Re: Uric Acid Strong Predictor of Death in Middle Aged Men

[Guest guest]

--- In , " Rodney " <perspect1111@y...>

wrote:

> Hi folks:

>

> http://www.heartcenteronline.com/myheartdr/home/research-detail.cfm?

> reutersid=4573 & nl=4

>

> http://snipurl.com/88nc

Hi All,

Its pdf-available:

In age-adjusted analyses, serum uric acid levels in the upper third

were associated with a greater than 2.5-fold higher risk of death

from cardiovascular disease than levels in the lower third. Taking

into account cardiovascular risk factors and variables commonly

associated with gout increased the relative risk to 3.73. Further

adjustment for factors related to the metabolic syndrome strengthened

the risk to 4.77. Excluding the 53 men using diuretics did not alter

the results. In age-adjusted analyses, men with serum uric acid

levels in the upper third were 1.7-fold more likely to die of any

cause than men with levels in the lower third. Adjustment for further

risk factors strengthened the association somewhat. CONCLUSIONS:

Serum uric acid levels are a strong predictor of cardiovascular

disease mortality in healthy middle-aged men, independent of

variables commonly associated with gout or the metabolic syndrome.

Serum uric acid measurement is an easily available and inexpensive

risk marker, but whether its relationship to cardiovascular events is

circumstantial or causal remains to be answered.

PMID: 15277287 [PubMed - in process]

Cheers, Al Pater.

[Guest guest]

Hi Al:

It would be interesting to know the average uric acid levels of the

upper, middle and lower thirds in their study sample.

Do you know if there is there a way we can find out?

Rodney.

--- In , " old542000 " <apater@m...>

wrote:

> Hi All,

>

> Its pdf-available:

>

> In age-adjusted analyses, serum uric acid levels in the upper third

> were associated with a greater than 2.5-fold higher risk of death

> from cardiovascular disease than levels in the lower third. Taking

> into account cardiovascular risk factors and variables commonly

> associated with gout increased the relative risk to 3.73. Further

> adjustment for factors related to the metabolic syndrome

strengthened

> the risk to 4.77. Excluding the 53 men using diuretics did not

alter

> the results. In age-adjusted analyses, men with serum uric acid

> levels in the upper third were 1.7-fold more likely to die of any

> cause than men with levels in the lower third. Adjustment for

further

> risk factors strengthened the association somewhat. CONCLUSIONS:

> Serum uric acid levels are a strong predictor of cardiovascular

> disease mortality in healthy middle-aged men, independent of

> variables commonly associated with gout or the metabolic syndrome.

> Serum uric acid measurement is an easily available and inexpensive

> risk marker, but whether its relationship to cardiovascular events

is

> circumstantial or causal remains to be answered.

>

> PMID: 15277287 [PubMed - in process]

>

> Cheers, Al Pater.

[Guest guest]

Probably the text of the paper would tell.

>From: " Rodney " <perspect1111@...>

>Reply-

>

>Subject: [ ] Re: " Uric Acid Strong Predictor of Death in

>Middle Aged Men "

>Date: Thu, 05 Aug 2004 01:59:26 -0000

>

>Hi Al:

>

>It would be interesting to know the average uric acid levels of the

>upper, middle and lower thirds in their study sample.

>

>Do you know if there is there a way we can find out?

>

>Rodney.

>

>--- In , " old542000 " <apater@m...>

>wrote:

>

> > Hi All,

> >

> > Its pdf-available:

> >

> > In age-adjusted analyses, serum uric acid levels in the upper third

> > were associated with a greater than 2.5-fold higher risk of death

> > from cardiovascular disease than levels in the lower third. Taking

> > into account cardiovascular risk factors and variables commonly

> > associated with gout increased the relative risk to 3.73. Further

> > adjustment for factors related to the metabolic syndrome

>strengthened

> > the risk to 4.77. Excluding the 53 men using diuretics did not

>alter

> > the results. In age-adjusted analyses, men with serum uric acid

> > levels in the upper third were 1.7-fold more likely to die of any

> > cause than men with levels in the lower third. Adjustment for

>further

> > risk factors strengthened the association somewhat. CONCLUSIONS:

> > Serum uric acid levels are a strong predictor of cardiovascular

> > disease mortality in healthy middle-aged men, independent of

> > variables commonly associated with gout or the metabolic syndrome.

> > Serum uric acid measurement is an easily available and inexpensive

> > risk marker, but whether its relationship to cardiovascular events

>is

> > circumstantial or causal remains to be answered.

> >

> > PMID: 15277287 [PubMed - in process]

> >

> > Cheers, Al Pater.

>

[Guest guest]

Hi All,

Yes, Rodney:

" Uric Acid Tertiles, 1 (3.03-5.04 mg/dL), 2 (5.05-5.88 mg/dL) and 3

(5.89-9.58 mg/dL).

Cheers, Al.

--- In , " Rodney " <perspect1111@y...>

wrote:

> Hi Al:

>

> It would be interesting to know the average uric acid levels of the

> upper, middle and lower thirds in their study sample.

>

> >

> > PMID: 15277287 [PubMed - in process]