Re: Prostate Cancer Information

[Guest guest]

anyone know who the I is?

"I believe that diet should be regarded as having serious biochemical relevance to the health of the individual."

Regards.

----- Original Message -----

From: Rodney

Sent: Tuesday, August 24, 2004 6:45 AM

Subject: [ ] Prostate Cancer Information

Hi folks:For those interested in prostate cancer there seems to be a huge amount of good information here:http://lifeextensionvitamins.com/prcapa2.html(Please note that the site does have a commercial interest in the matter)Rodney.

[Guest guest]

Hi JW:

My guess is that it is the owner of this store, in Fort Lauderdale:

http://www.lef.org/about_us/images/le_building.jpg

Just a guess.

Rodney.

--- In , " jwwright " <jwwright@e...>

wrote:

> anyone know who the I is?

> " I believe that diet should be regarded as having serious

biochemical relevance to the health of the individual. "

>

> Regards.

>

> ----- Original Message -----

> From: Rodney

>

> Sent: Tuesday, August 24, 2004 6:45 AM

> Subject: [ ] Prostate Cancer Information

>

>

> Hi folks:

>

> For those interested in prostate cancer there seems to be a huge

> amount of good information here:

>

> http://lifeextensionvitamins.com/prcapa2.html

>

> (Please note that the site does have a commercial interest in the

> matter)

>

> Rodney.

[Guest guest]

--- In , " Rodney " <perspect1111@y...>

wrote:

Hi All,

See the below for prostate cancer prevention.

http://lifeextensionvitamins.com/prcapa2.html

......

Reduction of Total Calorie Consumption Decreases Tumor Size by

Decreasing VEGF, Angiogenesis, and IGF-1 and by Increasing Apoptosis

The emphasis on dietary fat, per se, has lessened our focus on the

importance of caloric over-consumption. Fat excess, however, is

linked to excessive calorie consumption, since fat contains twice as

many calories, gram for gram, as protein or carbohydrate.

I believe that diet should be regarded as having serious biochemical

relevance to the health of the individual. You are, for the most

part, what you eat (or at least what you assimilate). Western

societies, especially the United States, are consumers of excessive

calories. Excessive caloric consumption, especially coupled with a

sedentary lifestyle, is a significant factor that adversely affects

longevity.

An important study demonstrated that energy intake (caloric intake)

modulates the growth of prostate tumors in two animal models: the

androgen-dependent Dunning R3327-H adenocarcinoma in rats and the

androgen-sensitive LNCaP human adenocarcinoma in severe combined

immunodeficiency (SCID) mice.31 Specifically, decreasing calorie

consumption (energy restriction) by 20-40% from the control animals

fed ad libitum resulted in:

Increased PC cell apoptosis (programmed cell death)

A two- to threefold reduction in PC angiogenesis as measured by

microvessel density

A decrease in vascular endothelial growth factor (VEGF) _expression

A decrease in circulating levels of IGF-1

A significant decrease in tumor size

Therefore, all of these findings were benefits observed in the

calorie-restricted group. This study showed that the nutritional

status directly or indirectly influenced interaction between tumor

cells and local blood vessels by changing the _expression of

angiogenic growth factors. In the Dunning model, energy (calorie)

restriction resulted in a striking inhibition of VEGF _expression. In

the LNCaP model, there was little baseline _expression of VEGF.

However, there was an almost threefold reduction from the baseline

IGF-1 levels in blood samples from LNCaP-bearing mice that were

subjected to energy restriction.

....

Good News! GLA and EPA Inhibit uPA. Of interest is the fact that uPA

production is inhibited by gamma-linolenic acid (GLA) and

eicosapentenoic acid (EPA).37 GLA and EPA, which are essential fatty

acids, are among the important players in the prevention of disease

and in maintenance of health. This is discussed by Barry Sears,

Ph.D., in Omega Rx Zone.38 Sears beautifully presents the

interconnection between restriction of calories, along with dietary

adjustments of carbohydrate, protein, and fat intake, and the

production of a class of fatty acids called eicosanoids. An

understanding of these issues is fundamental to our ability to

prevent disease and maintain or recapture health.

More Advantages to Caloric Restriction and Avoidance of

Hyperinsulinemia. Sears stresses the importance of caloric

restriction by means of limiting the intake of high-density

carbohydrates such as bread, pasta, grains in most cereals, and

starches such as those found in potatoes. This reduction of caloric

intake by lowering high-density carbohydrate intake decreases the

stimulation of the pancreas to make insulin and limits all the

adverse side effects associated with increased insulin levels

(hyperinsulinemia).

Caloric restriction has been shown to be an important factor in

augmenting the immune system and improving longevity. Caloric

restriction reduces free radical production, which if otherwise

unchecked, damages DNA and oxidizes polyunsaturated fats. Caloric

restriction increases levels of superoxide dismutase (SOD),

glutathione, melatonin, DHEA, peroxidase, and catalase. The latter

substances are important defense mechanisms in our body that are

known to decrease with aging. Caloric restriction is instrumental in

lowering the production of cortisol. Cortisol is associated with

increased stress levels, and an imbalance in cortisol production

leads to immune deficiency and bone loss through resorption, leading

to osteopenia and osteoporosis, as well as muscle breakdown and aging

of the skin.

Calorie restriction, as proposed by Sears and others, has been shown

to also reduce advanced glycosylated end-products (AGE). These are

carbohydrate-protein complexes associated with hyperinsulinemic

states; they are associated with cardiovascular disease, Alzheimer's

disease, kidney disease, and other degenerative states.

We need to rethink how much food we need to eat. Our ideal body

weight should be taken seriously. If we were to do this alone, we

would eliminate most cases of diabetes, hypertension,

hypercholesterolemia, stroke, heart disease, and a significant amount

of cancer from our lives and those of our loved ones. We should

consume 500 calories a meal and 100 calories a snack. Modifications

of this are based on the level of activity, age, and body surface

area. Nutritional software and nutritional counseling should be an

integral part of our approach to good health.

....

Cheers, Al Pater

[Guest guest]

Talking to my doc, my conclusion was every adult male has a carcinoma cell and if you take enough biopsies, you'll find it. I think a lot of influence is from the fact if you tell a guy he's high PSA, his head gets torqued a lot. I mean a LOT. In fact, he can have BPH, but it still doesn't mean he doesn't have PCa too. There's no test with a specificity of 100%.

I vote to do the PSA and %PSA test and a biopsy once in while. No more invasive then a colonoscopy.

It's the cost they're worried about.

Regards.

"In this week's issue of The Journal of the American Medical Association, Coltman and colleagues reported the results of a study of some 8,600 men who underwent PSA testing. All the men in the study agreed to have a prostate biopsy -- whether or not they had a high PSA score.

"It was astonishing," Coltman says. "We found individuals with prostate cancer at every range of PSA --from 4 down to 0.1. And a substantial number of them had high-grade prostate cancer. In fact, some of these cancers were in men who had gone through seven years of PSA and digital rectal exams and were found to be normal in all respects."

----- Original Message -----

From: Rodney

Sent: Monday, July 11, 2005 8:35 PM

Subject: [ ] Prostate Cancer Information

Hi folks:It looks like there is some excellent basic information on prostate cancer, both in the main article and in the links it contains, here:http://www.foxnews.com/story/0,2933,162156,00.htmlRodney.

[Guest guest]

Hi Alan,

I don't understand your meaning. They already do annual digitals and they don't detect PCa in all men. Neither does both digital and PSA test. This article says they don't have a good set of tests fro PSAs from 0.1 up. If a guy has <4 PSA and a good digital, it's unlikely they will do a biopsy and find the PCa's and a good % of those were bad. PCA is # 2 cancer after lung for men.

IMO, not a small issue. OTOH, if you get a positive biopsy (the only way to define PCa), there is the issue of what to do about it - treat it or not. They likely won't treat it in an oldie, because he "will die anyway". I hate that philosophy. It means if you have it, they won't detect until too late. It's important if you plan to live to 99yo.

If you have PSA>4, enlarged prostate, AND a negative biopsy, I guarantee you'll feel a lot better than without the biopsy.

They want to rule out PSA tests as a routine test, because they're afraid of (or can't handle) the results. The whole issue is, if they don't detect it they don't have to treat it.

Regards.

----- Original Message -----

From: Al Pater

Sent: Wednesday, July 13, 2005 4:49 PM

Subject: Re: [ ] Prostate Cancer Information

Hi All,I vote to replace the biopsies with annual digital exams for prostate enlargement.--- jwwright <jwwright@...> wrote:> Talking to my doc, my conclusion was every adult male has a carcinoma cell and if> you take enough biopsies, you'll find it. I think a lot of influence is from the> fact if you tell a guy he's high PSA, his head gets torqued a lot. I mean a LOT.> In fact, he can have BPH, but it still doesn't mean he doesn't have PCa too.> There's no test with a specificity of 100%.> > I vote to do the PSA and %PSA test and a biopsy once in while. No more invasive> then a colonoscopy. > > It's the cost they're worried about.> > Regards.> > "In this week's issue of The Journal of the American Medical Association, Coltman> and colleagues reported the results of a study of some 8,600 men who underwent PSA> testing. All the men in the study agreed to have a prostate biopsy -- whether or> not they had a high PSA score.Al Pater, PhD; email: old542000@...