Plaque Deposition with Different Diets

September 10, 2004

Hi folks (Al especially):

This looks like a possibly very interesting study. Is there a way we

can get to see the full text? The precise nature of the diets

(especially what kind of fats were high in the 'high fat' diet) and

how plaque deposition varied with each might be very instructive:

" Dietary patterns and the odds of carotid atherosclerosis in women:

the Framingham Nutrition Studies.

Millen BE, Quatromoni PA, Nam BH, O'Horo CE, Polak JF, D'Agostino RB.

Department of Social and Behavioral Sciences, Boston University

School of Public Health, Room 263W, 715 Albany Street, Boston, MA

02118, USA. bmillen@...

BACKGROUND: We prospectively examined the relationship between

dietary patterns, assessed using cluster analysis and a food

frequency questionnaire, and the presence of carotid artery stenosis,

a subclinical marker of atherosclerotic disease. METHODS: Analyses

were conducted among 1,423 Framingham Study women without

cardiovascular disease (CVD) at baseline (1984-1988). Carotid

atherosclerosis (stenosis > or =25%) was measured by ultrasound 12

years later. RESULTS: Baseline differences in risk factor profiles

were notable across five dietary subgroups. Compared to the more

desirable profiles of women with Heart Healthy eating patterns, women

who had Light Eating, High Fat, or Empty Calorie diets had higher

rates of dyslipidemia and smoking and lower levels of physical

activity. At follow-up, the prevalence of carotid atherosclerosis

ranged from 6.8% in the Heart Health group to 17.8% in the Empty

Calorie group. Compared with Heart Health women, all other groups

displayed higher age-adjusted odds for carotid stenosis. In

multivariate analyses, those with Empty Calorie diets had more than

twofold increased odds of carotid atherosclerosis compared to Heart

Health women (OR 2.28, 95% CI [1.12, 4.62]; P < 0.05). CONCLUSION:

The association among unique dietary patterns, CVD risk factor

profiles, and the presence of subclinical atherosclerosis identifies

candidates and strategies for preventive behavioral interventions to

promote the primary prevention of heart disease.

PMID: 12460521 [PubMed - indexed for MEDLINE] "

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