Re: 0.2 % ALA converted to EPA

[Guest guest]

here's the full text:

http://circ.ahajournals.org/cgi/content/full/108/2/155

regards.

----- Original Message -----

From: jwwright

Sent: Tuesday, September 21, 2004 8:10 AM

Subject: Re: [ ] Re: No Correlation of ALA with BPH/PC

Yes.

The only thing for sure - it begins with inflammation. So either ALA or a metabolite could be the cause, but so could many other things. It's still an unknown.

One recognized CR guy is still touting flax instead of fish, but the cardios are high on fish. If it's an inflammation thing for both heart disease (atherosclerosis) and cancer, IMO, the use of fish or ALA is going to be consistent.

Also for sure, not a lot of these authors are saying much about intake levels of ALA or fish/EPA.

But I can't see eating ALA if I only convert 0.2% to EPA.

American Heart Association, Inc.

Volume 108(2) 15 July 2003 pp 155-160

Habitual Dietary Intake of n-3 and n-6 Fatty Acids in Relation to Inflammatory Markers Among US Men and Women

"EPA and DHA are much more effective than ALA in altering membrane composition and eicosanoid production, and it was recently estimated that in humans, only 0.2% of plasma ALA is converted to EPA. 35,36 The conversion rate of LA to arachidonic acid is also very low 37; however, because of the much higher intake, we speculate that LA still affects arachidonic acid concentrations, whereas ALA, because of its low intake and low conversion rate, has no substantial effect on EPA levels, and thus on inflammation, in the present study population."

35. Whelan J, Broughton KS, Kinsella JE. The comparative effects of dietary alpha-linolenic acid and fish oil on 4- and 5-series leukotriene formation in vivo. Lipids. 1991; 26: 119–126

36. Pawlosky RJ, Hibbeln JR, Novotny JA, et al. Physiological compartmental analysis of alpha-linolenic acid metabolism in adult humans. J Lipid Res. 2001; 42: 1257–1265.

37. Emken EA, Adlof RO, Gulley RM. Dietary linoleic acid influences desaturation and acylation of deuterium-labeled linoleic and linolenic acids in young adult males. Biochim Biophys Acta. 1994; 1213: 277–288.

Regards

[Guest guest]

Hi folks:

Interesting charts from JW's link. The columns in the far right

corners of both the three-dimensional charts are the shortest. This

apparently indicates that the lowest levels of inflammation occur

with the highest intakes of EPA+DHA ***AND*** LA - not just high

DHA+EPA. (I am not sure if the gif, or a link to it, will show up

below):

http://circ.ahajournals.org/content/vol108/issue2/images/medium/11FF2.

gif

http://snipurl.com/9835

Rodney

--- In , " jwwright " <jwwright@e...>

wrote:

> here's the full text:

> http://circ.ahajournals.org/cgi/content/full/108/2/155

> regards.

> ----- Original Message -----

> From: jwwright

>

> Sent: Tuesday, September 21, 2004 8:10 AM

> Subject: Re: [ ] Re: No Correlation of ALA with

BPH/PC

>

>

> Yes.

> The only thing for sure - it begins with inflammation. So

either ALA or a metabolite could be the cause, but so could many

other things. It's still an unknown.

> One recognized CR guy is still touting flax instead of fish, but

the cardios are high on fish. If it's an inflammation thing for both

heart disease (atherosclerosis) and cancer, IMO, the use of fish or

ALA is going to be consistent.

> Also for sure, not a lot of these authors are saying much about

intake levels of ALA or fish/EPA.

>

> But I can't see eating ALA if I only convert 0.2% to EPA.

> American Heart Association, Inc.

>

> Volume 108(2) 15 July 2003 pp 155-160

>

> Habitual Dietary Intake of n-3 and n-6 Fatty Acids in Relation to

Inflammatory Markers Among US Men and Women

>

> " EPA and DHA are much more effective than ALA in altering

membrane composition and eicosanoid production, and it was recently

estimated that in humans, only 0.2% of plasma ALA is converted to

EPA. 35,36 The conversion rate of LA to arachidonic acid is also very

low 37; however, because of the much higher intake, we speculate that

LA still affects arachidonic acid concentrations, whereas ALA,

because of its low intake and low conversion rate, has no substantial

effect on EPA levels, and thus on inflammation, in the present study

population. "

>

> 35. Whelan J, Broughton KS, Kinsella JE. The comparative effects

of dietary alpha-linolenic acid and fish oil on 4- and 5-series

leukotriene formation in vivo. Lipids. 1991; 26: 119-126

>

> 36. Pawlosky RJ, Hibbeln JR, Novotny JA, et al. Physiological

compartmental analysis of alpha-linolenic acid metabolism in adult

humans. J Lipid Res. 2001; 42: 1257-1265.

>

> 37. Emken EA, Adlof RO, Gulley RM. Dietary linoleic acid

influences desaturation and acylation of deuterium-labeled linoleic

and linolenic acids in young adult males. Biochim Biophys Acta. 1994;

1213: 277-288.

>

> Regards

[Guest guest]

Hi JW:

It looks to me like ~33:1 omega-6 to DHA+EPA. I.E. 6.19% of energy

compared with 0.19%. Or am I confused here?

Of course this does not include the ALA, so the ratio of omega-6 to

total omega-3 would be lower.

Rodney.

> > here's the full text:

> > http://circ.ahajournals.org/cgi/content/full/108/2/155

> > regards.

> > ----- Original Message -----

> > From: jwwright

> >

> > Sent: Tuesday, September 21, 2004 8:10 AM

> > Subject: Re: [ ] Re: No Correlation of ALA with

> BPH/PC

> >

> >