Re: Re: Prostate Cancer Information

[Guest guest]

The facts in the writeup below may be true, however not much in the way of

citations, and parts read like a commercial for Barry Sears (who as I

recall was not very highly regarded by Walford).

on 8/24/2004 8:50 PM, old542000 at apater@... wrote:

>

>

> Hi All,

>

> See the below for prostate cancer prevention.

>

> http://lifeextensionvitamins.com/prcapa2.html

>

> .....

>

> Reduction of Total Calorie Consumption Decreases Tumor Size by

> Decreasing VEGF, Angiogenesis, and IGF-1 and by Increasing Apoptosis

>

> The emphasis on dietary fat, per se, has lessened our focus on the

> importance of caloric over-consumption. Fat excess, however, is

> linked to excessive calorie consumption, since fat contains twice as

> many calories, gram for gram, as protein or carbohydrate.

>

> I believe that diet should be regarded as having serious biochemical

> relevance to the health of the individual. You are, for the most

> part, what you eat (or at least what you assimilate). Western

> societies, especially the United States, are consumers of excessive

> calories. Excessive caloric consumption, especially coupled with a

> sedentary lifestyle, is a significant factor that adversely affects

> longevity.

>

> An important study demonstrated that energy intake (caloric intake)

> modulates the growth of prostate tumors in two animal models: the

> androgen-dependent Dunning R3327-H adenocarcinoma in rats and the

> androgen-sensitive LNCaP human adenocarcinoma in severe combined

> immunodeficiency (SCID) mice.31 Specifically, decreasing calorie

> consumption (energy restriction) by 20-40% from the control animals

> fed ad libitum resulted in:

> Increased PC cell apoptosis (programmed cell death)

> A two- to threefold reduction in PC angiogenesis as measured by

> microvessel density

> A decrease in vascular endothelial growth factor (VEGF) _expression

> A decrease in circulating levels of IGF-1

> A significant decrease in tumor size

> Therefore, all of these findings were benefits observed in the

> calorie-restricted group. This study showed that the nutritional

> status directly or indirectly influenced interaction between tumor

> cells and local blood vessels by changing the _expression of

> angiogenic growth factors. In the Dunning model, energy (calorie)

> restriction resulted in a striking inhibition of VEGF _expression. In

> the LNCaP model, there was little baseline _expression of VEGF.

> However, there was an almost threefold reduction from the baseline

> IGF-1 levels in blood samples from LNCaP-bearing mice that were

> subjected to energy restriction.

>

> ...

>

> Good News! GLA and EPA Inhibit uPA. Of interest is the fact that uPA

> production is inhibited by gamma-linolenic acid (GLA) and

> eicosapentenoic acid (EPA).37 GLA and EPA, which are essential fatty

> acids, are among the important players in the prevention of disease

> and in maintenance of health. This is discussed by Barry Sears,

> Ph.D., in Omega Rx Zone.38 Sears beautifully presents the

> interconnection between restriction of calories, along with dietary

> adjustments of carbohydrate, protein, and fat intake, and the

> production of a class of fatty acids called eicosanoids. An

> understanding of these issues is fundamental to our ability to

> prevent disease and maintain or recapture health.

>

> More Advantages to Caloric Restriction and Avoidance of

> Hyperinsulinemia. Sears stresses the importance of caloric

> restriction by means of limiting the intake of high-density

> carbohydrates such as bread, pasta, grains in most cereals, and

> starches such as those found in potatoes. This reduction of caloric

> intake by lowering high-density carbohydrate intake decreases the

> stimulation of the pancreas to make insulin and limits all the

> adverse side effects associated with increased insulin levels

> (hyperinsulinemia).

>

> Caloric restriction has been shown to be an important factor in

> augmenting the immune system and improving longevity. Caloric

> restriction reduces free radical production, which if otherwise

> unchecked, damages DNA and oxidizes polyunsaturated fats. Caloric

> restriction increases levels of superoxide dismutase (SOD),

> glutathione, melatonin, DHEA, peroxidase, and catalase. The latter

> substances are important defense mechanisms in our body that are

> known to decrease with aging. Caloric restriction is instrumental in

> lowering the production of cortisol. Cortisol is associated with

> increased stress levels, and an imbalance in cortisol production

> leads to immune deficiency and bone loss through resorption, leading

> to osteopenia and osteoporosis, as well as muscle breakdown and aging

> of the skin.

>

> Calorie restriction, as proposed by Sears and others, has been shown

> to also reduce advanced glycosylated end-products (AGE). These are

> carbohydrate-protein complexes associated with hyperinsulinemic

> states; they are associated with cardiovascular disease, Alzheimer's

> disease, kidney disease, and other degenerative states.

>

> We need to rethink how much food we need to eat. Our ideal body

> weight should be taken seriously. If we were to do this alone, we

> would eliminate most cases of diabetes, hypertension,

> hypercholesterolemia, stroke, heart disease, and a significant amount

> of cancer from our lives and those of our loved ones. We should

> consume 500 calories a meal and 100 calories a snack. Modifications

> of this are based on the level of activity, age, and body surface

> area. Nutritional software and nutritional counseling should be an

> integral part of our approach to good health.

>

> ...