Anti-oxidants in MS

[Guest guest]

There are lots of papers suggesting that anti-oxidants are crucial.

Everyone should be taking those. Fish oils are a good source.

Yash

The role of oxidative stress in the pathogenesis of multiple

sclerosis: the need for effective antioxidant therapy.

Journal of Neurology. 251(3):261-8, 2004 Mar.

Abstract

Accumulating data indicate that oxidative stress (OS) plays a major

role in the pathogenesis of multiple sclerosis (MS). Reactive oxygen

species (ROS), leading to OS, generated in excess primarily by

macrophages, have been implicated as mediators of demyelination and

axonal damage in both MS and experimental autoimmune

encephalomyelitis (EAE), its animal model. ROS cause damage to

cardinal cellular components such as lipids, proteins and nucleic

acids (e. g., RNA, DNA), resulting in cell death by necrosis or

apoptosis. In addition, weakened cellular antioxidant defense

systems in the central nervous system (CNS) in MS, and its

vulnerability to ROS effects may increase damage. Thus, treatment

with antioxidants might theoretically prevent propagation of tissue

damage and improve both survival and neurological outcome. Indeed,

several experimental studies have been performed to see whether

dietary intake of several antioxidants prevents or reduces the

progression of EAE. Although a few antioxidants showed some efficacy

in these studies, little information is available on the effect of

treatments with such compounds in patients with MS. Well-designed

clinical studies using antioxidant intake, as well as investigations

based on larger cohorts studied over a longer periods of time, are

needed in order to assess whether antioxidant intake together with

other conventional treatments, might be beneficial in treating MS.

[Guest guest]

Probably one of the most effective antioxidants is the Alpha Lipoic

Acid (ALA). It works very well with LDN but any additional benefit

from ALA is supposed to come only after a long time.The recommended

daily intake is from 200 up to 600 mg/day. Unfortunately,

antioxidants are a bit expensive and this drug does make no exception.

> There are lots of papers suggesting that anti-oxidants are crucial.

> Everyone should be taking those. Fish oils are a good source.

> Yash

>

> The role of oxidative stress in the pathogenesis of multiple

> sclerosis: the need for effective antioxidant therapy.

>

> Journal of Neurology. 251(3):261-8, 2004 Mar.

>

> Abstract

> Accumulating data indicate that oxidative stress (OS) plays a major

> role in the pathogenesis of multiple sclerosis (MS). Reactive

oxygen

> species (ROS), leading to OS, generated in excess primarily by

> macrophages, have been implicated as mediators of demyelination and

> axonal damage in both MS and experimental autoimmune

> encephalomyelitis (EAE), its animal model. ROS cause damage to

> cardinal cellular components such as lipids, proteins and nucleic

> acids (e. g., RNA, DNA), resulting in cell death by necrosis or

> apoptosis. In addition, weakened cellular antioxidant defense

> systems in the central nervous system (CNS) in MS, and its

> vulnerability to ROS effects may increase damage. Thus, treatment

> with antioxidants might theoretically prevent propagation of tissue

> damage and improve both survival and neurological outcome. Indeed,

> several experimental studies have been performed to see whether

> dietary intake of several antioxidants prevents or reduces the

> progression of EAE. Although a few antioxidants showed some

efficacy

> in these studies, little information is available on the effect of

> treatments with such compounds in patients with MS. Well-designed

> clinical studies using antioxidant intake, as well as

investigations

> based on larger cohorts studied over a longer periods of time, are

> needed in order to assess whether antioxidant intake together with

> other conventional treatments, might be beneficial in treating MS.