ALA (Was: Re: Soy and BPH)

[Guest guest]

Rodney, here's a recent (July 2004) study that validates your

concern about ALA.

However, I have not seen total religion yet. I still have the doubt

that concern about ALA should only apply to dudes with advanced PaC,

or BPH, or diabetes, or some other serious risk factor. If one has

the enzymes necessary to process ALA than why would it be a concern?

Definitely some dudes should avoid ALA " at all costs, " as you

suggest.

http://www.ajcn.org/cgi/content/abstract/80/1/204

Conclusions: Increased dietary intakes of ALA may increase the risk

of advanced prostate cancer. In contrast, EPA and DHA intakes may

reduce the risk of total and advanced prostate cancer.

Dietary intake of n–3 and n–6 fatty acids and the risk of

prostate

cancer1,2,3

F Leitzmann, Meir J Stampfer, Dominique S Michaud, Katarina

Augustsson, Graham C Colditz, Walter C Willett and L

Giovannucci

1 From the Nutritional Epidemiology Branch, Division of Cancer

Epidemiology and Genetics, National Cancer Institute, NIH, DHHS,

Bethesda, MD (MFL and DSM); the Departments of Epidemiology and

Nutrition, Harvard School of Public Health, Boston (MJS, WCW, and

ELG); the Channing Laboratory, Department of Medicine, Harvard

Medical School and Brigham and Women's Hospital, Boston (MJS,

GCC,

WCW, and ELG); and the Department of Medical Epidemiology,

Karolinska Institutet, Stockholm (KA)

Background: Laboratory studies have shown that n–3 fatty acids

inhibit and n–6 fatty acids stimulate prostate tumor growth, but

whether the dietary intake of these fatty acids affects prostate

cancer risk in humans remains unclear.

Objective: We prospectively evaluated the association between

intakes of -linolenic (ALA; 18:3n–3), eicosapentaenoic (EPA;

20:5n–

3), docosahexaenoic (DHA; 22:6n–3), linoleic (LA; 18:2n–6),

and

arachidonic (AA; 20:4n–6) acids and prostate cancer risk.

Design: A cohort of 47 866 US men aged 40–75 y with no cancer

history in 1986 was followed for 14 y.

Results: During follow-up, 2965 new cases of total prostate cancer

were ascertained, 448 of which were advanced prostate cancer. ALA

intake was unrelated to the risk of total prostate cancer. In

contrast, the multivariate relative risks (RRs) of advanced prostate

cancer from comparisons of extreme quintiles of ALA from nonanimal

sources and ALA from meat and dairy sources were 2.02 (95% CI: 1.35,

3.03) and 1.53 (0.88, 2.66), respectively. EPA and DHA intakes were

related to lower prostate cancer risk. The multivariate RRs of total

and advanced prostate cancer from comparisons of extreme quintiles

of the combination of EPA and DHA were 0.89 (0.77, 1.04) and 0.74

(0.49, 1.08), respectively. LA and AA intakes were unrelated to the

risk of prostate cancer. The multivariate RR of advanced prostate

cancer from a comparison of extreme quintiles of the ratio of LA to

ALA was 0.62 (0.45, 0.86).

Conclusions: Increased dietary intakes of ALA may increase the risk

of advanced prostate cancer. In contrast, EPA and DHA intakes may

reduce the risk of total and advanced prostate cancer.

Key Words: Diet • n–3 fatty acids • n–6 fatty acids

• prostate

cancer • cohort study

--- In , " Rodney " <perspect1111@y...>

wrote:

>

> Note especially the: " avoid canola and flaxseed oils at all

costs. "

> No doubt this is because of the ALA content....

--- In , " Rodney " <perspect1111@y...>

wrote:

>

> Note especially the: " avoid canola and flaxseed oils at all

costs. "

> No doubt this is because of the ALA content....