggesting myristic is more atherogenic)

And oleic and linoleic were higher in cases! ...............

" Serum free fatty acid pattern and risk of myocardial infarction: a

case-control study.

Yli-Jama P, Meyer HE, Ringstad J, Pedersen JI.

Institute for Nutrition Research, Medical Faculty, University of

Oslo, Norway.

OBJECTIVES: To investigate the association between composition of

serum free fatty acid (FFA) fraction and risk of a first myocardial

infarction (MI). DESIGN: A case-control design. SETTING: The patients

were recruited from Ulleval Hospital in Oslo and Ostfold Central

Hospital in Fredrikstad and Sarpsborg, Norway. SUBJECTS: A total of

103 patients with first MI and 104 population controls, both men and

postmenopausal women, age 45-75 years. RESULTS: The mean molar

percentage content of docosahexaenoic (DHA), eicosapentaenoic (EPA),

stearic and myristic acid in the serum FFA fraction was significantly

lower in cases than in controls, whereas that of oleic and linoleic

acid was higher in cases. Increased percentage content of total very

long-chain omega-3 fatty acids (VLC n-3) in serum FFA was associated

with decreased risk of MI. Multivariate odds ratio (OR), adjusted for

age, sex, waist-hip ratio, smoking, family history of coronary heart

disease (CHD) and years of education was 0.20 (95% CI 0.06-0.63) for

the highest vs. lowest quartile. Also increased content of stearic

acid was associated with decreased risk. Multivariate OR adjusted as

above was 0.38 (95% CI 0.14-1.04) for the highest versus lowest

quartile. After adjustment for oleic acid, however, the inverse

linear trend was no longer significant. CONCLUSIONS: The percentage

content of VLC n-3 as well as of stearic acid in serum FFA was

inversely associated with risk of myocardial infarction. That of VLC

n-3 may reflect diet, but additionally these free fatty acids might

in some way be related to the pathogenetic process and not only

reflect their content in adipose tissue.

PMID: 11851861 [PubMed - indexed for MEDLINE] "

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